Deteriorated biomechanical properties of human hypertrophied septum in response to cardiomyocyte enlargement, overexpressed collagen, and disarrayed microstructures

Deteriorated biomechanical properties of human hypertrophied septum in response to cardiomyocyte enlargement, overexpressed collagen, and disarrayed microstructures

Hypertrophic cardiomyopathy (HCM) is often caused by genetic mutations, resulting in abnormal thickening of ventricular muscle, particularly the septum, and causing left ventricular outflow tract (LVOT) obstruction and inferior cardiac performance. The cell and microstructural abnormalities are beli...

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Bibliographic Details
Main Authors: Katherine M. Copeland, Houjia Chen, Uday Chintapula, Milad Almasian, Duc Khang Chung, Alan M. Taylor, Yichen Ding, Gaurav Sharma, Michael E. Jessen, Yi Hong, Kytai T. Nguyen, Matthias Peltz, Pietro Bajona, Jun Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
emerging tools
concepts
and applications in multi-scale mechanobiology
hypertrophic cardiomyopathy
human hypertrophied septum
biomechanical deterioration
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1620594/full
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