The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review
Ankle osteoarthritis (OA) is characterized by intraarticular, activity-related pain. mainly with weight-bearing activities. Several nonoperative therapies remain as the first choices, but there is still no consensus on which is the most effective. This study aimed to systematically synthesize the ev...
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MDPI AG
2024-11-01
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| author | Miguel Ortega-Castillo Abel Gomez-Caceres Ivan Medina-Porqueres |
| author_facet | Miguel Ortega-Castillo Abel Gomez-Caceres Ivan Medina-Porqueres |
| author_sort | Miguel Ortega-Castillo |
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| description | Ankle osteoarthritis (OA) is characterized by intraarticular, activity-related pain. mainly with weight-bearing activities. Several nonoperative therapies remain as the first choices, but there is still no consensus on which is the most effective. This study aimed to systematically synthesize the evidence regarding the effectiveness of PRP in the management of ankle OA. Searches were conducted on PubMed, Cochrane, CINAHL, and SPORTDiscus to find relevant articles from inception to December 2023. Details regarding study characteristics, PRP procedures, and outcomes were extracted. A quality assessment was developed according to Joanna Briggs Institute’s critical appraisal tool. A total of five studies met the inclusion criteria, with 184 patients receiving PRP therapy (mean age 55.7 years, and 51.1% were female). There were three case series, one prospective cohort, and one randomized controlled trial. Pain and function were the most frequently evaluated outcomes among the selected articles. They showed significant improvements in the short-term follow-ups, mostly in patients with II-III-stage ankle OA. There is currently insufficient evidence regarding the effectiveness and safety of PRPs in the treatment of ankle OA. A paucity of high-level research in the literature was also found. |
| format | Article |
| id | doaj-art-52052629bd234e5fa8d57f323edbcb43 |
| institution | OA Journals |
| issn | 2076-3417 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj-art-52052629bd234e5fa8d57f323edbcb432025-08-20T01:53:40ZengMDPI AGApplied Sciences2076-34172024-11-0114221044210.3390/app142210442The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic ReviewMiguel Ortega-Castillo0Abel Gomez-Caceres1Ivan Medina-Porqueres2Department of Physical Therapy, Faculty of Health Sciences, University of Malaga, 29071 Malaga, SpainDepartment of Physical Therapy, Faculty of Health Sciences, University of Malaga, 29071 Malaga, SpainDepartment of Physical Therapy, Faculty of Health Sciences, University of Malaga, 29071 Malaga, SpainAnkle osteoarthritis (OA) is characterized by intraarticular, activity-related pain. mainly with weight-bearing activities. Several nonoperative therapies remain as the first choices, but there is still no consensus on which is the most effective. This study aimed to systematically synthesize the evidence regarding the effectiveness of PRP in the management of ankle OA. Searches were conducted on PubMed, Cochrane, CINAHL, and SPORTDiscus to find relevant articles from inception to December 2023. Details regarding study characteristics, PRP procedures, and outcomes were extracted. A quality assessment was developed according to Joanna Briggs Institute’s critical appraisal tool. A total of five studies met the inclusion criteria, with 184 patients receiving PRP therapy (mean age 55.7 years, and 51.1% were female). There were three case series, one prospective cohort, and one randomized controlled trial. Pain and function were the most frequently evaluated outcomes among the selected articles. They showed significant improvements in the short-term follow-ups, mostly in patients with II-III-stage ankle OA. There is currently insufficient evidence regarding the effectiveness and safety of PRPs in the treatment of ankle OA. A paucity of high-level research in the literature was also found.https://www.mdpi.com/2076-3417/14/22/10442ankle jointosteoarthritisgrowth factorscartilage |
| spellingShingle | Miguel Ortega-Castillo Abel Gomez-Caceres Ivan Medina-Porqueres The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review Applied Sciences ankle joint osteoarthritis growth factors cartilage |
| title | The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review |
| title_full | The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review |
| title_fullStr | The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review |
| title_full_unstemmed | The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review |
| title_short | The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review |
| title_sort | role of platelet rich plasma in the management of ankle osteoarthritis a systematic review |
| topic | ankle joint osteoarthritis growth factors cartilage |
| url | https://www.mdpi.com/2076-3417/14/22/10442 |
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