Pre-Operative Markers of Post-Operative Complications in Pancreatic Cancer Patients: A Single-Center Study
Abstract Purpose Pancreatic cancer remains a deadly disease with a low survival rate specifically if diagnosed at later stages. Surgery is one of the mainstay treatments for early stage disease but is accompanied by significant mortality and morbidity even in high volume centers. In the present stud...
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Journal of Epidemiology and Global Health |
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| Online Access: | https://doi.org/10.1007/s44197-025-00371-4 |
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| author | Sally Temraz Maya Charafeddine Mohammad Jawad Khalifeh Ali Shamseddine |
| author_facet | Sally Temraz Maya Charafeddine Mohammad Jawad Khalifeh Ali Shamseddine |
| author_sort | Sally Temraz |
| collection | DOAJ |
| description | Abstract Purpose Pancreatic cancer remains a deadly disease with a low survival rate specifically if diagnosed at later stages. Surgery is one of the mainstay treatments for early stage disease but is accompanied by significant mortality and morbidity even in high volume centers. In the present study we wanted to determine the influence of pre-operative weight loss, BMI and liver function tests on postoperative outcomes. Methods Data for patients who underwent pancreatic surgery at the American University of Beirut Medical Center between 1998 and 2017 were analyzed. The data included patient demographics, pathologic diagnosis, stage, nodal involvement, tumor grade, surgical margin, type of adjuvant therapy, liver function tests and post-operative complications. The correlation and p-value were determined by the chi-square test with p-value < 0.05 considered statistically significant. Results The analysis included 236 patients. 63% were males and mean age was 60 years. A total of 96 (41%) patients had significant weight loss prior to surgery and 173 (31%) had a BMI > 30 kg/m2 which were considered obese. Obesity and significant weight loss were associated with increased risk of post-operative complications (P = 0.013 and P = 0.004, respectively). Transaminases and cholestatic liver enzymes were not associated with post-operative complications. Conclusions Assessment and management of nutritional status particularly weight loss and BMI prior to pancreatic cancer surgery may influence postoperative outcomes in this patient population. |
| format | Article |
| id | doaj-art-521563e334bd4bc18e524fbcd9468ed2 |
| institution | OA Journals |
| issn | 2210-6014 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Epidemiology and Global Health |
| spelling | doaj-art-521563e334bd4bc18e524fbcd9468ed22025-08-20T02:15:06ZengSpringerJournal of Epidemiology and Global Health2210-60142025-02-011511710.1007/s44197-025-00371-4Pre-Operative Markers of Post-Operative Complications in Pancreatic Cancer Patients: A Single-Center StudySally Temraz0Maya Charafeddine1Mohammad Jawad Khalifeh2Ali Shamseddine3Department of Internal Medicine, American University of Beirut Medical Center, Riad El SolhDepartment of Internal Medicine, American University of Beirut Medical Center, Riad El SolhDepartment of Surgery, American University of Beirut Medical CenterDepartment of Internal Medicine, American University of Beirut Medical Center, Riad El SolhAbstract Purpose Pancreatic cancer remains a deadly disease with a low survival rate specifically if diagnosed at later stages. Surgery is one of the mainstay treatments for early stage disease but is accompanied by significant mortality and morbidity even in high volume centers. In the present study we wanted to determine the influence of pre-operative weight loss, BMI and liver function tests on postoperative outcomes. Methods Data for patients who underwent pancreatic surgery at the American University of Beirut Medical Center between 1998 and 2017 were analyzed. The data included patient demographics, pathologic diagnosis, stage, nodal involvement, tumor grade, surgical margin, type of adjuvant therapy, liver function tests and post-operative complications. The correlation and p-value were determined by the chi-square test with p-value < 0.05 considered statistically significant. Results The analysis included 236 patients. 63% were males and mean age was 60 years. A total of 96 (41%) patients had significant weight loss prior to surgery and 173 (31%) had a BMI > 30 kg/m2 which were considered obese. Obesity and significant weight loss were associated with increased risk of post-operative complications (P = 0.013 and P = 0.004, respectively). Transaminases and cholestatic liver enzymes were not associated with post-operative complications. Conclusions Assessment and management of nutritional status particularly weight loss and BMI prior to pancreatic cancer surgery may influence postoperative outcomes in this patient population.https://doi.org/10.1007/s44197-025-00371-4Body mass indexLiver function testsPancreatic neoplasmsTransaminasesWeight loss |
| spellingShingle | Sally Temraz Maya Charafeddine Mohammad Jawad Khalifeh Ali Shamseddine Pre-Operative Markers of Post-Operative Complications in Pancreatic Cancer Patients: A Single-Center Study Journal of Epidemiology and Global Health Body mass index Liver function tests Pancreatic neoplasms Transaminases Weight loss |
| title | Pre-Operative Markers of Post-Operative Complications in Pancreatic Cancer Patients: A Single-Center Study |
| title_full | Pre-Operative Markers of Post-Operative Complications in Pancreatic Cancer Patients: A Single-Center Study |
| title_fullStr | Pre-Operative Markers of Post-Operative Complications in Pancreatic Cancer Patients: A Single-Center Study |
| title_full_unstemmed | Pre-Operative Markers of Post-Operative Complications in Pancreatic Cancer Patients: A Single-Center Study |
| title_short | Pre-Operative Markers of Post-Operative Complications in Pancreatic Cancer Patients: A Single-Center Study |
| title_sort | pre operative markers of post operative complications in pancreatic cancer patients a single center study |
| topic | Body mass index Liver function tests Pancreatic neoplasms Transaminases Weight loss |
| url | https://doi.org/10.1007/s44197-025-00371-4 |
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