Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment
Despite the major advancements in the repertoire for multiple myeloma (MM) treatment, this disease remains a chronically progressive plasma cell malignancy. Drug resistance and high relapse rates complicate the extended treatment strategies. However, the tumor microenvironment (TME) in MM is decisiv...
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MDPI AG
2025-03-01
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| Online Access: | https://www.mdpi.com/2073-4409/14/6/430 |
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| author | Kereshmeh Tasbihi Heiko Bruns |
| author_facet | Kereshmeh Tasbihi Heiko Bruns |
| author_sort | Kereshmeh Tasbihi |
| collection | DOAJ |
| description | Despite the major advancements in the repertoire for multiple myeloma (MM) treatment, this disease remains a chronically progressive plasma cell malignancy. Drug resistance and high relapse rates complicate the extended treatment strategies. However, the tumor microenvironment (TME) in MM is decisive for the success of a therapy or relapse. Aiming to improve the outcome of relapsed and refractory MM patients, Selinexor has entered the drug arsenal of myeloma therapy through the implementation of a novel therapeutic approach by selectively inhibiting the nuclear export receptor Exportin-1 (XPO1). Selinexor leads to the inactivation of cancer-related proteins and induces apoptosis by disrupting the nucleocytoplasmic flow in myeloma cells. While this drug is selectively cytotoxic to neoplastic cells, Selinexor’s immunomodulatory impact on the TME is currently being investigated. The aim of this review was to elucidate Selinexor’s capacity to influence the cell interaction network of the TME from an immunological perspective. Deciphering the complex interplay of highly plastic immune cells provides a contribution to the molecular–biological exploration of disease initiation and progression in MM. Unraveling the novel therapeutic targets of the immunological TME and evaluating the advanced immunotherapeutic regimens implementing Selinexor will shape the future directions of immune-oncotherapy in MM. |
| format | Article |
| id | doaj-art-52124205c2794d52a0146760fbb907fa |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-52124205c2794d52a0146760fbb907fa2025-08-20T02:42:35ZengMDPI AGCells2073-44092025-03-0114643010.3390/cells14060430Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma TreatmentKereshmeh Tasbihi0Heiko Bruns1Department of Medicine 5—Hematology and Oncology, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Medicine 5—Hematology and Oncology, University Hospital Erlangen, 91054 Erlangen, GermanyDespite the major advancements in the repertoire for multiple myeloma (MM) treatment, this disease remains a chronically progressive plasma cell malignancy. Drug resistance and high relapse rates complicate the extended treatment strategies. However, the tumor microenvironment (TME) in MM is decisive for the success of a therapy or relapse. Aiming to improve the outcome of relapsed and refractory MM patients, Selinexor has entered the drug arsenal of myeloma therapy through the implementation of a novel therapeutic approach by selectively inhibiting the nuclear export receptor Exportin-1 (XPO1). Selinexor leads to the inactivation of cancer-related proteins and induces apoptosis by disrupting the nucleocytoplasmic flow in myeloma cells. While this drug is selectively cytotoxic to neoplastic cells, Selinexor’s immunomodulatory impact on the TME is currently being investigated. The aim of this review was to elucidate Selinexor’s capacity to influence the cell interaction network of the TME from an immunological perspective. Deciphering the complex interplay of highly plastic immune cells provides a contribution to the molecular–biological exploration of disease initiation and progression in MM. Unraveling the novel therapeutic targets of the immunological TME and evaluating the advanced immunotherapeutic regimens implementing Selinexor will shape the future directions of immune-oncotherapy in MM.https://www.mdpi.com/2073-4409/14/6/430SelinexorXPOVIOXPO1Exportin-1nuclear exportmultiple myeloma |
| spellingShingle | Kereshmeh Tasbihi Heiko Bruns Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment Cells Selinexor XPOVIO XPO1 Exportin-1 nuclear export multiple myeloma |
| title | Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment |
| title_full | Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment |
| title_fullStr | Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment |
| title_full_unstemmed | Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment |
| title_short | Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment |
| title_sort | selinexor s immunomodulatory impact in advancing multiple myeloma treatment |
| topic | Selinexor XPOVIO XPO1 Exportin-1 nuclear export multiple myeloma |
| url | https://www.mdpi.com/2073-4409/14/6/430 |
| work_keys_str_mv | AT kereshmehtasbihi selinexorsimmunomodulatoryimpactinadvancingmultiplemyelomatreatment AT heikobruns selinexorsimmunomodulatoryimpactinadvancingmultiplemyelomatreatment |