Combination therapy with alisertib enhances the anti-tumor immunity induced by a liver cancer vaccine

Combination therapy with alisertib enhances the anti-tumor immunity induced by a liver cancer vaccine

Summary: Alisertib is a potent aurora A kinase inhibitor in clinical trials for cancer treatment, but its efficacy on cancer vaccines remains unclear. Here, we developed a DNA vaccine targeting glypican-3 (pGPC3) and evaluated its efficacy with alisertib in hepatocellular carcinoma (HCC) models. The...

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Bibliographic Details
Main Authors: Fang Xue, Jing Liu, Jinyan Wu, Xueer Li, Ningning Zhu, Shuting Tang, Mengli Zhang, Huan Duan, Rui Wang, Jing Zhang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Immunology
Systems biology
Cancer systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225003803
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