Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken
The aim of this study was to determine the blood and tissue concentrations profile and effect of tilmicosin on some hematological and biochemical parameters in broiler chicken. Fifty clinically healthy Hubbard chickens were orally administered 25 mg/kg BW of tilmicosin once daily for 5 consecutive d...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2014/502872 |
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| author | Mossad Elsayed Ashraf Elkomy Mohamed Aboubakr Mohamed Morad |
| author_facet | Mossad Elsayed Ashraf Elkomy Mohamed Aboubakr Mohamed Morad |
| author_sort | Mossad Elsayed |
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| description | The aim of this study was to determine the blood and tissue concentrations profile and effect of tilmicosin on some hematological and biochemical parameters in broiler chicken. Fifty clinically healthy Hubbard chickens were orally administered 25 mg/kg BW of tilmicosin once daily for 5 consecutive days. Tissue residues of tilmicosin in slaughtered healthy chicken could not be detected by microbiological assay in all tested tissues except in lung (at 96 hours) and liver and kidneys (at 72 hours) after last administration. Tilmicosin caused temporary decrease in the RBCs and WBCs counts and has no effect on hemoglobin (Hb) and packed cell volume concentration (PCV). Also, the effect of tilmicosin on some biochemical parameters was as follows: the concentrations of creatinine, uric acid, electrolytes (sodium, potassium, and calcium), glucose, AST, ALT, ALP, and HDL-cholesterol in the serum of treated chicken did not change in response to the repeated oral administration of tilmicosin. There were only a temporary significant decrease in total protein and albumin concentrations and a significant increase in cholesterol and triglycerides concentrations. Chicken must not be slaughtered before 4 days from the stopping of tilmicosin administration. Tilmicosin makes temporary changes on hematological and biochemical parameters in broiler chicken. |
| format | Article |
| id | doaj-art-52443f4ca7ed4a49af4c2842b426c8a8 |
| institution | OA Journals |
| issn | 2090-8113 2042-0048 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Veterinary Medicine International |
| spelling | doaj-art-52443f4ca7ed4a49af4c2842b426c8a82025-08-20T02:05:42ZengWileyVeterinary Medicine International2090-81132042-00482014-01-01201410.1155/2014/502872502872Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler ChickenMossad Elsayed0Ashraf Elkomy1Mohamed Aboubakr2Mohamed Morad3Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubia 13736, EgyptDepartment of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubia 13736, EgyptDepartment of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubia 13736, EgyptDepartment of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubia 13736, EgyptThe aim of this study was to determine the blood and tissue concentrations profile and effect of tilmicosin on some hematological and biochemical parameters in broiler chicken. Fifty clinically healthy Hubbard chickens were orally administered 25 mg/kg BW of tilmicosin once daily for 5 consecutive days. Tissue residues of tilmicosin in slaughtered healthy chicken could not be detected by microbiological assay in all tested tissues except in lung (at 96 hours) and liver and kidneys (at 72 hours) after last administration. Tilmicosin caused temporary decrease in the RBCs and WBCs counts and has no effect on hemoglobin (Hb) and packed cell volume concentration (PCV). Also, the effect of tilmicosin on some biochemical parameters was as follows: the concentrations of creatinine, uric acid, electrolytes (sodium, potassium, and calcium), glucose, AST, ALT, ALP, and HDL-cholesterol in the serum of treated chicken did not change in response to the repeated oral administration of tilmicosin. There were only a temporary significant decrease in total protein and albumin concentrations and a significant increase in cholesterol and triglycerides concentrations. Chicken must not be slaughtered before 4 days from the stopping of tilmicosin administration. Tilmicosin makes temporary changes on hematological and biochemical parameters in broiler chicken.http://dx.doi.org/10.1155/2014/502872 |
| spellingShingle | Mossad Elsayed Ashraf Elkomy Mohamed Aboubakr Mohamed Morad Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken Veterinary Medicine International |
| title | Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken |
| title_full | Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken |
| title_fullStr | Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken |
| title_full_unstemmed | Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken |
| title_short | Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken |
| title_sort | tissue residues hematological and biochemical effects of tilmicosin in broiler chicken |
| url | http://dx.doi.org/10.1155/2014/502872 |
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