HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation

Background. The introduction of direct-acting antivirals (DAA) for HCV has led to high rates of HCV eradication. Treatment of patients awaiting liver transplantation (LT) has been controversial. Recent data suggests that DAA treatment may accelerate recurrent HCC. The impact of DAA on delisting for...

Full description

Saved in:
Bibliographic Details
Main Authors: Juliet A. Emamaullee, Mariusz Bral, Glenda Meeberg, Aldo J. Montano-Loza, Vincent G. Bain, Kelly Warren Burak, David Bigam, A. M. James Shapiro, Norman Kneteman
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Canadian Journal of Gastroenterology and Hepatology
Online Access:http://dx.doi.org/10.1155/2019/2509059
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832545431905632256
author Juliet A. Emamaullee
Mariusz Bral
Glenda Meeberg
Aldo J. Montano-Loza
Vincent G. Bain
Kelly Warren Burak
David Bigam
A. M. James Shapiro
Norman Kneteman
author_facet Juliet A. Emamaullee
Mariusz Bral
Glenda Meeberg
Aldo J. Montano-Loza
Vincent G. Bain
Kelly Warren Burak
David Bigam
A. M. James Shapiro
Norman Kneteman
author_sort Juliet A. Emamaullee
collection DOAJ
description Background. The introduction of direct-acting antivirals (DAA) for HCV has led to high rates of HCV eradication. Treatment of patients awaiting liver transplantation (LT) has been controversial. Recent data suggests that DAA treatment may accelerate recurrent HCC. The impact of DAA on delisting for HCC progression or recurrent HCC post-LT has not been well characterized. Methods. A retrospective review of both waitlist patients and LT recipients at a single institution was performed. Patient demographics, HCV treatment, HCC features and treatments, biopsy results, and graft and patient survival were evaluated. Patients on the LT waitlist or who were transplanted between January 2014 and December 2015 were included. Data was collected through December 2017 to have a minimum of two years of follow-up. Results. In the study period, 128 adult LT were performed. 44 patients were HCV+, and 68.2% (N=30) also had HCC. 38.6% (N=17) of HCV+ patients received DAA pre-LT, and 94.1% (N=16/17) achieved sustained virologic response (SVR) pre-LT. Among untreated HCV+ patients who underwent LT, 81.5% (N=22/27) received DAA post-LT, with 82.6% achieving SVR post-LT (N=18/22). 82.1% (N=23/28) of untreated post-LT patients underwent liver biopsy prior to therapy, and 52.2% had at least F1 METAVIR fibrosis. 87.5% (N=14/16) of active waitlist patients received DAA and achieved SVR. HCV eradication did not result in higher rates of delisting for HCC progression. Due to local HCC listing criteria of total tumor volume and AFP, 60% (N=18/30) of HCV+/HCC patients were beyond Milan criteria at the time of LT. Despite this, there was no difference in HCC recurrence rates post-LT, whether patients achieved SVR pre- or post-LT. Conclusions. These data suggest that HCV eradication pre-LT does not significantly impact waitlist time for HCV+ patients with HCC. HCV eradication does not impact rates of delisting for HCC progression or rates of HCC recurrence post-LT.
format Article
id doaj-art-525703fd71894c60896e4bc69ff48655
institution Kabale University
issn 2291-2789
2291-2797
language English
publishDate 2019-01-01
publisher Wiley
record_format Article
series Canadian Journal of Gastroenterology and Hepatology
spelling doaj-art-525703fd71894c60896e4bc69ff486552025-02-03T07:25:53ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972019-01-01201910.1155/2019/25090592509059HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver TransplantationJuliet A. Emamaullee0Mariusz Bral1Glenda Meeberg2Aldo J. Montano-Loza3Vincent G. Bain4Kelly Warren Burak5David Bigam6A. M. James Shapiro7Norman Kneteman8Division of Transplantation, Department of Surgery, University of Alberta, Edmonton, AB, CanadaDivision of Transplantation, Department of Surgery, University of Alberta, Edmonton, AB, CanadaDivision of Transplantation, Department of Surgery, University of Alberta, Edmonton, AB, CanadaDivision of Gastroenterology & Liver Unit, University of Alberta, Edmonton, AB, CanadaDivision of Gastroenterology & Liver Unit, University of Alberta, Edmonton, AB, CanadaDivision of Gastroenterology & Hepatology, University of Calgary, Calgary, AB, CanadaDivision of Transplantation, Department of Surgery, University of Alberta, Edmonton, AB, CanadaDivision of Transplantation, Department of Surgery, University of Alberta, Edmonton, AB, CanadaDivision of Transplantation, Department of Surgery, University of Alberta, Edmonton, AB, CanadaBackground. The introduction of direct-acting antivirals (DAA) for HCV has led to high rates of HCV eradication. Treatment of patients awaiting liver transplantation (LT) has been controversial. Recent data suggests that DAA treatment may accelerate recurrent HCC. The impact of DAA on delisting for HCC progression or recurrent HCC post-LT has not been well characterized. Methods. A retrospective review of both waitlist patients and LT recipients at a single institution was performed. Patient demographics, HCV treatment, HCC features and treatments, biopsy results, and graft and patient survival were evaluated. Patients on the LT waitlist or who were transplanted between January 2014 and December 2015 were included. Data was collected through December 2017 to have a minimum of two years of follow-up. Results. In the study period, 128 adult LT were performed. 44 patients were HCV+, and 68.2% (N=30) also had HCC. 38.6% (N=17) of HCV+ patients received DAA pre-LT, and 94.1% (N=16/17) achieved sustained virologic response (SVR) pre-LT. Among untreated HCV+ patients who underwent LT, 81.5% (N=22/27) received DAA post-LT, with 82.6% achieving SVR post-LT (N=18/22). 82.1% (N=23/28) of untreated post-LT patients underwent liver biopsy prior to therapy, and 52.2% had at least F1 METAVIR fibrosis. 87.5% (N=14/16) of active waitlist patients received DAA and achieved SVR. HCV eradication did not result in higher rates of delisting for HCC progression. Due to local HCC listing criteria of total tumor volume and AFP, 60% (N=18/30) of HCV+/HCC patients were beyond Milan criteria at the time of LT. Despite this, there was no difference in HCC recurrence rates post-LT, whether patients achieved SVR pre- or post-LT. Conclusions. These data suggest that HCV eradication pre-LT does not significantly impact waitlist time for HCV+ patients with HCC. HCV eradication does not impact rates of delisting for HCC progression or rates of HCC recurrence post-LT.http://dx.doi.org/10.1155/2019/2509059
spellingShingle Juliet A. Emamaullee
Mariusz Bral
Glenda Meeberg
Aldo J. Montano-Loza
Vincent G. Bain
Kelly Warren Burak
David Bigam
A. M. James Shapiro
Norman Kneteman
HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation
Canadian Journal of Gastroenterology and Hepatology
title HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation
title_full HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation
title_fullStr HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation
title_full_unstemmed HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation
title_short HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation
title_sort hcv eradication with direct acting antivirals does not impact hcc progression on the waiting list or hcc recurrence after liver transplantation
url http://dx.doi.org/10.1155/2019/2509059
work_keys_str_mv AT julietaemamaullee hcveradicationwithdirectactingantiviralsdoesnotimpacthccprogressiononthewaitinglistorhccrecurrenceafterlivertransplantation
AT mariuszbral hcveradicationwithdirectactingantiviralsdoesnotimpacthccprogressiononthewaitinglistorhccrecurrenceafterlivertransplantation
AT glendameeberg hcveradicationwithdirectactingantiviralsdoesnotimpacthccprogressiononthewaitinglistorhccrecurrenceafterlivertransplantation
AT aldojmontanoloza hcveradicationwithdirectactingantiviralsdoesnotimpacthccprogressiononthewaitinglistorhccrecurrenceafterlivertransplantation
AT vincentgbain hcveradicationwithdirectactingantiviralsdoesnotimpacthccprogressiononthewaitinglistorhccrecurrenceafterlivertransplantation
AT kellywarrenburak hcveradicationwithdirectactingantiviralsdoesnotimpacthccprogressiononthewaitinglistorhccrecurrenceafterlivertransplantation
AT davidbigam hcveradicationwithdirectactingantiviralsdoesnotimpacthccprogressiononthewaitinglistorhccrecurrenceafterlivertransplantation
AT amjamesshapiro hcveradicationwithdirectactingantiviralsdoesnotimpacthccprogressiononthewaitinglistorhccrecurrenceafterlivertransplantation
AT normankneteman hcveradicationwithdirectactingantiviralsdoesnotimpacthccprogressiononthewaitinglistorhccrecurrenceafterlivertransplantation