Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1
We report a case of autoimmune polyglandular syndrome type 1 (APS1) complicated by severe vascular insufficiency due to diffuse vascular calcification. APS1 is characterised clinically by multiple autoimmune conditions and development of at least two components of the triad of mucocutaneous candidia...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/281758 |
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| author | I. R. Wallace V. McConnell P. M. Bell J. R. Lindsay |
| author_facet | I. R. Wallace V. McConnell P. M. Bell J. R. Lindsay |
| author_sort | I. R. Wallace |
| collection | DOAJ |
| description | We report a case of autoimmune polyglandular syndrome type 1 (APS1) complicated by severe vascular insufficiency due to diffuse vascular calcification. APS1 is characterised clinically by multiple autoimmune conditions and development of at least two components of the triad of mucocutaneous candidiasis, hypoparathyroidism, and autoimmune adrenal insufficiency. We highlight the problems in current serum calcium monitoring methods and suggest that fluctuations in serum calcium concentrations due to difficulties treating hypoparathyroidism may have contributed to the vascular calcification seen in this case. |
| format | Article |
| id | doaj-art-51fca806519342e0ae726d45b8d0b074 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-51fca806519342e0ae726d45b8d0b0742025-08-20T03:36:27ZengWileyCase Reports in Endocrinology2090-65012090-651X2011-01-01201110.1155/2011/281758281758Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1I. R. Wallace0V. McConnell1P. M. Bell2J. R. Lindsay3Department of Endocrinology and Diabetes, Altnagelvin Area Hospital, Londonderry BT47 6SB, UKNorthern Ireland Regional Genetics Service, Belfast City Hospital, Belfast BT9 7AB, UKRegional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UKDepartment of Endocrinology and Diabetes, Altnagelvin Area Hospital, Londonderry BT47 6SB, UKWe report a case of autoimmune polyglandular syndrome type 1 (APS1) complicated by severe vascular insufficiency due to diffuse vascular calcification. APS1 is characterised clinically by multiple autoimmune conditions and development of at least two components of the triad of mucocutaneous candidiasis, hypoparathyroidism, and autoimmune adrenal insufficiency. We highlight the problems in current serum calcium monitoring methods and suggest that fluctuations in serum calcium concentrations due to difficulties treating hypoparathyroidism may have contributed to the vascular calcification seen in this case.http://dx.doi.org/10.1155/2011/281758 |
| spellingShingle | I. R. Wallace V. McConnell P. M. Bell J. R. Lindsay Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1 Case Reports in Endocrinology |
| title | Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1 |
| title_full | Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1 |
| title_fullStr | Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1 |
| title_full_unstemmed | Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1 |
| title_short | Challenges in Management of Primary Hypoparathyroidism Associated with Autoimmune Polyglandular Syndrome Type 1 |
| title_sort | challenges in management of primary hypoparathyroidism associated with autoimmune polyglandular syndrome type 1 |
| url | http://dx.doi.org/10.1155/2011/281758 |
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