Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients
PurposeThis study aimed to assess the preoperative diagnostic efficacy of magnetic resonance imaging (MRI), computed tomography (CT), and endometrial biopsy for cervical stromal invasion (CSI) in endometrial carcinoma (EC) and to discuss the influencing factors of CSI.Material and methodsA total of...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1548436/full |
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| author | Ying Yang Ying Yang Zhijun Ye Zhijun Ye Yifei Zhao Yifei Zhao Zhengyu Li Zhengyu Li |
| author_facet | Ying Yang Ying Yang Zhijun Ye Zhijun Ye Yifei Zhao Yifei Zhao Zhengyu Li Zhengyu Li |
| author_sort | Ying Yang |
| collection | DOAJ |
| description | PurposeThis study aimed to assess the preoperative diagnostic efficacy of magnetic resonance imaging (MRI), computed tomography (CT), and endometrial biopsy for cervical stromal invasion (CSI) in endometrial carcinoma (EC) and to discuss the influencing factors of CSI.Material and methodsA total of 2,020 patients with EC were retrospectively analyzed in a tertiary hospital. Basic patient information, clinical pathology, and laboratory indicators were collected and analyzed. Using the postoperative pathological diagnosis as the gold standard, the diagnostic efficacies of different preoperative methods were analyzed. Additionally, influencing factors of CSI were examined by univariate and multivariate analyses.ResultsThe sensitivity (Sens.), specificity (Spec.), accuracy (Acc.), diagnostic odds ratio (DOR), Youden’s index, and Kappa value of the MRI vs. CT groups were 49.50% vs. 56.74%, 92.24% vs. 79.09%, 87.70% vs. 76.15%, 11.60 vs. 4.93, 0.42 vs. 0.36, and 0.392 vs. 0.256 (p < 0.001), respectively. The Sens., Spec., Acc., DOR, Youden’s index, and Kappa value of the endometrial biopsy group were 41.74%, 93.25%, 87.08%, 9.97, 0.35, and 0.363 (p < 0.001), respectively. CSI was associated with cancer antigen 125, myometrial invasion, adnexal invasion, parametrial invasion, lymph node metastasis, and progesterone receptor.ConclusionsMRI is relatively superior in assessing CSI, although diagnostic authenticity and consistency were unsatisfactory. Combining MRI and biopsy could improve diagnostic sensitivity, aiding in clinical decision making and prognostic prediction. Comprehensive consideration of high-risk factors for the occurrence of CSI may aid the diagnosis. Preoperative diagnostic methods of CSI in EC still need to be explored further to improve efficiency. |
| format | Article |
| id | doaj-art-521158fffea94af0bb26b041d75842b1 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-521158fffea94af0bb26b041d75842b12025-02-11T05:10:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15484361548436Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patientsYing Yang0Ying Yang1Zhijun Ye2Zhijun Ye3Yifei Zhao4Yifei Zhao5Zhengyu Li6Zhengyu Li7Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Radiology, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaPurposeThis study aimed to assess the preoperative diagnostic efficacy of magnetic resonance imaging (MRI), computed tomography (CT), and endometrial biopsy for cervical stromal invasion (CSI) in endometrial carcinoma (EC) and to discuss the influencing factors of CSI.Material and methodsA total of 2,020 patients with EC were retrospectively analyzed in a tertiary hospital. Basic patient information, clinical pathology, and laboratory indicators were collected and analyzed. Using the postoperative pathological diagnosis as the gold standard, the diagnostic efficacies of different preoperative methods were analyzed. Additionally, influencing factors of CSI were examined by univariate and multivariate analyses.ResultsThe sensitivity (Sens.), specificity (Spec.), accuracy (Acc.), diagnostic odds ratio (DOR), Youden’s index, and Kappa value of the MRI vs. CT groups were 49.50% vs. 56.74%, 92.24% vs. 79.09%, 87.70% vs. 76.15%, 11.60 vs. 4.93, 0.42 vs. 0.36, and 0.392 vs. 0.256 (p < 0.001), respectively. The Sens., Spec., Acc., DOR, Youden’s index, and Kappa value of the endometrial biopsy group were 41.74%, 93.25%, 87.08%, 9.97, 0.35, and 0.363 (p < 0.001), respectively. CSI was associated with cancer antigen 125, myometrial invasion, adnexal invasion, parametrial invasion, lymph node metastasis, and progesterone receptor.ConclusionsMRI is relatively superior in assessing CSI, although diagnostic authenticity and consistency were unsatisfactory. Combining MRI and biopsy could improve diagnostic sensitivity, aiding in clinical decision making and prognostic prediction. Comprehensive consideration of high-risk factors for the occurrence of CSI may aid the diagnosis. Preoperative diagnostic methods of CSI in EC still need to be explored further to improve efficiency.https://www.frontiersin.org/articles/10.3389/fonc.2025.1548436/fullendometrial carcinomacervical stromal invasionMRICTendometrial biopsydiagnosis |
| spellingShingle | Ying Yang Ying Yang Zhijun Ye Zhijun Ye Yifei Zhao Yifei Zhao Zhengyu Li Zhengyu Li Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients Frontiers in Oncology endometrial carcinoma cervical stromal invasion MRI CT endometrial biopsy diagnosis |
| title | Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients |
| title_full | Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients |
| title_fullStr | Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients |
| title_full_unstemmed | Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients |
| title_short | Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients |
| title_sort | comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma a retrospective study of 2 020 patients |
| topic | endometrial carcinoma cervical stromal invasion MRI CT endometrial biopsy diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1548436/full |
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