Peripheral neuropathy in hypereosinophilic syndrome with vasculitis
A 53-year-old woman with non-productive cough of unexplained aetiology for two years, developed a sub-acute symmetrical polyneuropathy involving all four limbs, accompanied by fever, cutaneous rash and myalgia in lower limbs. Laboratory studies revealed a leukocytosis with 70% eosinophils and exclud...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
1991-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000400015&lng=en&tlng=en |
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| _version_ | 1850257467967012864 |
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| author | Osvaldo Nascimento Marcos de Freitas Leila Chimelli Francesco Scaravilli |
| author_facet | Osvaldo Nascimento Marcos de Freitas Leila Chimelli Francesco Scaravilli |
| author_sort | Osvaldo Nascimento |
| collection | DOAJ |
| description | A 53-year-old woman with non-productive cough of unexplained aetiology for two years, developed a sub-acute symmetrical polyneuropathy involving all four limbs, accompanied by fever, cutaneous rash and myalgia in lower limbs. Laboratory studies revealed a leukocytosis with 70% eosinophils and excluded any cause for the hypereosinophilia. An echocardiogram showed increase in thickness of the atrial septum. Motor and sensory conduction velocity were reduced in ulnar and median nerve, and unrecordable in peroneal and tibial nerves. A sural nerve biopsy showed an axonal degeneration involving myelinated and unmyelinated fibers as well as a vasculitis with fibrinoid necrosis and perivascular infiltration of eosinophils. There was considerable clinical and laboratorial improvement with the use of steroids. The differential diagnosis between idiopathic hypereosinophilic syndrome and other disorders known to course with vasculitis and hypereosinophilia is discussed. |
| format | Article |
| id | doaj-art-523f385a60484fb0aa2efafc7b2e6ee0 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 1991-12-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-523f385a60484fb0aa2efafc7b2e6ee02025-08-20T01:56:24ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42271991-12-0149445045510.1590/S0004-282X1991000400015S0004-282X1991000400015Peripheral neuropathy in hypereosinophilic syndrome with vasculitisOsvaldo NascimentoMarcos de FreitasLeila Chimelli0Francesco Scaravilli1Universidade Federal FluminenseInstitute of Neurology, LondonA 53-year-old woman with non-productive cough of unexplained aetiology for two years, developed a sub-acute symmetrical polyneuropathy involving all four limbs, accompanied by fever, cutaneous rash and myalgia in lower limbs. Laboratory studies revealed a leukocytosis with 70% eosinophils and excluded any cause for the hypereosinophilia. An echocardiogram showed increase in thickness of the atrial septum. Motor and sensory conduction velocity were reduced in ulnar and median nerve, and unrecordable in peroneal and tibial nerves. A sural nerve biopsy showed an axonal degeneration involving myelinated and unmyelinated fibers as well as a vasculitis with fibrinoid necrosis and perivascular infiltration of eosinophils. There was considerable clinical and laboratorial improvement with the use of steroids. The differential diagnosis between idiopathic hypereosinophilic syndrome and other disorders known to course with vasculitis and hypereosinophilia is discussed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000400015&lng=en&tlng=en |
| spellingShingle | Osvaldo Nascimento Marcos de Freitas Leila Chimelli Francesco Scaravilli Peripheral neuropathy in hypereosinophilic syndrome with vasculitis Arquivos de Neuro-Psiquiatria |
| title | Peripheral neuropathy in hypereosinophilic syndrome with vasculitis |
| title_full | Peripheral neuropathy in hypereosinophilic syndrome with vasculitis |
| title_fullStr | Peripheral neuropathy in hypereosinophilic syndrome with vasculitis |
| title_full_unstemmed | Peripheral neuropathy in hypereosinophilic syndrome with vasculitis |
| title_short | Peripheral neuropathy in hypereosinophilic syndrome with vasculitis |
| title_sort | peripheral neuropathy in hypereosinophilic syndrome with vasculitis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000400015&lng=en&tlng=en |
| work_keys_str_mv | AT osvaldonascimento peripheralneuropathyinhypereosinophilicsyndromewithvasculitis AT marcosdefreitas peripheralneuropathyinhypereosinophilicsyndromewithvasculitis AT leilachimelli peripheralneuropathyinhypereosinophilicsyndromewithvasculitis AT francescoscaravilli peripheralneuropathyinhypereosinophilicsyndromewithvasculitis |