Association between CD36 and ischemic stroke: consequential or coincidental?
CD36 is a transmembrane protein that plays a role in various biological processes, including oxidized low-density lipoprotein and fatty acid uptake as well as regulatory control for inflammation signaling. Its robust expression in monocytes and macrophages associated with its ability to translocate...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2025-05-01
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| Series: | Exploration of Neuroscience |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100688/100688.pdf |
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| author | Ana-Maria Dobri-Nicoară Ionela Daniela Popescu Elena Codrici Maria Dudău Ana-Maria Enciu Cristiana Tanase |
| author_facet | Ana-Maria Dobri-Nicoară Ionela Daniela Popescu Elena Codrici Maria Dudău Ana-Maria Enciu Cristiana Tanase |
| author_sort | Ana-Maria Dobri-Nicoară |
| collection | DOAJ |
| description | CD36 is a transmembrane protein that plays a role in various biological processes, including oxidized low-density lipoprotein and fatty acid uptake as well as regulatory control for inflammation signaling. Its robust expression in monocytes and macrophages associated with its ability to translocate fatty acids linked this scavenger receptor to foam cell formation and atherosclerosis. In the context of ischemic stroke, CD36 has been shown to contribute to brain injury and inflammation. Preclinical studies have demonstrated that CD36 expression increases in the brain after stroke and that inhibiting CD36 can reduce infarction size and improve neurological outcomes in animal models. These findings suggest that CD36 may be a potential therapeutic target for ischemic stroke. However, no clinical trials addressing CD36 and acute ischemic stroke are registered in the American or European databases. This review will discuss the relationship between CD36 and ischemic stroke and present some clinical findings in patients with single nucleotide polymorphisms of the CD36 gene. |
| format | Article |
| id | doaj-art-52718b76f79f4264bcc52409f25be37a |
| institution | OA Journals |
| issn | 2834-5347 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Neuroscience |
| spelling | doaj-art-52718b76f79f4264bcc52409f25be37a2025-08-20T02:31:43ZengOpen Exploration Publishing Inc.Exploration of Neuroscience2834-53472025-05-01410068810.37349/en.2025.100688Association between CD36 and ischemic stroke: consequential or coincidental?Ana-Maria Dobri-Nicoară0https://orcid.org/0000-0003-3584-9808Ionela Daniela Popescu1https://orcid.org/0000-0001-8751-0043Elena Codrici2https://orcid.org/0000-0002-5507-1020Maria Dudău3https://orcid.org/0000-0002-5071-9756Ana-Maria Enciu4https://orcid.org/0000-0002-8122-1096Cristiana Tanase5https://orcid.org/0000-0002-2122-0235Carol Davila University of Medicine and Pharmacy, 050047 Bucharest, RomaniaVictor Babes National Institute of Pathology, 050096 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050047 Bucharest, Romania; Victor Babes National Institute of Pathology, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 050096 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050047 Bucharest, Romania; Victor Babes National Institute of Pathology, 050096 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050047 Bucharest, Romania; Cajal Institute, Titu Maiorescu University, 040051 Bucharest, RomaniaCD36 is a transmembrane protein that plays a role in various biological processes, including oxidized low-density lipoprotein and fatty acid uptake as well as regulatory control for inflammation signaling. Its robust expression in monocytes and macrophages associated with its ability to translocate fatty acids linked this scavenger receptor to foam cell formation and atherosclerosis. In the context of ischemic stroke, CD36 has been shown to contribute to brain injury and inflammation. Preclinical studies have demonstrated that CD36 expression increases in the brain after stroke and that inhibiting CD36 can reduce infarction size and improve neurological outcomes in animal models. These findings suggest that CD36 may be a potential therapeutic target for ischemic stroke. However, no clinical trials addressing CD36 and acute ischemic stroke are registered in the American or European databases. This review will discuss the relationship between CD36 and ischemic stroke and present some clinical findings in patients with single nucleotide polymorphisms of the CD36 gene.https://www.explorationpub.com/uploads/Article/A100688/100688.pdfcd36acute ischemic strokeinflammationcd36–/– mouse model |
| spellingShingle | Ana-Maria Dobri-Nicoară Ionela Daniela Popescu Elena Codrici Maria Dudău Ana-Maria Enciu Cristiana Tanase Association between CD36 and ischemic stroke: consequential or coincidental? Exploration of Neuroscience cd36 acute ischemic stroke inflammation cd36–/– mouse model |
| title | Association between CD36 and ischemic stroke: consequential or coincidental? |
| title_full | Association between CD36 and ischemic stroke: consequential or coincidental? |
| title_fullStr | Association between CD36 and ischemic stroke: consequential or coincidental? |
| title_full_unstemmed | Association between CD36 and ischemic stroke: consequential or coincidental? |
| title_short | Association between CD36 and ischemic stroke: consequential or coincidental? |
| title_sort | association between cd36 and ischemic stroke consequential or coincidental |
| topic | cd36 acute ischemic stroke inflammation cd36–/– mouse model |
| url | https://www.explorationpub.com/uploads/Article/A100688/100688.pdf |
| work_keys_str_mv | AT anamariadobrinicoara associationbetweencd36andischemicstrokeconsequentialorcoincidental AT ioneladanielapopescu associationbetweencd36andischemicstrokeconsequentialorcoincidental AT elenacodrici associationbetweencd36andischemicstrokeconsequentialorcoincidental AT mariadudau associationbetweencd36andischemicstrokeconsequentialorcoincidental AT anamariaenciu associationbetweencd36andischemicstrokeconsequentialorcoincidental AT cristianatanase associationbetweencd36andischemicstrokeconsequentialorcoincidental |