Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release
This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow pr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2018-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0030 |
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| _version_ | 1832572272244686848 |
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| author | Mužíková Jitka Komersová Alena Lochař Václav Vildová Lucie Vošoustová Bára Bartoš Martin |
| author_facet | Mužíková Jitka Komersová Alena Lochař Václav Vildová Lucie Vošoustová Bára Bartoš Martin |
| author_sort | Mužíková Jitka |
| collection | DOAJ |
| description | This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. |
| format | Article |
| id | doaj-art-520f74752a90499ab4dfb282a159d51f |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-520f74752a90499ab4dfb282a159d51f2025-02-02T11:05:46ZengSciendoActa Pharmaceutica1846-95582018-09-0168329531110.2478/acph-2018-0030acph-2018-0030Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug releaseMužíková Jitka0Komersová Alena1Lochař Václav2Vildová Lucie3Vošoustová Bára4Bartoš Martin5Department of Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové, Czech RepublicDepartment of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech RepublicDepartment of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech RepublicDepartment of Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové, Czech RepublicDepartment of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech RepublicDepartment of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech RepublicThis paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis.https://doi.org/10.2478/acph-2018-0030coprocessed dry bindermatrix tabletspolyvinyl alcoholenergy profile of compressiontensile strength of tabletsdissolution testing |
| spellingShingle | Mužíková Jitka Komersová Alena Lochař Václav Vildová Lucie Vošoustová Bára Bartoš Martin Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release Acta Pharmaceutica coprocessed dry binder matrix tablets polyvinyl alcohol energy profile of compression tensile strength of tablets dissolution testing |
| title | Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release |
| title_full | Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release |
| title_fullStr | Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release |
| title_full_unstemmed | Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release |
| title_short | Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release |
| title_sort | comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release |
| topic | coprocessed dry binder matrix tablets polyvinyl alcohol energy profile of compression tensile strength of tablets dissolution testing |
| url | https://doi.org/10.2478/acph-2018-0030 |
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