Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity
Background/Objectives: Severe obesity (BMI > 40 kg/m<sup>2</sup>) has a severe influence on vascular health and reproduction. This study looks at how bariatric surgery affects endothelial nitric oxide synthase (eNOS) expression and reproductive hormone regulation across different foll...
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2024-12-01
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| author | Charalampos Voros Despoina Mavrogianni Kyriakos Bananis Alexios Karakasis Anthi-Maria Papahliou Vasileios Topalis Antonia Varthaliti Raphail Mantzioros Panagiota Kondili Menelaos Darlas Regina Sotiropoulou Diamantis Athanasiou Dimitris Mathiopoulos Panagiotis Antsaklis Dimitrios Loutradis Georgios Daskalakis |
| author_facet | Charalampos Voros Despoina Mavrogianni Kyriakos Bananis Alexios Karakasis Anthi-Maria Papahliou Vasileios Topalis Antonia Varthaliti Raphail Mantzioros Panagiota Kondili Menelaos Darlas Regina Sotiropoulou Diamantis Athanasiou Dimitris Mathiopoulos Panagiotis Antsaklis Dimitrios Loutradis Georgios Daskalakis |
| author_sort | Charalampos Voros |
| collection | DOAJ |
| description | Background/Objectives: Severe obesity (BMI > 40 kg/m<sup>2</sup>) has a severe influence on vascular health and reproduction. This study looks at how bariatric surgery affects endothelial nitric oxide synthase (eNOS) expression and reproductive hormone regulation across different follicle-stimulating hormone receptor (FSHR) polymorphism groups in women with extreme obesity. Methods: Twenty-nine women with extreme obesity had bariatric surgery. Pre- and post-surgery levels of eNOS and reproductive hormones such as follicle-stimulating hormone (FSH), sex hormone-binding globulin (SHBG), anti-Müllerian hormone (AMH), and antral follicle count (AFC) were assessed. Patients were divided into three FSHR polymorphism groups (Ser/Ser, Asn/Asn, and Ser/Asn), and results were compared between them. Statistical techniques were used to determine changes and relationships. Results: Bariatric surgery led to substantial increases in eNOS expression across all FSHR polymorphism groups (<i>p</i> < 0.0001), with the Ser/Ser group exhibiting the most variability. Prior to surgery, the Ser/Ser group had substantially higher FSH levels (7.41 ± 0.60 mIU/mL) than the Asn/Asn group (5.20 ± 0.63 mIU/mL, <i>p</i> < 0.001). Following surgery, FSH levels rose in the Ser/Ser group (9.45 ± 0.87 mIU/mL), with significant differences between the Ser/Ser and Ser/Asn groups (mean difference = 0.97, <i>p</i> = 0.019). SHBG levels had a negative connection with eNOS expression after surgery (r = −0.365, <i>p</i> = 0.049). AMH and AFC remained constant throughout polymorphism groups. BMI decreased uniformly, with an average of 15.2 ± 1.8 kg six months after surgery. Conclusions: Bariatric surgery improves vascular health and regulates reproductive hormones, especially in individuals with the Ser/Ser genotype. These findings indicate the possibility of combining genetic testing and bariatric therapies to improve infertility treatment in obese women. |
| format | Article |
| id | doaj-art-51f5b32546e84d5e8854a59e71315c45 |
| institution | Kabale University |
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| language | English |
| publishDate | 2024-12-01 |
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| series | Biomedicines |
| spelling | doaj-art-51f5b32546e84d5e8854a59e71315c452025-01-24T13:23:54ZengMDPI AGBiomedicines2227-90592024-12-011316710.3390/biomedicines13010067Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe ObesityCharalampos Voros0Despoina Mavrogianni1Kyriakos Bananis2Alexios Karakasis3Anthi-Maria Papahliou4Vasileios Topalis5Antonia Varthaliti6Raphail Mantzioros7Panagiota Kondili8Menelaos Darlas9Regina Sotiropoulou10Diamantis Athanasiou11Dimitris Mathiopoulos12Panagiotis Antsaklis13Dimitrios Loutradis14Georgios Daskalakis151st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, GreeceKing’s College Hospitals NHS Foundation Trust, London SE5 9RS, UK1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, GreeceDepartment of Internal Medicine, Hospital of Thun, 3600 Thun, Switzerland1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, GreeceIVF Athens Reproduction Center V. Athanasiou, 15123 Maroussi, GreeceRea Maternity Hospital S.A., Avenue Siggrou 383 & Pentelis 17, P. Faliro, 17564 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, GreeceFertility Institute-Assisted Reproduction Unit, Paster 15, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, GreeceBackground/Objectives: Severe obesity (BMI > 40 kg/m<sup>2</sup>) has a severe influence on vascular health and reproduction. This study looks at how bariatric surgery affects endothelial nitric oxide synthase (eNOS) expression and reproductive hormone regulation across different follicle-stimulating hormone receptor (FSHR) polymorphism groups in women with extreme obesity. Methods: Twenty-nine women with extreme obesity had bariatric surgery. Pre- and post-surgery levels of eNOS and reproductive hormones such as follicle-stimulating hormone (FSH), sex hormone-binding globulin (SHBG), anti-Müllerian hormone (AMH), and antral follicle count (AFC) were assessed. Patients were divided into three FSHR polymorphism groups (Ser/Ser, Asn/Asn, and Ser/Asn), and results were compared between them. Statistical techniques were used to determine changes and relationships. Results: Bariatric surgery led to substantial increases in eNOS expression across all FSHR polymorphism groups (<i>p</i> < 0.0001), with the Ser/Ser group exhibiting the most variability. Prior to surgery, the Ser/Ser group had substantially higher FSH levels (7.41 ± 0.60 mIU/mL) than the Asn/Asn group (5.20 ± 0.63 mIU/mL, <i>p</i> < 0.001). Following surgery, FSH levels rose in the Ser/Ser group (9.45 ± 0.87 mIU/mL), with significant differences between the Ser/Ser and Ser/Asn groups (mean difference = 0.97, <i>p</i> = 0.019). SHBG levels had a negative connection with eNOS expression after surgery (r = −0.365, <i>p</i> = 0.049). AMH and AFC remained constant throughout polymorphism groups. BMI decreased uniformly, with an average of 15.2 ± 1.8 kg six months after surgery. Conclusions: Bariatric surgery improves vascular health and regulates reproductive hormones, especially in individuals with the Ser/Ser genotype. These findings indicate the possibility of combining genetic testing and bariatric therapies to improve infertility treatment in obese women.https://www.mdpi.com/2227-9059/13/1/67infertilitybariatric surgeryFSHRAsn680SerENOSoxidate stress |
| spellingShingle | Charalampos Voros Despoina Mavrogianni Kyriakos Bananis Alexios Karakasis Anthi-Maria Papahliou Vasileios Topalis Antonia Varthaliti Raphail Mantzioros Panagiota Kondili Menelaos Darlas Regina Sotiropoulou Diamantis Athanasiou Dimitris Mathiopoulos Panagiotis Antsaklis Dimitrios Loutradis Georgios Daskalakis Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity Biomedicines infertility bariatric surgery FSHR Asn680Ser ENOS oxidate stress |
| title | Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity |
| title_full | Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity |
| title_fullStr | Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity |
| title_full_unstemmed | Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity |
| title_short | Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity |
| title_sort | bariatric surgery as a molecular modulator the role of fshr polymorphisms in enhancing enos expression and reproductive hormone dynamics in women with severe obesity |
| topic | infertility bariatric surgery FSHR Asn680Ser ENOS oxidate stress |
| url | https://www.mdpi.com/2227-9059/13/1/67 |
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