GENETIC MARKERS OF METABOLIC SYNDROME AND CORONARY ATHEROSCLEROSIS IN YAKUTIA INHABITANTS
Aim. Evaluation of the association of rs17465637 gene MIA3 (1q41), rs4804611 gene ZNF627 (19p13.2), rs2549513 (16q23.1), rs619203 gene ROS1 (6q22), rs1333049 (9p21.3), rs1376251 gene TAS2R50 (12p13.2) with arterial hypertension (AH), myocardial infarction (MI), metabolic syndrome...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2017-11-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2374 |
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| Summary: | Aim. Evaluation of the association of rs17465637 gene MIA3 (1q41), rs4804611 gene ZNF627 (19p13.2), rs2549513 (16q23.1), rs619203 gene ROS1 (6q22), rs1333049 (9p21.3), rs1376251 gene TAS2R50 (12p13.2) with arterial hypertension (AH), myocardial infarction (MI), metabolic syndrome (Ms) and coronary atherosclerosis (CAS) in Yakutia inhabitants depending on ethnicity and gender.Material and methods. The results analyzed, of the assessment of the patients with verified CAS (396 males, 60 females) and persons with no clinical signs of CHD (212 males, 271 females) age 45-64 y.o., from native and non-native Yakutia ethnicities. The period of the study: 2007-2010 years. Genomic DNA was extracted from venous blood by phenol-chlorophorm method. Genes polymorphism was tested with PCR real time according to the manual of the equipment (probes TaqMan , Applied Biosystems, USA) on the device ABI 7900HT. In the study, the following mononucleotide polymorphisms were included (MNP): rs17465637 gene MIA3, rs4804611 gene ZNF627, rs2549513 (chr. 16), rs619203 gene ROS1, rs1333049 (chr. 9), rs1376251 gene TAS2R50. For diagnosis of Ms, IDF 2005 criteria were applied.Results. Association of AH was found in native inhabitants — males with genotype СС rs1376251 gene TAS2R50 (p=0,004), in females with АА rs2549513 (chr. 16) (p=0,028) and rs4804611 gene ZNF627 (p=0,033); in non-native inhabitants (regardless the gender and in females) — rs619203 gene ROS1 (p=0,000). Relation was found for MI in native inhabitants with genotype ТТ rs1376251 gene TAS2R50 (p=0,005); in non-native heterozygous males rs17465637 gene MIA3 (p=0,047) and rs619203 gene ROS1 (p=0,009), as homozygous АА rs2549513 (chr. 16) (p=0,041). The associations were found for Ms among native inhabitants in male carriers of genotypes АА rs17465637 gene MIA3 (p=0,029) and heterozygous rs4804611 gene ZNF627 (p=0,034), as heterozygous regardless the gender rs2549513 (chr. 16) (p=0,016) in non-native inhabitants in male (p=0,016) and female (p=0,005) carriers of GG rs619203 gene ROS1 and heterozygous females rs1333049 (chr. 9) (p=0,031). With the CAS, the association found in native heterozygous males rs17465637 gene MIA3 (p=0,040) and carriers of ТТ rs1376251 gene TAS2R50 (p=0,006); in non-native males with CG rs619203 gene ROS1 (p=0,020), in nonnative females with АА rs4804611 gene ZNF627 (p=0,008), heterozygous rs1333049 (chr. 9) (p=0,030) and rs2549513 (chr. 16) (p=0,024).Conclusion. First time in inhabitants of Yakutia REpublic, the genome wide results replicated, of the association study with AH, MI, Ms, CAS. These genetic markers can be utilized for the risk assessment of cardiovascular diseases in Russian (Yakutia) population. |
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| ISSN: | 1560-4071 2618-7620 |