Rare case of Infiltrative multifocal Ewing sarcoma presenting as neck mass
Ewing sarcoma is a rare, highly aggressive small round cell tumor that primarily affects the bones of adolescents and young adults, with extra skeletal involvement being particularly uncommon. We present the case of an 18-year-old male with a progressively enlarging, painful swelling in the right po...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-10-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325006430 |
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| author | Shubhlaxmi Srivastava, MBBS Gaurav Raj, MD Kaustubh Gupta, MD Ajeet Kumar Gandhi, MD Nilesh Kumar Sinha, MBBS |
| author_facet | Shubhlaxmi Srivastava, MBBS Gaurav Raj, MD Kaustubh Gupta, MD Ajeet Kumar Gandhi, MD Nilesh Kumar Sinha, MBBS |
| author_sort | Shubhlaxmi Srivastava, MBBS |
| collection | DOAJ |
| description | Ewing sarcoma is a rare, highly aggressive small round cell tumor that primarily affects the bones of adolescents and young adults, with extra skeletal involvement being particularly uncommon. We present the case of an 18-year-old male with a progressively enlarging, painful swelling in the right posterior neck, ultimately diagnosed as Extra skeletal Ewing sarcoma involving the occipital bone and C1 vertebra. Imaging revealed extensive intracranial, intraspinal, and paravertebral extension with multiple skeletal metastases. Histopathological and immunohistochemical analysis confirmed the diagnosis, showing NKX 2.2 positivity. The patient was initiated on systemic chemotherapy using the VDC/IE regimen, leading to significant clinical and radiological improvement. This case underscores the importance of considering Ewing sarcoma in atypical paraspinal and cranial presentations and highlights the critical role of early multimodal imaging and chemotherapy in managing aggressive disease. |
| format | Article |
| id | doaj-art-527cb58015514a798ff9bc16f61ebcc0 |
| institution | Kabale University |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-527cb58015514a798ff9bc16f61ebcc02025-08-20T03:58:00ZengElsevierRadiology Case Reports1930-04332025-10-0120105296529910.1016/j.radcr.2025.06.101Rare case of Infiltrative multifocal Ewing sarcoma presenting as neck massShubhlaxmi Srivastava, MBBS0Gaurav Raj, MD1Kaustubh Gupta, MD2Ajeet Kumar Gandhi, MD3Nilesh Kumar Sinha, MBBS4Corresponding author.; Department of Radio-Diagnosis, Dr Ram Manohar Lohia Institute Of Medical Sciences, Lucknow, Uttar Pradesh, IndiaDepartment of Radio-Diagnosis, Dr Ram Manohar Lohia Institute Of Medical Sciences, Lucknow, Uttar Pradesh, IndiaDepartment of Radio-Diagnosis, Dr Ram Manohar Lohia Institute Of Medical Sciences, Lucknow, Uttar Pradesh, IndiaDepartment of Radio-Diagnosis, Dr Ram Manohar Lohia Institute Of Medical Sciences, Lucknow, Uttar Pradesh, IndiaDepartment of Radio-Diagnosis, Dr Ram Manohar Lohia Institute Of Medical Sciences, Lucknow, Uttar Pradesh, IndiaEwing sarcoma is a rare, highly aggressive small round cell tumor that primarily affects the bones of adolescents and young adults, with extra skeletal involvement being particularly uncommon. We present the case of an 18-year-old male with a progressively enlarging, painful swelling in the right posterior neck, ultimately diagnosed as Extra skeletal Ewing sarcoma involving the occipital bone and C1 vertebra. Imaging revealed extensive intracranial, intraspinal, and paravertebral extension with multiple skeletal metastases. Histopathological and immunohistochemical analysis confirmed the diagnosis, showing NKX 2.2 positivity. The patient was initiated on systemic chemotherapy using the VDC/IE regimen, leading to significant clinical and radiological improvement. This case underscores the importance of considering Ewing sarcoma in atypical paraspinal and cranial presentations and highlights the critical role of early multimodal imaging and chemotherapy in managing aggressive disease.http://www.sciencedirect.com/science/article/pii/S1930043325006430ChemotherapyEwing sarcomaNKX 2.2Small round cell tumorSkeletal metastasisVDC/IE regimen |
| spellingShingle | Shubhlaxmi Srivastava, MBBS Gaurav Raj, MD Kaustubh Gupta, MD Ajeet Kumar Gandhi, MD Nilesh Kumar Sinha, MBBS Rare case of Infiltrative multifocal Ewing sarcoma presenting as neck mass Radiology Case Reports Chemotherapy Ewing sarcoma NKX 2.2 Small round cell tumor Skeletal metastasis VDC/IE regimen |
| title | Rare case of Infiltrative multifocal Ewing sarcoma presenting as neck mass |
| title_full | Rare case of Infiltrative multifocal Ewing sarcoma presenting as neck mass |
| title_fullStr | Rare case of Infiltrative multifocal Ewing sarcoma presenting as neck mass |
| title_full_unstemmed | Rare case of Infiltrative multifocal Ewing sarcoma presenting as neck mass |
| title_short | Rare case of Infiltrative multifocal Ewing sarcoma presenting as neck mass |
| title_sort | rare case of infiltrative multifocal ewing sarcoma presenting as neck mass |
| topic | Chemotherapy Ewing sarcoma NKX 2.2 Small round cell tumor Skeletal metastasis VDC/IE regimen |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325006430 |
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