Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study
BackgroundThe use of multigene panels has significantly increased the likelihood that genetic testing will leave patients with uncertainties regarding test interpretation, implications, and recommendations, which will change over time. Effective longitudinal care models are n...
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JMIR Publications
2025-05-01
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| Series: | JMIR Formative Research |
| Online Access: | https://formative.jmir.org/2025/1/e56282 |
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| author | Phillip Trieu Dominique Fetzer Briana McLeod Kathryn Schweickert Lauren Gutstein Brian Egleston Susan Domchek Linda Fleisher Lynne Wagner Kuang-Yi Wen Cara Cacioppo Jessica E Ebrahimzadeh Dana Falcone Claire Langer Elisabeth Wood Kelsey Karpink Shelby Posen Enida Selmani Angela R Bradbury |
| author_facet | Phillip Trieu Dominique Fetzer Briana McLeod Kathryn Schweickert Lauren Gutstein Brian Egleston Susan Domchek Linda Fleisher Lynne Wagner Kuang-Yi Wen Cara Cacioppo Jessica E Ebrahimzadeh Dana Falcone Claire Langer Elisabeth Wood Kelsey Karpink Shelby Posen Enida Selmani Angela R Bradbury |
| author_sort | Phillip Trieu |
| collection | DOAJ |
| description |
BackgroundThe use of multigene panels has significantly increased the likelihood that genetic testing will leave patients with uncertainties regarding test interpretation, implications, and recommendations, which will change over time. Effective longitudinal care models are needed to provide patients with updated information and to obtain patient and family history updates.
ObjectiveTo bridge this gap, we aimed to develop a patient- and genetic provider–informed digital genetic health portal (GHP), MyCancerGene, to improve longitudinal patient understanding of and responses to genetic testing.
MethodsWe used a 5-step process to develop MyCancerGene. To better understand their interest in and willingness to use a digital GHP, we surveyed 307 patients who completed genetic testing (step 1). We completed qualitative interviews with 10 patients and a focus group with 17 genetic providers to inform the content and function of MyCancerGene (step 2). Next, we developed initial intervention content (step 3) and completed user testing of intervention content with 25 providers and 28 patients (step 4). After developing the prototype intervention, we completed usability testing with 8 patients for their feedback on the final content, functions, and ease of use (step 5).
ResultsIn surveys conducted in step 1, 90% of patients with positive results reported interest in a digital GHP, and over 75% of participants with variants of uncertain significance or uninformative negative results reported similar interest. The most frequently reported advantages among patients were increasing accessibility, convenience, and efficiency (103/224, 46%); keeping genetic information organized (54/224, 24.1%); and increasing or maintaining patient understanding of the information (38/224, 17%). In qualitative interviews (step 2), both patients and genetic providers endorsed the benefit of the tool for updating personal and family history and for providers to share new risk information, test interpretation, or other medical changes. Patient and provider input informed eight key components of the tool: (1) Landing Page, (2) Summary of Care page, (3) My Genetic Test Results page, (4) My Family History page, (5) Provide an Update page, (6) Review an Update page, (7) Resources page, and (8) the Screenings Tracker. They also recommended key functions, including the ability to download and print materials and the inclusion of reminders and engagement functions. Potential challenges identified by patients included privacy and security concerns (67/206, 32.5%) and the potential for electronic information to generate distress (20/206, 9.7%). While patients were comfortable with updates (ie, even variant reclassification upgrades or clinically significant results), 44% (11/25) of genetic providers were uncomfortable sharing variant reclassification upgrades through MyCancerGene.
ConclusionsMyCancerGene, a patient-centered digital GHP, was developed with extensive patient and genetic provider feedback and designed to enhance longitudinal patient understanding of and affective and behavioral responses to genetic testing, particularly in the era of evolving evidence and risk information. |
| format | Article |
| id | doaj-art-5226df5d6ad443d1b1f2df11e7054652 |
| institution | Kabale University |
| issn | 2561-326X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Formative Research |
| spelling | doaj-art-5226df5d6ad443d1b1f2df11e70546522025-08-20T03:49:32ZengJMIR PublicationsJMIR Formative Research2561-326X2025-05-019e5628210.2196/56282Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing StudyPhillip Trieuhttps://orcid.org/0009-0006-2973-4288Dominique Fetzerhttps://orcid.org/0000-0001-6374-0151Briana McLeodhttps://orcid.org/0000-0001-9103-9397Kathryn Schweickerthttps://orcid.org/0009-0009-4571-1256Lauren Gutsteinhttps://orcid.org/0009-0008-3266-9979Brian Eglestonhttps://orcid.org/0000-0002-1633-799XSusan Domchekhttps://orcid.org/0000-0002-5914-7272Linda Fleisherhttps://orcid.org/0000-0002-6911-0756Lynne Wagnerhttps://orcid.org/0000-0001-9685-4796Kuang-Yi Wenhttps://orcid.org/0000-0002-4133-1178Cara Cacioppohttps://orcid.org/0000-0003-4761-7027Jessica E Ebrahimzadehhttps://orcid.org/0000-0002-1505-9625Dana Falconehttps://orcid.org/0009-0001-0112-2603Claire Langerhttps://orcid.org/0009-0000-4064-2989Elisabeth Woodhttps://orcid.org/0000-0002-4734-2214Kelsey Karpinkhttps://orcid.org/0009-0005-2636-0973Shelby Posenhttps://orcid.org/0009-0002-2433-3689Enida Selmanihttps://orcid.org/0009-0002-6784-7874Angela R Bradburyhttps://orcid.org/0000-0001-9607-6402 BackgroundThe use of multigene panels has significantly increased the likelihood that genetic testing will leave patients with uncertainties regarding test interpretation, implications, and recommendations, which will change over time. Effective longitudinal care models are needed to provide patients with updated information and to obtain patient and family history updates. ObjectiveTo bridge this gap, we aimed to develop a patient- and genetic provider–informed digital genetic health portal (GHP), MyCancerGene, to improve longitudinal patient understanding of and responses to genetic testing. MethodsWe used a 5-step process to develop MyCancerGene. To better understand their interest in and willingness to use a digital GHP, we surveyed 307 patients who completed genetic testing (step 1). We completed qualitative interviews with 10 patients and a focus group with 17 genetic providers to inform the content and function of MyCancerGene (step 2). Next, we developed initial intervention content (step 3) and completed user testing of intervention content with 25 providers and 28 patients (step 4). After developing the prototype intervention, we completed usability testing with 8 patients for their feedback on the final content, functions, and ease of use (step 5). ResultsIn surveys conducted in step 1, 90% of patients with positive results reported interest in a digital GHP, and over 75% of participants with variants of uncertain significance or uninformative negative results reported similar interest. The most frequently reported advantages among patients were increasing accessibility, convenience, and efficiency (103/224, 46%); keeping genetic information organized (54/224, 24.1%); and increasing or maintaining patient understanding of the information (38/224, 17%). In qualitative interviews (step 2), both patients and genetic providers endorsed the benefit of the tool for updating personal and family history and for providers to share new risk information, test interpretation, or other medical changes. Patient and provider input informed eight key components of the tool: (1) Landing Page, (2) Summary of Care page, (3) My Genetic Test Results page, (4) My Family History page, (5) Provide an Update page, (6) Review an Update page, (7) Resources page, and (8) the Screenings Tracker. They also recommended key functions, including the ability to download and print materials and the inclusion of reminders and engagement functions. Potential challenges identified by patients included privacy and security concerns (67/206, 32.5%) and the potential for electronic information to generate distress (20/206, 9.7%). While patients were comfortable with updates (ie, even variant reclassification upgrades or clinically significant results), 44% (11/25) of genetic providers were uncomfortable sharing variant reclassification upgrades through MyCancerGene. ConclusionsMyCancerGene, a patient-centered digital GHP, was developed with extensive patient and genetic provider feedback and designed to enhance longitudinal patient understanding of and affective and behavioral responses to genetic testing, particularly in the era of evolving evidence and risk information.https://formative.jmir.org/2025/1/e56282 |
| spellingShingle | Phillip Trieu Dominique Fetzer Briana McLeod Kathryn Schweickert Lauren Gutstein Brian Egleston Susan Domchek Linda Fleisher Lynne Wagner Kuang-Yi Wen Cara Cacioppo Jessica E Ebrahimzadeh Dana Falcone Claire Langer Elisabeth Wood Kelsey Karpink Shelby Posen Enida Selmani Angela R Bradbury Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study JMIR Formative Research |
| title | Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study |
| title_full | Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study |
| title_fullStr | Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study |
| title_full_unstemmed | Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study |
| title_short | Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study |
| title_sort | developing the mycancergene digital health portal to improve patients understanding of germline cancer genetic test results development user and usability testing study |
| url | https://formative.jmir.org/2025/1/e56282 |
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