The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer
N6-methyladenosine (m6A) is the most abundant and well-investigated internal RNA modification in eukaryotic RNAs, affecting its target gene expression by controlling RNA localization, splicing, stability, and translation. m6A modifications are regulated by m6A methyltransferase complex, demethylase,...
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KeAi Communications Co., Ltd.
2025-09-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235230422500056X |
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| author | Li Qiu Shourong Wu Lei Zhang Wenfang Li Debing Xiang Vivi Kasim |
| author_facet | Li Qiu Shourong Wu Lei Zhang Wenfang Li Debing Xiang Vivi Kasim |
| author_sort | Li Qiu |
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| description | N6-methyladenosine (m6A) is the most abundant and well-investigated internal RNA modification in eukaryotic RNAs, affecting its target gene expression by controlling RNA localization, splicing, stability, and translation. m6A modifications are regulated by m6A methyltransferase complex, demethylase, and reading proteins. Insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1), a member of a conserved family of single-stranded RNA-binding proteins, has recently been identified as a vital m6A reading protein. IGF2BP1 is highly expressed in various tumors and is associated with poor prognosis and treatment resistance. Furthermore, previous studies have shown that IGF2BP1 plays critical roles in regulating various cancer hallmarks, including sustained cell proliferation, cell death resistance, activation of invasion and metastasis, deregulated cellular energetics, immune evasion, and unlocking phenotypic plasticity. IGF2BP1 could promote the expression of cancer-related genes by recognizing their m6A sites, thereby altering cell characteristics, and eventually, malignancy. Therefore, IGF2BP1 might be a potential target for tumor diagnosis and anti-tumor therapeutic strategies. This review summarizes the current knowledge on the functional roles and underlying molecular mechanisms of IGF2BP1 in regulating cancer hallmarks. Moreover, we discuss the prospects of IGF2BP1 as a potential tumor diagnosis marker, as well as a potential target for an anti-tumor therapeutic strategy. |
| format | Article |
| id | doaj-art-5202ce82a2dc482cb9d295efaf37a509 |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Genes and Diseases |
| spelling | doaj-art-5202ce82a2dc482cb9d295efaf37a5092025-08-20T03:30:37ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-09-0112510156710.1016/j.gendis.2025.101567The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancerLi Qiu0Shourong Wu1Lei Zhang2Wenfang Li3Debing Xiang4Vivi Kasim5Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400045, ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400045, China; Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 402260, China; Corresponding author. College of Bioengineering, Chongqing University, Chongqing 400044, China.Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400045, ChinaSchool of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi, Xinjiang 830017, ChinaDepartment of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 402260, China; Corresponding author.Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400045, China; Corresponding author.N6-methyladenosine (m6A) is the most abundant and well-investigated internal RNA modification in eukaryotic RNAs, affecting its target gene expression by controlling RNA localization, splicing, stability, and translation. m6A modifications are regulated by m6A methyltransferase complex, demethylase, and reading proteins. Insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1), a member of a conserved family of single-stranded RNA-binding proteins, has recently been identified as a vital m6A reading protein. IGF2BP1 is highly expressed in various tumors and is associated with poor prognosis and treatment resistance. Furthermore, previous studies have shown that IGF2BP1 plays critical roles in regulating various cancer hallmarks, including sustained cell proliferation, cell death resistance, activation of invasion and metastasis, deregulated cellular energetics, immune evasion, and unlocking phenotypic plasticity. IGF2BP1 could promote the expression of cancer-related genes by recognizing their m6A sites, thereby altering cell characteristics, and eventually, malignancy. Therefore, IGF2BP1 might be a potential target for tumor diagnosis and anti-tumor therapeutic strategies. This review summarizes the current knowledge on the functional roles and underlying molecular mechanisms of IGF2BP1 in regulating cancer hallmarks. Moreover, we discuss the prospects of IGF2BP1 as a potential tumor diagnosis marker, as well as a potential target for an anti-tumor therapeutic strategy.http://www.sciencedirect.com/science/article/pii/S235230422500056XCancer hallmarksIGF2BP1m6A modification readerMolecular therapy |
| spellingShingle | Li Qiu Shourong Wu Lei Zhang Wenfang Li Debing Xiang Vivi Kasim The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer Genes and Diseases Cancer hallmarks IGF2BP1 m6A modification reader Molecular therapy |
| title | The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer |
| title_full | The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer |
| title_fullStr | The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer |
| title_full_unstemmed | The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer |
| title_short | The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer |
| title_sort | biological roles and molecular mechanisms of m6a reader igf2bp1 in the hallmarks of cancer |
| topic | Cancer hallmarks IGF2BP1 m6A modification reader Molecular therapy |
| url | http://www.sciencedirect.com/science/article/pii/S235230422500056X |
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