Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab
Retinal surface macrophages play key roles in the regulation of immune response, maintenance of vitreous clarity, and tissue repair. We examined the variation of parafoveal surface macrophages in a thyroid eye disease (TED) patient before and after treatment with teprotumumab (Tepezza, Horizon thera...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/5275309 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556548846518272 |
|---|---|
| author | Oscar Otero-Marquez Mona Fayad Alexander Pinhas Toco Y. P. Chui Richard B. Rosen Harsha S. Reddy |
| author_facet | Oscar Otero-Marquez Mona Fayad Alexander Pinhas Toco Y. P. Chui Richard B. Rosen Harsha S. Reddy |
| author_sort | Oscar Otero-Marquez |
| collection | DOAJ |
| description | Retinal surface macrophages play key roles in the regulation of immune response, maintenance of vitreous clarity, and tissue repair. We examined the variation of parafoveal surface macrophages in a thyroid eye disease (TED) patient before and after treatment with teprotumumab (Tepezza, Horizon therapeutics). Pre- and posttreatment parafoveal surface macrophages were imaged using clinical en face OCT, and their density was assessed using a novel cell density mapping technique. Pretreatment, surface macrophage cell density was high. Macrophages had a nonuniform spatial distribution, and their appearance was round with few protrusions, consistent with an “activated” state. Posttreatment, cell density decreased. The macrophages were regularly spaced and had a ramified appearance and filopodia-like processes, consistent with a “quiescent” state. Surface macrophage density decreased as the Clinical Activity Score (CAS) decreased with teprotumumab treatment, suggesting a potential association of these cells with an underlying intraocular and retinal inflammatory process previously not described in TED. |
| format | Article |
| id | doaj-art-52413275fd55466eb05ae64a12f553f8 |
| institution | Kabale University |
| issn | 2090-6730 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-52413275fd55466eb05ae64a12f553f82025-02-03T05:44:59ZengWileyCase Reports in Ophthalmological Medicine2090-67302022-01-01202210.1155/2022/5275309Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with TeprotumumabOscar Otero-Marquez0Mona Fayad1Alexander Pinhas2Toco Y. P. Chui3Richard B. Rosen4Harsha S. Reddy5Department of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyRetinal surface macrophages play key roles in the regulation of immune response, maintenance of vitreous clarity, and tissue repair. We examined the variation of parafoveal surface macrophages in a thyroid eye disease (TED) patient before and after treatment with teprotumumab (Tepezza, Horizon therapeutics). Pre- and posttreatment parafoveal surface macrophages were imaged using clinical en face OCT, and their density was assessed using a novel cell density mapping technique. Pretreatment, surface macrophage cell density was high. Macrophages had a nonuniform spatial distribution, and their appearance was round with few protrusions, consistent with an “activated” state. Posttreatment, cell density decreased. The macrophages were regularly spaced and had a ramified appearance and filopodia-like processes, consistent with a “quiescent” state. Surface macrophage density decreased as the Clinical Activity Score (CAS) decreased with teprotumumab treatment, suggesting a potential association of these cells with an underlying intraocular and retinal inflammatory process previously not described in TED.http://dx.doi.org/10.1155/2022/5275309 |
| spellingShingle | Oscar Otero-Marquez Mona Fayad Alexander Pinhas Toco Y. P. Chui Richard B. Rosen Harsha S. Reddy Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab Case Reports in Ophthalmological Medicine |
| title | Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab |
| title_full | Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab |
| title_fullStr | Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab |
| title_full_unstemmed | Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab |
| title_short | Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab |
| title_sort | retinal surface macrophage changes in thyroid eye disease before and after treatment with teprotumumab |
| url | http://dx.doi.org/10.1155/2022/5275309 |
| work_keys_str_mv | AT oscaroteromarquez retinalsurfacemacrophagechangesinthyroideyediseasebeforeandaftertreatmentwithteprotumumab AT monafayad retinalsurfacemacrophagechangesinthyroideyediseasebeforeandaftertreatmentwithteprotumumab AT alexanderpinhas retinalsurfacemacrophagechangesinthyroideyediseasebeforeandaftertreatmentwithteprotumumab AT tocoypchui retinalsurfacemacrophagechangesinthyroideyediseasebeforeandaftertreatmentwithteprotumumab AT richardbrosen retinalsurfacemacrophagechangesinthyroideyediseasebeforeandaftertreatmentwithteprotumumab AT harshasreddy retinalsurfacemacrophagechangesinthyroideyediseasebeforeandaftertreatmentwithteprotumumab |