Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case–control study
Abstract Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). However, the blood physiological indicators for this eye disease are less reported. Here, we systemically investigated healthy controls, DR patients and DM patients from 2014 to 2022 in Sichuan Provi...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80797-1 |
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| author | Zheng Li Jie Li Jie Zhong Chao Qu Mingyan Du Huaping Tian Haojue Xu Fang Hao Lulin Huang |
| author_facet | Zheng Li Jie Li Jie Zhong Chao Qu Mingyan Du Huaping Tian Haojue Xu Fang Hao Lulin Huang |
| author_sort | Zheng Li |
| collection | DOAJ |
| description | Abstract Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). However, the blood physiological indicators for this eye disease are less reported. Here, we systemically investigated healthy controls, DR patients and DM patients from 2014 to 2022 in Sichuan Provincial People’s Hospital (Chengdu, China). We found the leukocyte count, urea, and direct bilirubin in the DR patients were significantly increased (P < 0.001) compared with the controls. The ratios of aspartate aminotransferase/alanine transaminase, total bilirubin, indirect bilirubin, and red cell distribution width were lower in the DR patients than in the controls (P < 0.001). Notably, Red blood cell count (mean [SD] = 4.54 [0.67] 10E12/L, OR = 0.75) was significantly decreased (P < 0.001), and cystatin C level (mean [SD] = 1.42 [1.13] mg/L, OR = 1.90) was significantly increased in the DR patients compared with the controls (P < 0.001). However, these two indicators were not significantly different between the DM patients and the controls (P = 0.87 and P = 0.14, respectively). Our results showed that red blood cell count and cystatin C are specific biomarkers for DR patients. |
| format | Article |
| id | doaj-art-520842088f464423bbc8854e327ecdbd |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
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| spelling | doaj-art-520842088f464423bbc8854e327ecdbd2025-08-20T02:49:17ZengNature PortfolioScientific Reports2045-23222024-11-011411610.1038/s41598-024-80797-1Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case–control studyZheng Li0Jie Li1Jie Zhong2Chao Qu3Mingyan Du4Huaping Tian5Haojue Xu6Fang Hao7Lulin Huang8Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and TechnologySichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and TechnologyOphthalmology department of Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaOphthalmology department of Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and TechnologySichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and TechnologySichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and TechnologySichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and TechnologySichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and TechnologyAbstract Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). However, the blood physiological indicators for this eye disease are less reported. Here, we systemically investigated healthy controls, DR patients and DM patients from 2014 to 2022 in Sichuan Provincial People’s Hospital (Chengdu, China). We found the leukocyte count, urea, and direct bilirubin in the DR patients were significantly increased (P < 0.001) compared with the controls. The ratios of aspartate aminotransferase/alanine transaminase, total bilirubin, indirect bilirubin, and red cell distribution width were lower in the DR patients than in the controls (P < 0.001). Notably, Red blood cell count (mean [SD] = 4.54 [0.67] 10E12/L, OR = 0.75) was significantly decreased (P < 0.001), and cystatin C level (mean [SD] = 1.42 [1.13] mg/L, OR = 1.90) was significantly increased in the DR patients compared with the controls (P < 0.001). However, these two indicators were not significantly different between the DM patients and the controls (P = 0.87 and P = 0.14, respectively). Our results showed that red blood cell count and cystatin C are specific biomarkers for DR patients.https://doi.org/10.1038/s41598-024-80797-1Diabetic retinopathyDiabetes mellitusRed blood cell countCystatin CBiomarkers |
| spellingShingle | Zheng Li Jie Li Jie Zhong Chao Qu Mingyan Du Huaping Tian Haojue Xu Fang Hao Lulin Huang Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case–control study Scientific Reports Diabetic retinopathy Diabetes mellitus Red blood cell count Cystatin C Biomarkers |
| title | Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case–control study |
| title_full | Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case–control study |
| title_fullStr | Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case–control study |
| title_full_unstemmed | Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case–control study |
| title_short | Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case–control study |
| title_sort | red blood cell count and cystatin c as the specific biomarkers for diabetic retinopathy from diabetes mellitus a case control study |
| topic | Diabetic retinopathy Diabetes mellitus Red blood cell count Cystatin C Biomarkers |
| url | https://doi.org/10.1038/s41598-024-80797-1 |
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