Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis.
<h4>Background</h4>Periodontal disease (PD) and rheumatoid arthritis (RA) are bone pathologies mediated through immuno-inflammatory mechanisms. The aim of this study was to investigate the serum markers osteopontin (OPN), tumor necrosis factor receptors 1 (TNFR1) and 2 (TNFR2) receptor a...
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| _version_ | 1850076647001161728 |
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| author | Jeneen Panezai Ambereen Ghaffar Mohammad Altamash Per-Erik Engström Anders Larsson |
| author_facet | Jeneen Panezai Ambereen Ghaffar Mohammad Altamash Per-Erik Engström Anders Larsson |
| author_sort | Jeneen Panezai |
| collection | DOAJ |
| description | <h4>Background</h4>Periodontal disease (PD) and rheumatoid arthritis (RA) are bone pathologies mediated through immuno-inflammatory mechanisms. The aim of this study was to investigate the serum markers osteopontin (OPN), tumor necrosis factor receptors 1 (TNFR1) and 2 (TNFR2) receptor activator of nuclear factor-kappa B ligand (RANKL) and RANKL/ osteoprotegerin (OPG) ratio and compare them in PD and RA groups.<h4>Materials & methods</h4>RA (with PD = 19 and without PD = 19), PD (n = 38) and 14 healthy subjects underwent bleeding on probing (BOP) and probing pocket depth (PPD) measurement. PD was defined as PPD measuring ≥5mm registered in ≥3 sites. Marginal bone loss (MBL) for premolars and molars was measured on digital panoramic radiographs. Serum samples were collected from all subjects. OPN, TNFR1, TNFR2 and RANKL were measured by enzyme-linked immunosorbent assays (ELISAs). OPG was measured as part of a multiplex proximity extension assay (PEA).<h4>Results</h4>OPN, TNFR1, TNFR2 and RANKL serum levels were the highest in the RA group with PD, while the RA group without PD were comparable to PD subjects only. The RANKL/OPG ratios were comparable between PD group and both RA groups with (p = 0.051) and without PD (p = 0.37). Serum RANKL levels were associated with MBL (p = 0.008) and PPD ≥ 5mm (p = 0.01).<h4>Conclusion</h4>Peripheral osteoclastogenesis is a feature of periodontal disease with systemic levels of osteoclastogenic markers comparable to the effects observed in rheumatoid arthritis. |
| format | Article |
| id | doaj-art-5213e7d0ec48475bbc46514768e1405f |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5213e7d0ec48475bbc46514768e1405f2025-08-20T02:45:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01136e019723510.1371/journal.pone.0197235Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis.Jeneen PanezaiAmbereen GhaffarMohammad AltamashPer-Erik EngströmAnders Larsson<h4>Background</h4>Periodontal disease (PD) and rheumatoid arthritis (RA) are bone pathologies mediated through immuno-inflammatory mechanisms. The aim of this study was to investigate the serum markers osteopontin (OPN), tumor necrosis factor receptors 1 (TNFR1) and 2 (TNFR2) receptor activator of nuclear factor-kappa B ligand (RANKL) and RANKL/ osteoprotegerin (OPG) ratio and compare them in PD and RA groups.<h4>Materials & methods</h4>RA (with PD = 19 and without PD = 19), PD (n = 38) and 14 healthy subjects underwent bleeding on probing (BOP) and probing pocket depth (PPD) measurement. PD was defined as PPD measuring ≥5mm registered in ≥3 sites. Marginal bone loss (MBL) for premolars and molars was measured on digital panoramic radiographs. Serum samples were collected from all subjects. OPN, TNFR1, TNFR2 and RANKL were measured by enzyme-linked immunosorbent assays (ELISAs). OPG was measured as part of a multiplex proximity extension assay (PEA).<h4>Results</h4>OPN, TNFR1, TNFR2 and RANKL serum levels were the highest in the RA group with PD, while the RA group without PD were comparable to PD subjects only. The RANKL/OPG ratios were comparable between PD group and both RA groups with (p = 0.051) and without PD (p = 0.37). Serum RANKL levels were associated with MBL (p = 0.008) and PPD ≥ 5mm (p = 0.01).<h4>Conclusion</h4>Peripheral osteoclastogenesis is a feature of periodontal disease with systemic levels of osteoclastogenic markers comparable to the effects observed in rheumatoid arthritis.https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0197235/1/pone.0197235.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T134530Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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 |
| spellingShingle | Jeneen Panezai Ambereen Ghaffar Mohammad Altamash Per-Erik Engström Anders Larsson Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. PLoS ONE |
| title | Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. |
| title_full | Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. |
| title_fullStr | Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. |
| title_full_unstemmed | Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. |
| title_short | Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. |
| title_sort | periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis |
| url | https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0197235/1/pone.0197235.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T134530Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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 |
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