Efek Loading Statin Intensitas Tinggi Sebelum Intervensi Koroner Perkutan pada Pasien Sindrom Koroner Akut: Systematic Review
<div class="WordSection1"><p><span data-preserver-spaces="true">Percutaneous Coronary Intervention (PCI) is one of the essential methods for Acute Coronary Syndrome (ACS) treatment, but this procedure has serious complications. Early loading dose statin has a fa...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine at Universitas Andalas
2024-09-01
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| Series: | Jurnal Kesehatan Andalas |
| Online Access: | http://jurnal.fk.unand.ac.id/index.php/jka/article/view/2244 |
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| Summary: | <div class="WordSection1"><p><span data-preserver-spaces="true">Percutaneous Coronary Intervention (PCI) is one of the essential methods for Acute Coronary Syndrome (ACS) treatment, but this procedure has serious complications. Early loading dose statin has a favorable prognostic impact on patients undergoing PCI. </span><span data-preserver-spaces="true">However, this effect </span><span data-preserver-spaces="true">is</span><span data-preserver-spaces="true"> still </span><span data-preserver-spaces="true">unclear</span><span data-preserver-spaces="true">.</span><strong>Objective</strong><span data-preserver-spaces="true">: To </span><span data-preserver-spaces="true">evaluated</span><span data-preserver-spaces="true"> the effect of loading high-intensity statin on Major Adverse Cardiac Events (MACE) before PCI in patients with ACS. </span><strong>Methods</strong><span data-preserver-spaces="true">: Randomized controlled trials </span><span data-preserver-spaces="true">were conducted</span><span data-preserver-spaces="true"> using databases from CENTRAL, PubMed, Science Direct, and British Medical Journal. Then, titles, abstracts, and full texts </span><span data-preserver-spaces="true">were screened</span><span data-preserver-spaces="true"> using the inclusion criteria to filter out irrelevant studies. Quality assessments </span><span data-preserver-spaces="true">were undertaken</span><span data-preserver-spaces="true"> using the Jadad scale, and the results were narratively synthesized and presented in tables. </span><strong>Results</strong><span data-preserver-spaces="true">: Seven studies </span><span data-preserver-spaces="true">were included</span><span data-preserver-spaces="true"> in this systematic review after screening 1037 records. Four studies demonstrated a statistically significant reduction in MACE in the groups that received loading dose atorvastatin or rosuvastatin before PCI, compared with the comparator groups (p < 0.05). </span><strong>Conclusion</strong>: Loading high-intensity statin before PCI seems to be highly effective in reducing MACE in patients with ACS.</p><p><strong>Keywords</strong>: acute coronary syndrome, major adverse cardiac events, percutaneous coronary intervention</p><p> </p></div> |
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| ISSN: | 2301-7406 2615-1138 |