Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide study
We aimed to evaluate whether the association between long-term temperature variability (TV) and cardio-cerebrovascular diseases (CCVDs) was affected by famine exposure in different age stages. We used data from the fourth national urban and rural elderly population survey (2015). Participants were c...
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IOP Publishing
2025-01-01
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| Series: | Environmental Research: Health |
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| Online Access: | https://doi.org/10.1088/2752-5309/ad6028 |
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| author | Yao Wu BinBin Su Junqing Xie Bo Wen Xiaolan Wu Mengfan Wang Yanhui Dong Yi Song Jun Ma |
| author_facet | Yao Wu BinBin Su Junqing Xie Bo Wen Xiaolan Wu Mengfan Wang Yanhui Dong Yi Song Jun Ma |
| author_sort | Yao Wu |
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| description | We aimed to evaluate whether the association between long-term temperature variability (TV) and cardio-cerebrovascular diseases (CCVDs) was affected by famine exposure in different age stages. We used data from the fourth national urban and rural elderly population survey (2015). Participants were categorized into six groups based on their age at famine exposure (famine exposure under age 5, between ages 5 and 18, and during adulthood) and the severity (severely affected areas versus mildly affected areas) of the Great Chinese Famine (1959–1961) in their province of residence. Mixed-effects logistic regression model was used to quantify the association between long-term TV and the prevalence of CCVDs across six famine-exposed groups. A total of 222 179 participants were included. In severely affected areas, the odds ratio (OR) of CCVDs associated with per 1 °C increase in 5 year average TV were 1.07 (95% confidence interval [CI]: 1.02, 1.13) for those exposed to famine during adulthood, 1.28 (95% CI: 1.17, 1.40) under the age of 5 years. Urban residence, higher education, increased household income, and more frequent physical activity could mitigate the association between TV and CCVDs, particularly among those exposed to severe famine before the age of 5. Individuals exposed to famine before the age of 5 are more susceptible to TV-related CCVDs compared to those exposed during adulthood. Our findings highlight the importance of early-life nutrition in lowering susceptibility to CCVDs later in life. |
| format | Article |
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| institution | Kabale University |
| issn | 2752-5309 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
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| series | Environmental Research: Health |
| spelling | doaj-art-52626fcd5311467b817da96559d1885a2025-01-27T10:39:55ZengIOP PublishingEnvironmental Research: Health2752-53092025-01-013101501310.1088/2752-5309/ad6028Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide studyYao Wu0https://orcid.org/0000-0002-8105-0522BinBin Su1Junqing Xie2Bo Wen3https://orcid.org/0000-0001-8379-1730Xiaolan Wu4Mengfan Wang5Yanhui Dong6Yi Song7Jun Ma8School of Public Health, Peking University Health Science Center , No 38 Xue Yuan Road, Haidian District, Beijing 100191, People’s Republic of China; Climate, Air Quality Research (CARE) Unit, School of Public Health and Preventive Medicine, Monash University , 553 St Kilda Road, Melbourne 3004, AustraliaSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences/Peking Union Medical College , No.31, Beijing, Dongcheng District, Beijing 100730, People’s Republic of ChinaCentre for Statistics in Medicine and NIHR Biomedical Research Centre Oxford, NDORMS, University of Oxford , Oxford, United KingdomClimate, Air Quality Research (CARE) Unit, School of Public Health and Preventive Medicine, Monash University , 553 St Kilda Road, Melbourne 3004, Australia; Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center , No 38 Xue Yuan Road, Haidian District, Beijing 100191, People’s Republic of ChinaChina Research Center on Ageing , No 48 Guang’ anmen South Street, Xicheng District, Beijing 100054, People’s Republic of ChinaUniversity of Toronto , st.Geogre, 27 King’s College Cir, Toronto ON M5S, CanadaInstitute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center , No 38 Xue Yuan Road, Haidian District, Beijing 100191, People’s Republic of ChinaInstitute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center , No 38 Xue Yuan Road, Haidian District, Beijing 100191, People’s Republic of ChinaInstitute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center , No 38 Xue Yuan Road, Haidian District, Beijing 100191, People’s Republic of ChinaWe aimed to evaluate whether the association between long-term temperature variability (TV) and cardio-cerebrovascular diseases (CCVDs) was affected by famine exposure in different age stages. We used data from the fourth national urban and rural elderly population survey (2015). Participants were categorized into six groups based on their age at famine exposure (famine exposure under age 5, between ages 5 and 18, and during adulthood) and the severity (severely affected areas versus mildly affected areas) of the Great Chinese Famine (1959–1961) in their province of residence. Mixed-effects logistic regression model was used to quantify the association between long-term TV and the prevalence of CCVDs across six famine-exposed groups. A total of 222 179 participants were included. In severely affected areas, the odds ratio (OR) of CCVDs associated with per 1 °C increase in 5 year average TV were 1.07 (95% confidence interval [CI]: 1.02, 1.13) for those exposed to famine during adulthood, 1.28 (95% CI: 1.17, 1.40) under the age of 5 years. Urban residence, higher education, increased household income, and more frequent physical activity could mitigate the association between TV and CCVDs, particularly among those exposed to severe famine before the age of 5. Individuals exposed to famine before the age of 5 are more susceptible to TV-related CCVDs compared to those exposed during adulthood. Our findings highlight the importance of early-life nutrition in lowering susceptibility to CCVDs later in life.https://doi.org/10.1088/2752-5309/ad6028faminetemperature variabilitycardio-cerebrovascular disease |
| spellingShingle | Yao Wu BinBin Su Junqing Xie Bo Wen Xiaolan Wu Mengfan Wang Yanhui Dong Yi Song Jun Ma Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide study Environmental Research: Health famine temperature variability cardio-cerebrovascular disease |
| title | Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide study |
| title_full | Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide study |
| title_fullStr | Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide study |
| title_full_unstemmed | Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide study |
| title_short | Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide study |
| title_sort | early life famine exposure may modify the association between long term temperature variability and cardio cerebrovascular diseases a nationwide study |
| topic | famine temperature variability cardio-cerebrovascular disease |
| url | https://doi.org/10.1088/2752-5309/ad6028 |
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