Sensitivity and Specificity of the ECAS in Parkinson’s Disease and Progressive Supranuclear Palsy
Disentangling Parkinson’s disease (PD) and progressive supranuclear palsy (PSP) may be a diagnostic challenge. Cognitive signs may be useful, but existing screens are often insufficiently sensitive or unsuitable for assessing people with motor disorders. We investigated whether the newly developed E...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/2426012 |
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| author | Jennifer A. Foley Elaine H. Niven Andrew Paget Kailash P. Bhatia Simon F. Farmer Paul R. Jarman Patricia Limousin Thomas T. Warner Huw R. Morris Thomas H. Bak Sharon Abrahams Lisa Cipolotti |
| author_facet | Jennifer A. Foley Elaine H. Niven Andrew Paget Kailash P. Bhatia Simon F. Farmer Paul R. Jarman Patricia Limousin Thomas T. Warner Huw R. Morris Thomas H. Bak Sharon Abrahams Lisa Cipolotti |
| author_sort | Jennifer A. Foley |
| collection | DOAJ |
| description | Disentangling Parkinson’s disease (PD) and progressive supranuclear palsy (PSP) may be a diagnostic challenge. Cognitive signs may be useful, but existing screens are often insufficiently sensitive or unsuitable for assessing people with motor disorders. We investigated whether the newly developed ECAS, designed to be used with people with even severe motor disability, was sensitive to the cognitive impairment seen in PD and PSP and able to distinguish between these two disorders. Thirty patients with PD, 11 patients with PSP, and 40 healthy controls were assessed using the ECAS, as well as an extensive neuropsychological assessment. The ECAS detected cognitive impairment in 30% of the PD patients, all of whom fulfilled the diagnostic criteria for mild cognitive impairment. The ECAS was also able to detect cognitive impairment in PSP patients, with 81.8% of patients performing in the impaired range. The ECAS total score distinguished between the patients with PSP and healthy controls with high sensitivity (91.0) and specificity (86.8). Importantly, the ECAS was also able to distinguish between the two syndromes, with the measures of verbal fluency offering high sensitivity (82.0) and specificity (80.0). In sum, the ECAS is a quick, simple, and inexpensive test that can be used to support the differential diagnosis of PSP. |
| format | Article |
| id | doaj-art-51f7619844cb45af8cb11e731202ec7f |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-51f7619844cb45af8cb11e731202ec7f2025-08-20T03:36:27ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/24260122426012Sensitivity and Specificity of the ECAS in Parkinson’s Disease and Progressive Supranuclear PalsyJennifer A. Foley0Elaine H. Niven1Andrew Paget2Kailash P. Bhatia3Simon F. Farmer4Paul R. Jarman5Patricia Limousin6Thomas T. Warner7Huw R. Morris8Thomas H. Bak9Sharon Abrahams10Lisa Cipolotti11National Hospital for Neurology and Neurosurgery, Queen Square, London, UKSchool of Social Sciences (Psychology), University of Dundee, Dundee, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKHuman Cognitive Neuroscience–PPLS, University of Edinburgh, Edinburgh, UKHuman Cognitive Neuroscience–PPLS, University of Edinburgh, Edinburgh, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKDisentangling Parkinson’s disease (PD) and progressive supranuclear palsy (PSP) may be a diagnostic challenge. Cognitive signs may be useful, but existing screens are often insufficiently sensitive or unsuitable for assessing people with motor disorders. We investigated whether the newly developed ECAS, designed to be used with people with even severe motor disability, was sensitive to the cognitive impairment seen in PD and PSP and able to distinguish between these two disorders. Thirty patients with PD, 11 patients with PSP, and 40 healthy controls were assessed using the ECAS, as well as an extensive neuropsychological assessment. The ECAS detected cognitive impairment in 30% of the PD patients, all of whom fulfilled the diagnostic criteria for mild cognitive impairment. The ECAS was also able to detect cognitive impairment in PSP patients, with 81.8% of patients performing in the impaired range. The ECAS total score distinguished between the patients with PSP and healthy controls with high sensitivity (91.0) and specificity (86.8). Importantly, the ECAS was also able to distinguish between the two syndromes, with the measures of verbal fluency offering high sensitivity (82.0) and specificity (80.0). In sum, the ECAS is a quick, simple, and inexpensive test that can be used to support the differential diagnosis of PSP.http://dx.doi.org/10.1155/2018/2426012 |
| spellingShingle | Jennifer A. Foley Elaine H. Niven Andrew Paget Kailash P. Bhatia Simon F. Farmer Paul R. Jarman Patricia Limousin Thomas T. Warner Huw R. Morris Thomas H. Bak Sharon Abrahams Lisa Cipolotti Sensitivity and Specificity of the ECAS in Parkinson’s Disease and Progressive Supranuclear Palsy Parkinson's Disease |
| title | Sensitivity and Specificity of the ECAS in Parkinson’s Disease and Progressive Supranuclear Palsy |
| title_full | Sensitivity and Specificity of the ECAS in Parkinson’s Disease and Progressive Supranuclear Palsy |
| title_fullStr | Sensitivity and Specificity of the ECAS in Parkinson’s Disease and Progressive Supranuclear Palsy |
| title_full_unstemmed | Sensitivity and Specificity of the ECAS in Parkinson’s Disease and Progressive Supranuclear Palsy |
| title_short | Sensitivity and Specificity of the ECAS in Parkinson’s Disease and Progressive Supranuclear Palsy |
| title_sort | sensitivity and specificity of the ecas in parkinson s disease and progressive supranuclear palsy |
| url | http://dx.doi.org/10.1155/2018/2426012 |
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