Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure
Malignant gliomas account for 60% of all primary brain tumors in adults. Glioblastoma Multiforme (GBM) is the most common primary glial tumor with a dismal prognosis and a median survival of approximately 14 months. Extra-neural metastases from primary brain tumors are unusual with an incidence rate...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/1748739 |
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| author | Nitya Prabhakaran Douglas C. Miller N. Scott Litofsky Shellaine R. Frazier |
| author_facet | Nitya Prabhakaran Douglas C. Miller N. Scott Litofsky Shellaine R. Frazier |
| author_sort | Nitya Prabhakaran |
| collection | DOAJ |
| description | Malignant gliomas account for 60% of all primary brain tumors in adults. Glioblastoma Multiforme (GBM) is the most common primary glial tumor with a dismal prognosis and a median survival of approximately 14 months. Extra-neural metastases from primary brain tumors are unusual with an incidence rate of less than 2%. This has been attributed to factors such as short survival, lack of true lymphatics in the CNS, and physical barriers provided by the dura, extracellular matrix, and basement membrane. Although most GBMs occur sporadically, there is a known association with therapeutic radiation exposure and with work in nuclear disaster cleanup. To our knowledge, no case of GBM with metastasis occurring in a patient with occupational radiation exposure currently exists in the literature. In this article, we present a case of GBM with lung metastasis occurring in a 51-year-old Caucasian male, whose history is significant for occupational exposure to ionizing radiation, and review the literature on GBM risk factors and potential mechanisms of metastasis. |
| format | Article |
| id | doaj-art-5220d9aff0f441a28fd2d7050c4306f7 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-5220d9aff0f441a28fd2d7050c4306f72025-08-20T03:36:30ZengWileyCase Reports in Neurological Medicine2090-66682090-66762019-01-01201910.1155/2019/17487391748739Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation ExposureNitya Prabhakaran0Douglas C. Miller1N. Scott Litofsky2Shellaine R. Frazier3Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USADepartment of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USADivision of Neurological Surgery, Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USADepartment of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USAMalignant gliomas account for 60% of all primary brain tumors in adults. Glioblastoma Multiforme (GBM) is the most common primary glial tumor with a dismal prognosis and a median survival of approximately 14 months. Extra-neural metastases from primary brain tumors are unusual with an incidence rate of less than 2%. This has been attributed to factors such as short survival, lack of true lymphatics in the CNS, and physical barriers provided by the dura, extracellular matrix, and basement membrane. Although most GBMs occur sporadically, there is a known association with therapeutic radiation exposure and with work in nuclear disaster cleanup. To our knowledge, no case of GBM with metastasis occurring in a patient with occupational radiation exposure currently exists in the literature. In this article, we present a case of GBM with lung metastasis occurring in a 51-year-old Caucasian male, whose history is significant for occupational exposure to ionizing radiation, and review the literature on GBM risk factors and potential mechanisms of metastasis.http://dx.doi.org/10.1155/2019/1748739 |
| spellingShingle | Nitya Prabhakaran Douglas C. Miller N. Scott Litofsky Shellaine R. Frazier Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure Case Reports in Neurological Medicine |
| title | Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure |
| title_full | Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure |
| title_fullStr | Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure |
| title_full_unstemmed | Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure |
| title_short | Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure |
| title_sort | extraneural metastasis of primary glioma occurring in a setting of occupational ionizing radiation exposure |
| url | http://dx.doi.org/10.1155/2019/1748739 |
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