Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis
BackgroundIncreased PD-1 expression on CD8+ T cells is considered as a hallmark for T-cell exhaustion, and is thought to be related to the prognosis of cancer patients. However, discrepant results have made it difficult to apply PD-1+CD8+T cells and tumor prognosis to clinical practice. Therefore, w...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1531219/full |
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| author | Zhiyong Wan Meng Cui Jia Yang Dan Liao Junliang Chen Fanmin Li Yin Xiang Zhiwei Cui Yang Yang |
| author_facet | Zhiyong Wan Meng Cui Jia Yang Dan Liao Junliang Chen Fanmin Li Yin Xiang Zhiwei Cui Yang Yang |
| author_sort | Zhiyong Wan |
| collection | DOAJ |
| description | BackgroundIncreased PD-1 expression on CD8+ T cells is considered as a hallmark for T-cell exhaustion, and is thought to be related to the prognosis of cancer patients. However, discrepant results have made it difficult to apply PD-1+CD8+T cells and tumor prognosis to clinical practice. Therefore, we conducted a meta-analysis to evaluate its prognostic value in human cancers.MethodsPRISMA reporting guidelines were strictly followed for conducting the current meta-analysis. The PubMed, Web of Science, Embase databases were searched from inception to November 2024. The pooled Hazard Ratio (HR) along with 95% confidence intervals (CIs) of each article were combined for the associations of PD-1+CD8+ T cells with overall survival (OS), progression- free survival (PFS) and disease-free survival(DFS). Subgroup analyses were performed for area, specimen type, cancer type, treatment, detected method and cancer stage.ResultsA total of 20 studies (23 cohorts, 3086 cancer patients) were included in our study. The expression PD-1+CD8+ T cells in cancer patients tended to predict poor overall survival (OS) (HR: 1.379, 95%CI: 1.084-1.753, p= 0.009), and unfavorable disease-free survival(DFS) (HR: 1.468, 95%CI: 0.931-2.316, p=0.099), though it did not reach statistical significance. Begg’s and Egger’s test demonstrated that no obvious publication bias was exist.ConclusionsHigh PD-1 expression on CD8+ T cells is associated with worse survival outcomes, which can be potentially used as a prognostic marker of malignant tumor. |
| format | Article |
| id | doaj-art-52128da3bfe248e9801bfa413ba90eff |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-52128da3bfe248e9801bfa413ba90eff2025-01-14T05:10:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15312191531219Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysisZhiyong Wan0Meng Cui1Jia Yang2Dan Liao3Junliang Chen4Fanmin Li5Yin Xiang6Zhiwei Cui7Yang Yang8Department of General Practice, People’s Hospital of Leshan, Leshan, ChinaDepartment of Medical Laboratory, People’s Hospital of Leshan, Leshan, ChinaDepartment of Medical Laboratory, People’s Hospital of Leshan, Leshan, ChinaDepartment of Medical Laboratory, People’s Hospital of Leshan, Leshan, ChinaDepartment of Medical Laboratory, People’s Hospital of Leshan, Leshan, ChinaDepartment of General Practice, People’s Hospital of Leshan, Leshan, ChinaDepartment of Medical Laboratory, People’s Hospital of Leshan, Leshan, ChinaDepartment of Medical Laboratory, People’s Hospital of Leshan, Leshan, ChinaDepartment of Medical Laboratory, People’s Hospital of Leshan, Leshan, ChinaBackgroundIncreased PD-1 expression on CD8+ T cells is considered as a hallmark for T-cell exhaustion, and is thought to be related to the prognosis of cancer patients. However, discrepant results have made it difficult to apply PD-1+CD8+T cells and tumor prognosis to clinical practice. Therefore, we conducted a meta-analysis to evaluate its prognostic value in human cancers.MethodsPRISMA reporting guidelines were strictly followed for conducting the current meta-analysis. The PubMed, Web of Science, Embase databases were searched from inception to November 2024. The pooled Hazard Ratio (HR) along with 95% confidence intervals (CIs) of each article were combined for the associations of PD-1+CD8+ T cells with overall survival (OS), progression- free survival (PFS) and disease-free survival(DFS). Subgroup analyses were performed for area, specimen type, cancer type, treatment, detected method and cancer stage.ResultsA total of 20 studies (23 cohorts, 3086 cancer patients) were included in our study. The expression PD-1+CD8+ T cells in cancer patients tended to predict poor overall survival (OS) (HR: 1.379, 95%CI: 1.084-1.753, p= 0.009), and unfavorable disease-free survival(DFS) (HR: 1.468, 95%CI: 0.931-2.316, p=0.099), though it did not reach statistical significance. Begg’s and Egger’s test demonstrated that no obvious publication bias was exist.ConclusionsHigh PD-1 expression on CD8+ T cells is associated with worse survival outcomes, which can be potentially used as a prognostic marker of malignant tumor.https://www.frontiersin.org/articles/10.3389/fonc.2024.1531219/fullPD-1+CD8+ T cellsoverall survivalprogression-free survivaldisease-free survivalcancer |
| spellingShingle | Zhiyong Wan Meng Cui Jia Yang Dan Liao Junliang Chen Fanmin Li Yin Xiang Zhiwei Cui Yang Yang Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis Frontiers in Oncology PD-1+CD8+ T cells overall survival progression-free survival disease-free survival cancer |
| title | Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis |
| title_full | Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis |
| title_fullStr | Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis |
| title_short | Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis |
| title_sort | prognostic significance of programmed cell death 1 expression on cd8 t cells in various cancers a systematic review and meta analysis |
| topic | PD-1+CD8+ T cells overall survival progression-free survival disease-free survival cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1531219/full |
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