One Health: potential synergy between infectious and toxic agents. The case of COVID-19
Although the relationship between environmental toxicity and infectious diseases is poorly studied, it is probably more common than is recognized, since the chemical substances could be associated with pre-existing pathologies. For example, some conditions that influence the progression o...
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| Format: | Article |
| Language: | English |
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Academia.edu Journals
2023-10-01
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| Series: | Academia Medicine |
| Online Access: | https://www.academia.edu/108767425/One_Health_potential_synergy_between_infectious_and_toxic_agents_The_case_of_COVID_19 |
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| Summary: | Although the relationship between environmental toxicity and infectious diseases is poorly studied, it is probably more common than is recognized, since the chemical substances could be associated with pre-existing pathologies. For example, some conditions that influence the progression of COVID-19 could have toxicological causes such as cancer, endocrine, neurological, and inflammatory disorders, kidney failure, etc. This contribution highlights that SARS-CoV-2 and some high-volume organic and inorganic chemicals could also exert dysfunctions in the same homeostatic regulators such as HIF-1 and ACE2, with a potential synergistic effect that could affect the severity of COVID-19. This potential synergy is illustrated with adverse effects acquired through bioassays performed with free-living vertebrate embryos indicating that their use as sentinel organisms for environmental contamination could be beneficial both for the ecosystem and human health. |
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| ISSN: | 2994-435X |