Ophthalmic Drug Dosage Forms: Characterisation and Research Methods
This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments, in situ gels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more comp...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/861904 |
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| _version_ | 1849406045083926528 |
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| author | Przemysław Baranowski Bożena Karolewicz Maciej Gajda Janusz Pluta |
| author_facet | Przemysław Baranowski Bożena Karolewicz Maciej Gajda Janusz Pluta |
| author_sort | Przemysław Baranowski |
| collection | DOAJ |
| description | This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments, in situ gels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense mechanisms of the human eye, extending contact time of drug with the cornea, increasing the penetration through the complex anatomical structure of the eye, and providing controlled release of drugs into the eye tissues, which allows reducing the drug application frequency. The rest of the paper describes recommended in vitro and in vivo studies to be performed for various ophthalmic drugs forms in order to assess whether the form is acceptable from the perspective of desired properties and patient’s compliance. |
| format | Article |
| id | doaj-art-5231378fa9ee4deba83f9244f69ee463 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-5231378fa9ee4deba83f9244f69ee4632025-08-20T03:36:31ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/861904861904Ophthalmic Drug Dosage Forms: Characterisation and Research MethodsPrzemysław Baranowski0Bożena Karolewicz1Maciej Gajda2Janusz Pluta3Department of Drug Form Technology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandDepartment of Drug Form Technology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandDepartment of Drug Form Technology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandDepartment of Drug Form Technology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandThis paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments, in situ gels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense mechanisms of the human eye, extending contact time of drug with the cornea, increasing the penetration through the complex anatomical structure of the eye, and providing controlled release of drugs into the eye tissues, which allows reducing the drug application frequency. The rest of the paper describes recommended in vitro and in vivo studies to be performed for various ophthalmic drugs forms in order to assess whether the form is acceptable from the perspective of desired properties and patient’s compliance.http://dx.doi.org/10.1155/2014/861904 |
| spellingShingle | Przemysław Baranowski Bożena Karolewicz Maciej Gajda Janusz Pluta Ophthalmic Drug Dosage Forms: Characterisation and Research Methods The Scientific World Journal |
| title | Ophthalmic Drug Dosage Forms: Characterisation and Research Methods |
| title_full | Ophthalmic Drug Dosage Forms: Characterisation and Research Methods |
| title_fullStr | Ophthalmic Drug Dosage Forms: Characterisation and Research Methods |
| title_full_unstemmed | Ophthalmic Drug Dosage Forms: Characterisation and Research Methods |
| title_short | Ophthalmic Drug Dosage Forms: Characterisation and Research Methods |
| title_sort | ophthalmic drug dosage forms characterisation and research methods |
| url | http://dx.doi.org/10.1155/2014/861904 |
| work_keys_str_mv | AT przemysławbaranowski ophthalmicdrugdosageformscharacterisationandresearchmethods AT bozenakarolewicz ophthalmicdrugdosageformscharacterisationandresearchmethods AT maciejgajda ophthalmicdrugdosageformscharacterisationandresearchmethods AT januszpluta ophthalmicdrugdosageformscharacterisationandresearchmethods |