GAMG alleviates liver fibrosis through inducing ferroptosis in inflammatory macrophages via the IRF1/SLC7A11 signaling pathway

GAMG alleviates liver fibrosis through inducing ferroptosis in inflammatory macrophages via the IRF1/SLC7A11 signaling pathway

The activation of inflammatory macrophages plays a pivotal role in the development of liver fibrosis (LF). Ferroptosis contributes to the clearance of inflammatory macrophages and the release of profibrotic factors. Glycyrrhetic Acid 3-O-Mono-β-d-glucuronide (GAMG) is a natural compound, the potenti...

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Bibliographic Details
Main Authors: Qing Pang, Shuai Zhou, Yong Wang, Hongtao Pan, Zhicheng Wang, Xiliang Qin, Chao Zhu, Shilei Chen, Huichun Liu, Xiaosi Hu, Hao Jin
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Redox Biology
Subjects:
Glycyrrhetic acid 3-O-Mono-β-d-glucuronide
Liver fibrosis
Ferroptosis
Inflammatory macrophages
IRF1
SLC7A11
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000229
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