The Use of Intrinsic Disorder and Phosphorylation by Oncogenic Viral Proteins to Dysregulate the Host Cell Cycle Through Interaction with pRb
Approximately 15% of cancers worldwide are caused by oncogenic viruses. These infectious agents utilize multiple strategies to dysregulate their host cells as a means of viral reproduction. While this typically involves a small number of viral oncoproteins known to interact with a myriad of host cel...
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| Format: | Article |
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MDPI AG
2025-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/6/835 |
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| author | Heidi Kast-Woelbern Sarah K. Martinho Kayla T. Julio Audrey M. Vazzana Abbey E. Mandagie Ariane L. Jansma |
| author_facet | Heidi Kast-Woelbern Sarah K. Martinho Kayla T. Julio Audrey M. Vazzana Abbey E. Mandagie Ariane L. Jansma |
| author_sort | Heidi Kast-Woelbern |
| collection | DOAJ |
| description | Approximately 15% of cancers worldwide are caused by oncogenic viruses. These infectious agents utilize multiple strategies to dysregulate their host cells as a means of viral reproduction. While this typically involves a small number of viral oncoproteins known to interact with a myriad of host cell proteins, direct binding with the tumor suppressor retinoblastoma protein (pRb) as a means to dysregulate the cell cycle appears to be a common mechanism among most known oncogenic viruses. This review evaluates the shared structural themes of binding motif, intrinsic disorder, and viral oncoprotein phosphorylation, utilized by eight different oncogenic viruses for the subjugation of pRb. Cancer caused by oncogenic viruses represents one of the few potentially preventable forms of cancer. The more we understand the common strategies used by these infectious agents, the better equipped we will be to further optimize vaccination and therapeutic strategies to fight them. |
| format | Article |
| id | doaj-art-51f7748dccd245a2a1a55a985aeb4153 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-51f7748dccd245a2a1a55a985aeb41532025-08-20T03:26:56ZengMDPI AGViruses1999-49152025-06-0117683510.3390/v17060835The Use of Intrinsic Disorder and Phosphorylation by Oncogenic Viral Proteins to Dysregulate the Host Cell Cycle Through Interaction with pRbHeidi Kast-Woelbern0Sarah K. Martinho1Kayla T. Julio2Audrey M. Vazzana3Abbey E. Mandagie4Ariane L. Jansma5Department of Biology, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, CA 92106, USADepartment of Biology, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, CA 92106, USADepartment of Biology, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, CA 92106, USADepartment of Chemistry, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, CA 92106, USADepartment of Chemistry, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, CA 92106, USADepartment of Chemistry, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, CA 92106, USAApproximately 15% of cancers worldwide are caused by oncogenic viruses. These infectious agents utilize multiple strategies to dysregulate their host cells as a means of viral reproduction. While this typically involves a small number of viral oncoproteins known to interact with a myriad of host cell proteins, direct binding with the tumor suppressor retinoblastoma protein (pRb) as a means to dysregulate the cell cycle appears to be a common mechanism among most known oncogenic viruses. This review evaluates the shared structural themes of binding motif, intrinsic disorder, and viral oncoprotein phosphorylation, utilized by eight different oncogenic viruses for the subjugation of pRb. Cancer caused by oncogenic viruses represents one of the few potentially preventable forms of cancer. The more we understand the common strategies used by these infectious agents, the better equipped we will be to further optimize vaccination and therapeutic strategies to fight them.https://www.mdpi.com/1999-4915/17/6/835oncogenic virusintrinsically disordered proteinphosphorylation |
| spellingShingle | Heidi Kast-Woelbern Sarah K. Martinho Kayla T. Julio Audrey M. Vazzana Abbey E. Mandagie Ariane L. Jansma The Use of Intrinsic Disorder and Phosphorylation by Oncogenic Viral Proteins to Dysregulate the Host Cell Cycle Through Interaction with pRb Viruses oncogenic virus intrinsically disordered protein phosphorylation |
| title | The Use of Intrinsic Disorder and Phosphorylation by Oncogenic Viral Proteins to Dysregulate the Host Cell Cycle Through Interaction with pRb |
| title_full | The Use of Intrinsic Disorder and Phosphorylation by Oncogenic Viral Proteins to Dysregulate the Host Cell Cycle Through Interaction with pRb |
| title_fullStr | The Use of Intrinsic Disorder and Phosphorylation by Oncogenic Viral Proteins to Dysregulate the Host Cell Cycle Through Interaction with pRb |
| title_full_unstemmed | The Use of Intrinsic Disorder and Phosphorylation by Oncogenic Viral Proteins to Dysregulate the Host Cell Cycle Through Interaction with pRb |
| title_short | The Use of Intrinsic Disorder and Phosphorylation by Oncogenic Viral Proteins to Dysregulate the Host Cell Cycle Through Interaction with pRb |
| title_sort | use of intrinsic disorder and phosphorylation by oncogenic viral proteins to dysregulate the host cell cycle through interaction with prb |
| topic | oncogenic virus intrinsically disordered protein phosphorylation |
| url | https://www.mdpi.com/1999-4915/17/6/835 |
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