Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma
Objective. In our previous study, we found that some miRNAs were deregulated in hepatocellular carcinoma (HCC), including miR-183. However, the expression of miR-183 in the progression of benign liver diseases to HCC and its correlation with clinicopathologic factors remain undefined. Methods. MiR-1...
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| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/381874 |
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| author | Zenghui Liang Yingtang Gao Wenxia Shi Daokuan Zhai Shilei Li Li Jing Hua Guo Tong Liu Yajie Wang Zhi Du |
| author_facet | Zenghui Liang Yingtang Gao Wenxia Shi Daokuan Zhai Shilei Li Li Jing Hua Guo Tong Liu Yajie Wang Zhi Du |
| author_sort | Zenghui Liang |
| collection | DOAJ |
| description | Objective. In our previous study, we found that some miRNAs were deregulated in hepatocellular carcinoma (HCC), including miR-183. However, the expression of miR-183 in the progression of benign liver diseases to HCC and its correlation with clinicopathologic factors remain undefined. Methods. MiR-183 expression was measured in normal controls (NC) (n=21), chronic viral hepatitis B or C (CH) tissues (n=10), liver cirrhosis (LC) tissues (n=18), HCC tissues (n=92), and adjacent nontumor tissues (NT) (n=92) by quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR). Results. The expression levels of miR-183 were significantly higher in HCC than in NT, LC, CH, and NL (P=0.001, P<0.001, P=0.011, P<0.001, resp.). The upregulated miR-183 in HCC was correlated with TNM stage (P=0.042) and cirrhosis (P=0.025). The Kaplan-Meier survival analysis showed that miR-183 expression was not associated with the survival of HCC patients. However, miR-183 yielded an area under the curve (AUC) of 0.808 with 59.8% sensitivity and 91.8% specificity in discriminating HCC from benign liver diseases (CH and LC) or NC. Conclusions. The upregulated miR-183 may associate with onset and progression of HCC, but not with the patient survival. A further research is needed to determine the potential of miR-183 as biomarker for HCC. |
| format | Article |
| id | doaj-art-526c958e69da41a4bf79f51bcc297fcf |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-526c958e69da41a4bf79f51bcc297fcf2025-08-20T02:05:42ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/381874381874Expression and Significance of MicroRNA-183 in Hepatocellular CarcinomaZenghui Liang0Yingtang Gao1Wenxia Shi2Daokuan Zhai3Shilei Li4Li Jing5Hua Guo6Tong Liu7Yajie Wang8Zhi Du9Third Central Clinical College of Tianjin Medical University, Tianjin 300170, ChinaKey Laboratory of Artificial Cell, Institute for Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin 300170, ChinaKey Laboratory of Artificial Cell, Institute for Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin 300170, ChinaKey Laboratory of Artificial Cell, Institute for Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin 300170, ChinaThird Central Clinical College of Tianjin Medical University, Tianjin 300170, ChinaKey Laboratory of Artificial Cell, Institute for Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin 300170, ChinaKey Laboratory of Artificial Cell, Institute for Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin 300170, ChinaKey Laboratory of Artificial Cell, Institute for Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin 300170, ChinaThird Central Clinical College of Tianjin Medical University, Tianjin 300170, ChinaThird Central Clinical College of Tianjin Medical University, Tianjin 300170, ChinaObjective. In our previous study, we found that some miRNAs were deregulated in hepatocellular carcinoma (HCC), including miR-183. However, the expression of miR-183 in the progression of benign liver diseases to HCC and its correlation with clinicopathologic factors remain undefined. Methods. MiR-183 expression was measured in normal controls (NC) (n=21), chronic viral hepatitis B or C (CH) tissues (n=10), liver cirrhosis (LC) tissues (n=18), HCC tissues (n=92), and adjacent nontumor tissues (NT) (n=92) by quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR). Results. The expression levels of miR-183 were significantly higher in HCC than in NT, LC, CH, and NL (P=0.001, P<0.001, P=0.011, P<0.001, resp.). The upregulated miR-183 in HCC was correlated with TNM stage (P=0.042) and cirrhosis (P=0.025). The Kaplan-Meier survival analysis showed that miR-183 expression was not associated with the survival of HCC patients. However, miR-183 yielded an area under the curve (AUC) of 0.808 with 59.8% sensitivity and 91.8% specificity in discriminating HCC from benign liver diseases (CH and LC) or NC. Conclusions. The upregulated miR-183 may associate with onset and progression of HCC, but not with the patient survival. A further research is needed to determine the potential of miR-183 as biomarker for HCC.http://dx.doi.org/10.1155/2013/381874 |
| spellingShingle | Zenghui Liang Yingtang Gao Wenxia Shi Daokuan Zhai Shilei Li Li Jing Hua Guo Tong Liu Yajie Wang Zhi Du Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma The Scientific World Journal |
| title | Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma |
| title_full | Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma |
| title_fullStr | Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma |
| title_full_unstemmed | Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma |
| title_short | Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma |
| title_sort | expression and significance of microrna 183 in hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2013/381874 |
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