GABAergic neurons in the ventral tegmental area represent and regulate force vectors
Summary: The ventral tegmental area (VTA), a midbrain region associated with motivated behaviors, contains mostly dopaminergic (DA) neurons and GABAergic (GABA) neurons. Previous work has suggested that VTA GABA neurons provide a reward prediction signal, which is used in computing a reward predicti...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725000841 |
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| author | Qiaochu Jiang Konstantin I. Bakhurin Ryan N. Hughes Bryan Lu Shaolin Ruan Henry H. Yin |
| author_facet | Qiaochu Jiang Konstantin I. Bakhurin Ryan N. Hughes Bryan Lu Shaolin Ruan Henry H. Yin |
| author_sort | Qiaochu Jiang |
| collection | DOAJ |
| description | Summary: The ventral tegmental area (VTA), a midbrain region associated with motivated behaviors, contains mostly dopaminergic (DA) neurons and GABAergic (GABA) neurons. Previous work has suggested that VTA GABA neurons provide a reward prediction signal, which is used in computing a reward prediction error. In this study, by using in vivo electrophysiology and continuous quantification of force exertion in head-fixed mice, we identify distinct populations of VTA GABA neurons that exhibit precise force tuning independently of learning, reward prediction, and outcome valence. Their activity usually precedes force exertion, and selective optogenetic manipulations of these neurons systematically modulate force exertion without influencing reward prediction. Together, these findings show that VTA GABA neurons can continuously regulate force vectors during motivated behavior. |
| format | Article |
| id | doaj-art-520fcdb06ab148f7bee8dff658932249 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-520fcdb06ab148f7bee8dff6589322492025-02-12T05:31:00ZengElsevierCell Reports2211-12472025-02-01442115313GABAergic neurons in the ventral tegmental area represent and regulate force vectorsQiaochu Jiang0Konstantin I. Bakhurin1Ryan N. Hughes2Bryan Lu3Shaolin Ruan4Henry H. Yin5Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USADepartment of Psychology and Neuroscience, Duke University, Durham, NC 27708, USADepartment of Psychology and Neuroscience, Duke University, Durham, NC 27708, USADepartment of Psychology and Neuroscience, Duke University, Durham, NC 27708, USADepartment of Neurobiology, Duke University School of Medicine, Durham, NC 27708, USADepartment of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27708, USA; Corresponding authorSummary: The ventral tegmental area (VTA), a midbrain region associated with motivated behaviors, contains mostly dopaminergic (DA) neurons and GABAergic (GABA) neurons. Previous work has suggested that VTA GABA neurons provide a reward prediction signal, which is used in computing a reward prediction error. In this study, by using in vivo electrophysiology and continuous quantification of force exertion in head-fixed mice, we identify distinct populations of VTA GABA neurons that exhibit precise force tuning independently of learning, reward prediction, and outcome valence. Their activity usually precedes force exertion, and selective optogenetic manipulations of these neurons systematically modulate force exertion without influencing reward prediction. Together, these findings show that VTA GABA neurons can continuously regulate force vectors during motivated behavior.http://www.sciencedirect.com/science/article/pii/S2211124725000841CP: Neuroscience |
| spellingShingle | Qiaochu Jiang Konstantin I. Bakhurin Ryan N. Hughes Bryan Lu Shaolin Ruan Henry H. Yin GABAergic neurons in the ventral tegmental area represent and regulate force vectors Cell Reports CP: Neuroscience |
| title | GABAergic neurons in the ventral tegmental area represent and regulate force vectors |
| title_full | GABAergic neurons in the ventral tegmental area represent and regulate force vectors |
| title_fullStr | GABAergic neurons in the ventral tegmental area represent and regulate force vectors |
| title_full_unstemmed | GABAergic neurons in the ventral tegmental area represent and regulate force vectors |
| title_short | GABAergic neurons in the ventral tegmental area represent and regulate force vectors |
| title_sort | gabaergic neurons in the ventral tegmental area represent and regulate force vectors |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725000841 |
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