Exploring the role of oral bacteria in oral cancer: a narrative review
Abstract A growing body of research indicates that a wide range of cancer types may correlate with human microbiome components. On the other hand, little is known about the potential contribution of the oral microbiota to oral cancer. However, some oral microbiome components can stimulate different...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01998-2 |
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| author | Hassan Mivehchi Aisan Eskandari-Yaghbastlo Parnian Pour Bahrami Anis Elhami Farbod Faghihinia Seyedeh Tabasom Nejati Kimia Sadat Kazemi Mohsen Nabi Afjadi |
| author_facet | Hassan Mivehchi Aisan Eskandari-Yaghbastlo Parnian Pour Bahrami Anis Elhami Farbod Faghihinia Seyedeh Tabasom Nejati Kimia Sadat Kazemi Mohsen Nabi Afjadi |
| author_sort | Hassan Mivehchi |
| collection | DOAJ |
| description | Abstract A growing body of research indicates that a wide range of cancer types may correlate with human microbiome components. On the other hand, little is known about the potential contribution of the oral microbiota to oral cancer. However, some oral microbiome components can stimulate different tumorigenic processes associated with the development of cancer. In this line, two prevalent oral infections, Porphyromonas gingivalis, and Fusobacterium nucleatum can increase tumor growth. The microbiome can impact the course of the illness through direct interactions with the human body and major modifications to the toxicity and responsiveness to different kinds of cancer therapy. Recent research has demonstrated a relationship between specific phylogenetic groupings and the results of immunotherapy treatment for particular tumor types. Conversely, there has been a recent upsurge in interest in the possibility of using microbes to treat cancer. At the moment, some species, such as Salmonella typhimurium and Clostridium spp., are being explored as possible cancer treatment vectors. Thus, understanding these microbial interactions highlights the importance of maintaining a healthy oral microbiome in preventing oral cancers. From this perspective, this review will discuss the role of the microbiome on oral cancers and their possible application in oral cancer treatment/improvement. |
| format | Article |
| id | doaj-art-520c780d0da24f0380c175b65a19a89c |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-520c780d0da24f0380c175b65a19a89c2025-08-20T02:16:55ZengSpringerDiscover Oncology2730-60112025-02-0116112410.1007/s12672-025-01998-2Exploring the role of oral bacteria in oral cancer: a narrative reviewHassan Mivehchi0Aisan Eskandari-Yaghbastlo1Parnian Pour Bahrami2Anis Elhami3Farbod Faghihinia4Seyedeh Tabasom Nejati5Kimia Sadat Kazemi6Mohsen Nabi Afjadi7Faculty of Dentistry, University of DebrecenSchool of Dentistry, Loma Linda UniversityFaculty of Dentistry, Tehran University of Medical SciencesFaculty of Dentistry, Ahvaz Jundishapur University of Medical SciencesSchool of Dentistry, Yasuj University of Medical SciencesSchool of Dentistry, Hormozgan University of Medical SciencesFaculty of Dentistry, Shahid Beheshti University of Medical SciencesDepartment of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares UniversityAbstract A growing body of research indicates that a wide range of cancer types may correlate with human microbiome components. On the other hand, little is known about the potential contribution of the oral microbiota to oral cancer. However, some oral microbiome components can stimulate different tumorigenic processes associated with the development of cancer. In this line, two prevalent oral infections, Porphyromonas gingivalis, and Fusobacterium nucleatum can increase tumor growth. The microbiome can impact the course of the illness through direct interactions with the human body and major modifications to the toxicity and responsiveness to different kinds of cancer therapy. Recent research has demonstrated a relationship between specific phylogenetic groupings and the results of immunotherapy treatment for particular tumor types. Conversely, there has been a recent upsurge in interest in the possibility of using microbes to treat cancer. At the moment, some species, such as Salmonella typhimurium and Clostridium spp., are being explored as possible cancer treatment vectors. Thus, understanding these microbial interactions highlights the importance of maintaining a healthy oral microbiome in preventing oral cancers. From this perspective, this review will discuss the role of the microbiome on oral cancers and their possible application in oral cancer treatment/improvement.https://doi.org/10.1007/s12672-025-01998-2Oral MicrobiomeOral cancerPorphyromonas gingivalisFusobacterium nucleatum; Clostridium spp |
| spellingShingle | Hassan Mivehchi Aisan Eskandari-Yaghbastlo Parnian Pour Bahrami Anis Elhami Farbod Faghihinia Seyedeh Tabasom Nejati Kimia Sadat Kazemi Mohsen Nabi Afjadi Exploring the role of oral bacteria in oral cancer: a narrative review Discover Oncology Oral Microbiome Oral cancer Porphyromonas gingivalis Fusobacterium nucleatum ; Clostridium spp |
| title | Exploring the role of oral bacteria in oral cancer: a narrative review |
| title_full | Exploring the role of oral bacteria in oral cancer: a narrative review |
| title_fullStr | Exploring the role of oral bacteria in oral cancer: a narrative review |
| title_full_unstemmed | Exploring the role of oral bacteria in oral cancer: a narrative review |
| title_short | Exploring the role of oral bacteria in oral cancer: a narrative review |
| title_sort | exploring the role of oral bacteria in oral cancer a narrative review |
| topic | Oral Microbiome Oral cancer Porphyromonas gingivalis Fusobacterium nucleatum ; Clostridium spp |
| url | https://doi.org/10.1007/s12672-025-01998-2 |
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