Insect-specific virus platforms for arbovirus vaccine development
Certain insect-specific viruses (ISVs), specifically the mosquito alphaviruses, Eilat and Yada Yada viruses, and orthoflaviviruses, Binjari, Aripo, YN15-283-02 and Chaoyang viruses, have emerged as potential platforms for generation of whole virus vaccines for human and veterinary applications. Thes...
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| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521104/full |
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| author | Roy A. Hall Roy A. Hall Wilson Nguyen Alexander A. Khromykh Alexander A. Khromykh Andreas Suhrbier Andreas Suhrbier |
| author_facet | Roy A. Hall Roy A. Hall Wilson Nguyen Alexander A. Khromykh Alexander A. Khromykh Andreas Suhrbier Andreas Suhrbier |
| author_sort | Roy A. Hall |
| collection | DOAJ |
| description | Certain insect-specific viruses (ISVs), specifically the mosquito alphaviruses, Eilat and Yada Yada viruses, and orthoflaviviruses, Binjari, Aripo, YN15-283-02 and Chaoyang viruses, have emerged as potential platforms for generation of whole virus vaccines for human and veterinary applications. These ISVs are remarkably tolerant of the substitution of their structural polyproteins with those of alphaviruses and orthoflaviviruses that are pathogenic in humans and/or animals. The resulting ISV-based chimeric vaccines have been evaluated in mouse models and have demonstrated safety and efficacy in non-human primates, crocodiles and pigs. Targets include chikungunya, Venezuelan and eastern equine encephalitis, dengue, Zika, yellow fever, Japanese encephalitis and West Nile viruses. ISV-based chimeric vaccines provide authentically folded tertiary and quaternary whole virion particle structures to the immune system, a key feature for induction of protective antibody responses. These vaccines are manufactured in C6/36 or C7-10 mosquito cell lines, where they grow to high titers, but they do not replicate in vertebrate vaccine recipients. This review discusses the progress of these emerging technologies and addresses challenges related to adjuvanting, safety, and manufacturing. |
| format | Article |
| id | doaj-art-525728b6b8414b95a942f4dc599c7ea7 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-525728b6b8414b95a942f4dc599c7ea72025-08-20T02:52:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15211041521104Insect-specific virus platforms for arbovirus vaccine developmentRoy A. Hall0Roy A. Hall1Wilson Nguyen2Alexander A. Khromykh3Alexander A. Khromykh4Andreas Suhrbier5Andreas Suhrbier6School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD, AustraliaGlobal Virus Network Centre of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD, AustraliaInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaSchool of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD, AustraliaGlobal Virus Network Centre of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD, AustraliaGlobal Virus Network Centre of Excellence, Australian Infectious Diseases Research Centre, Brisbane, QLD, AustraliaInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaCertain insect-specific viruses (ISVs), specifically the mosquito alphaviruses, Eilat and Yada Yada viruses, and orthoflaviviruses, Binjari, Aripo, YN15-283-02 and Chaoyang viruses, have emerged as potential platforms for generation of whole virus vaccines for human and veterinary applications. These ISVs are remarkably tolerant of the substitution of their structural polyproteins with those of alphaviruses and orthoflaviviruses that are pathogenic in humans and/or animals. The resulting ISV-based chimeric vaccines have been evaluated in mouse models and have demonstrated safety and efficacy in non-human primates, crocodiles and pigs. Targets include chikungunya, Venezuelan and eastern equine encephalitis, dengue, Zika, yellow fever, Japanese encephalitis and West Nile viruses. ISV-based chimeric vaccines provide authentically folded tertiary and quaternary whole virion particle structures to the immune system, a key feature for induction of protective antibody responses. These vaccines are manufactured in C6/36 or C7-10 mosquito cell lines, where they grow to high titers, but they do not replicate in vertebrate vaccine recipients. This review discusses the progress of these emerging technologies and addresses challenges related to adjuvanting, safety, and manufacturing.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521104/fullvaccinearbovirusEilat virusBinjari virusYada Yada virusAripo virus |
| spellingShingle | Roy A. Hall Roy A. Hall Wilson Nguyen Alexander A. Khromykh Alexander A. Khromykh Andreas Suhrbier Andreas Suhrbier Insect-specific virus platforms for arbovirus vaccine development Frontiers in Immunology vaccine arbovirus Eilat virus Binjari virus Yada Yada virus Aripo virus |
| title | Insect-specific virus platforms for arbovirus vaccine development |
| title_full | Insect-specific virus platforms for arbovirus vaccine development |
| title_fullStr | Insect-specific virus platforms for arbovirus vaccine development |
| title_full_unstemmed | Insect-specific virus platforms for arbovirus vaccine development |
| title_short | Insect-specific virus platforms for arbovirus vaccine development |
| title_sort | insect specific virus platforms for arbovirus vaccine development |
| topic | vaccine arbovirus Eilat virus Binjari virus Yada Yada virus Aripo virus |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521104/full |
| work_keys_str_mv | AT royahall insectspecificvirusplatformsforarbovirusvaccinedevelopment AT royahall insectspecificvirusplatformsforarbovirusvaccinedevelopment AT wilsonnguyen insectspecificvirusplatformsforarbovirusvaccinedevelopment AT alexanderakhromykh insectspecificvirusplatformsforarbovirusvaccinedevelopment AT alexanderakhromykh insectspecificvirusplatformsforarbovirusvaccinedevelopment AT andreassuhrbier insectspecificvirusplatformsforarbovirusvaccinedevelopment AT andreassuhrbier insectspecificvirusplatformsforarbovirusvaccinedevelopment |