Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model

Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model

Abstract Background Targeting the blood–brain barrier (BBB) is a key step for effective brain delivery of nanocarriers. We have previously discovered that combinations of BBB nutrient transporter ligands alanine and glutathione (A-GSH), increase the permeability of vesicular and polypeptide nanocarr...

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Main Authors: Mária Mészáros, Thi Ha My Phan, Judit P. Vigh, Gergő Porkoláb, Anna Kocsis, Anikó Szecskó, Emese K. Páli, Nárcisz M. Cser, Tamás F. Polgár, Gábor Kecskeméti, Fruzsina R. Walter, Jens C. Schwamborn, Tamás Janáky, Jeng-Shiung Jan, Szilvia Veszelka, Mária A. Deli
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
In vitro model
Human stem cell derived endothelial cell
Poly(l-glutamic acid)
Dual-targeted nanocarriers
Alanine
Online Access:https://doi.org/10.1186/s12987-025-00623-2
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