Research Advances on Circular RNA in Malignant Tumors of Digestive System
Circular RNAs (circRNAs) are a class of single-stranded non-coding RNAs that form circular conformations through non-canonical splicing or reverse splicing events. Recently, aberrant expression of circRNA has been observed in several cancers. An increasing number of studies suggested that circRNA is...
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Magazine House of Cancer Research on Prevention and Treatment
2025-05-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1330 |
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| author | Yujuan JIANG Yantao TIAN |
| author_facet | Yujuan JIANG Yantao TIAN |
| author_sort | Yujuan JIANG |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are a class of single-stranded non-coding RNAs that form circular conformations through non-canonical splicing or reverse splicing events. Recently, aberrant expression of circRNA has been observed in several cancers. An increasing number of studies suggested that circRNA is involved in tumor suppression or tumor promotion to varying degrees through diverse molecular mechanisms, highlighting its key role in the occurrence and development of tumors. In this review, we systematically summarize the latest research progress on the function and molecular mechanism of circRNA in malignant tumors of the digestive system. circRNA is expected to be further explored as a target molecule in the treatment of digestive system cancers in the future. |
| format | Article |
| id | doaj-art-52068ca51eea4ef296414560463ffce4 |
| institution | OA Journals |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-05-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-52068ca51eea4ef296414560463ffce42025-08-20T02:16:49ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-05-0152541842210.3971/j.issn.1000-8578.2025.24.133020241330Research Advances on Circular RNA in Malignant Tumors of Digestive SystemYujuan JIANG0Yantao TIAN1Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinses Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinses Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaCircular RNAs (circRNAs) are a class of single-stranded non-coding RNAs that form circular conformations through non-canonical splicing or reverse splicing events. Recently, aberrant expression of circRNA has been observed in several cancers. An increasing number of studies suggested that circRNA is involved in tumor suppression or tumor promotion to varying degrees through diverse molecular mechanisms, highlighting its key role in the occurrence and development of tumors. In this review, we systematically summarize the latest research progress on the function and molecular mechanism of circRNA in malignant tumors of the digestive system. circRNA is expected to be further explored as a target molecule in the treatment of digestive system cancers in the future.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1330circular rnamalignancies of the digestive systemtumorigenesisbiomarkerprognosis |
| spellingShingle | Yujuan JIANG Yantao TIAN Research Advances on Circular RNA in Malignant Tumors of Digestive System Zhongliu Fangzhi Yanjiu circular rna malignancies of the digestive system tumorigenesis biomarker prognosis |
| title | Research Advances on Circular RNA in Malignant Tumors of Digestive System |
| title_full | Research Advances on Circular RNA in Malignant Tumors of Digestive System |
| title_fullStr | Research Advances on Circular RNA in Malignant Tumors of Digestive System |
| title_full_unstemmed | Research Advances on Circular RNA in Malignant Tumors of Digestive System |
| title_short | Research Advances on Circular RNA in Malignant Tumors of Digestive System |
| title_sort | research advances on circular rna in malignant tumors of digestive system |
| topic | circular rna malignancies of the digestive system tumorigenesis biomarker prognosis |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1330 |
| work_keys_str_mv | AT yujuanjiang researchadvancesoncircularrnainmalignanttumorsofdigestivesystem AT yantaotian researchadvancesoncircularrnainmalignanttumorsofdigestivesystem |