PARP1-targeted alpha therapy enhances target expression

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Main Authors: Hasan Babazada, Paul Martorano, Hsiaoju Lee, Shuyao Geng, Vandana Batra, John M. Maris, Daniel A. Pryma, Sarah B. Gitto, Michael D. Farwell
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:EJNMMI Research
Subjects:
Online Access:https://doi.org/10.1186/s13550-025-01256-0
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author Hasan Babazada
Paul Martorano
Hsiaoju Lee
Shuyao Geng
Vandana Batra
John M. Maris
Daniel A. Pryma
Sarah B. Gitto
Michael D. Farwell
author_facet Hasan Babazada
Paul Martorano
Hsiaoju Lee
Shuyao Geng
Vandana Batra
John M. Maris
Daniel A. Pryma
Sarah B. Gitto
Michael D. Farwell
author_sort Hasan Babazada
collection DOAJ
description Abstract Graphical abstract
format Article
id doaj-art-524dd77ce12f4f94bc7606d84f3e8ac1
institution DOAJ
issn 2191-219X
language English
publishDate 2025-06-01
publisher SpringerOpen
record_format Article
series EJNMMI Research
spelling doaj-art-524dd77ce12f4f94bc7606d84f3e8ac12025-08-20T03:22:11ZengSpringerOpenEJNMMI Research2191-219X2025-06-011511610.1186/s13550-025-01256-0PARP1-targeted alpha therapy enhances target expressionHasan Babazada0Paul Martorano1Hsiaoju Lee2Shuyao Geng3Vandana Batra4John M. Maris5Daniel A. Pryma6Sarah B. Gitto7Michael D. Farwell8Perelman School of Medicine at the University of PennsylvaniaPerelman School of Medicine at the University of PennsylvaniaPerelman School of Medicine at the University of PennsylvaniaPerelman School of Medicine at the University of PennsylvaniaChildren’s Hospital of PhiladelphiaChildren’s Hospital of PhiladelphiaPerelman School of Medicine at the University of PennsylvaniaPerelman School of Medicine at the University of PennsylvaniaPerelman School of Medicine at the University of PennsylvaniaAbstract Graphical abstracthttps://doi.org/10.1186/s13550-025-01256-0Alpha particle therapyPARP1PET/CTNeuroblastomaDNA damageAstatine-211
spellingShingle Hasan Babazada
Paul Martorano
Hsiaoju Lee
Shuyao Geng
Vandana Batra
John M. Maris
Daniel A. Pryma
Sarah B. Gitto
Michael D. Farwell
PARP1-targeted alpha therapy enhances target expression
EJNMMI Research
Alpha particle therapy
PARP1
PET/CT
Neuroblastoma
DNA damage
Astatine-211
title PARP1-targeted alpha therapy enhances target expression
title_full PARP1-targeted alpha therapy enhances target expression
title_fullStr PARP1-targeted alpha therapy enhances target expression
title_full_unstemmed PARP1-targeted alpha therapy enhances target expression
title_short PARP1-targeted alpha therapy enhances target expression
title_sort parp1 targeted alpha therapy enhances target expression
topic Alpha particle therapy
PARP1
PET/CT
Neuroblastoma
DNA damage
Astatine-211
url https://doi.org/10.1186/s13550-025-01256-0
work_keys_str_mv AT hasanbabazada parp1targetedalphatherapyenhancestargetexpression
AT paulmartorano parp1targetedalphatherapyenhancestargetexpression
AT hsiaojulee parp1targetedalphatherapyenhancestargetexpression
AT shuyaogeng parp1targetedalphatherapyenhancestargetexpression
AT vandanabatra parp1targetedalphatherapyenhancestargetexpression
AT johnmmaris parp1targetedalphatherapyenhancestargetexpression
AT danielapryma parp1targetedalphatherapyenhancestargetexpression
AT sarahbgitto parp1targetedalphatherapyenhancestargetexpression
AT michaeldfarwell parp1targetedalphatherapyenhancestargetexpression