Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals
Abstract Background The gut microbiome is crucial for human health maintenance and disease development, yet limited understanding of its structure and maintenance hinders effective microbiome-based health improvement strategies. We investigated gut microbiome compositional patterns in healthy Korean...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | BMC Biology |
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| Online Access: | https://doi.org/10.1186/s12915-025-02291-y |
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| author | Seungpyo Hong Mi Young Lim Won-Hyong Chung Ji-Hee Shin Young-Do Nam |
| author_facet | Seungpyo Hong Mi Young Lim Won-Hyong Chung Ji-Hee Shin Young-Do Nam |
| author_sort | Seungpyo Hong |
| collection | DOAJ |
| description | Abstract Background The gut microbiome is crucial for human health maintenance and disease development, yet limited understanding of its structure and maintenance hinders effective microbiome-based health improvement strategies. We investigated gut microbiome compositional patterns in healthy Koreans (n = 890), identifying six clusters (I–VI) with unique compositions and host preferences. Results Each cluster had a distinct topological structure within the microbial interaction network, underscoring its diverse roles in maintaining microbial communities. Cluster II, predominated by Bacteroides and Faecalibacterium, was consistently found across individuals and centrally located within the microbial interaction network. Cluster III, mainly composed of Oscillospira and Coprococcus, and IV, dominated by Enterobacteriaceae and Bacteroides fragilis, demonstrated mutually exclusive relationships, reflecting affinities for host clusters with varied dietary patterns and microbial diversity. Clusters V and VI linked different microbial clusters, and cluster I had separate subcommunities. Conclusions This study reveals intricate structures and interactions within microbial communities, offering insights into the gut microbiome ecology and guiding health enhancement strategies. |
| format | Article |
| id | doaj-art-52426e21db1b4a2fbd924aa5c7783dfe |
| institution | Kabale University |
| issn | 1741-7007 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj-art-52426e21db1b4a2fbd924aa5c7783dfe2025-08-20T03:42:00ZengBMCBMC Biology1741-70072025-07-0123111210.1186/s12915-025-02291-yDeciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individualsSeungpyo Hong0Mi Young Lim1Won-Hyong Chung2Ji-Hee Shin3Young-Do Nam4Department of Molecular Biology, Jeonbuk National UniversityPrecision Nutrition Research Group, Food Functionality Research Division, Korea Food Research InstitutePrecision Nutrition Research Group, Food Functionality Research Division, Korea Food Research InstitutePrecision Nutrition Research Group, Food Functionality Research Division, Korea Food Research InstitutePrecision Nutrition Research Group, Food Functionality Research Division, Korea Food Research InstituteAbstract Background The gut microbiome is crucial for human health maintenance and disease development, yet limited understanding of its structure and maintenance hinders effective microbiome-based health improvement strategies. We investigated gut microbiome compositional patterns in healthy Koreans (n = 890), identifying six clusters (I–VI) with unique compositions and host preferences. Results Each cluster had a distinct topological structure within the microbial interaction network, underscoring its diverse roles in maintaining microbial communities. Cluster II, predominated by Bacteroides and Faecalibacterium, was consistently found across individuals and centrally located within the microbial interaction network. Cluster III, mainly composed of Oscillospira and Coprococcus, and IV, dominated by Enterobacteriaceae and Bacteroides fragilis, demonstrated mutually exclusive relationships, reflecting affinities for host clusters with varied dietary patterns and microbial diversity. Clusters V and VI linked different microbial clusters, and cluster I had separate subcommunities. Conclusions This study reveals intricate structures and interactions within microbial communities, offering insights into the gut microbiome ecology and guiding health enhancement strategies.https://doi.org/10.1186/s12915-025-02291-yGut microbiomeMicrobial community structureMicrobial interactionMicrobial ecosystemHuman gut |
| spellingShingle | Seungpyo Hong Mi Young Lim Won-Hyong Chung Ji-Hee Shin Young-Do Nam Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals BMC Biology Gut microbiome Microbial community structure Microbial interaction Microbial ecosystem Human gut |
| title | Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals |
| title_full | Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals |
| title_fullStr | Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals |
| title_full_unstemmed | Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals |
| title_short | Deciphering gut microbiome patterns from host preferences and microbial interactions in healthy Korean individuals |
| title_sort | deciphering gut microbiome patterns from host preferences and microbial interactions in healthy korean individuals |
| topic | Gut microbiome Microbial community structure Microbial interaction Microbial ecosystem Human gut |
| url | https://doi.org/10.1186/s12915-025-02291-y |
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