Coagulation profiles and platelet parameters among preeclampsia, eclampsia, and normotensive pregnant women attending Comprehensive Specialized Hospital maternity wards, Northwest Ethiopia.
<h4>Background</h4>Hypertensive disorders of pregnancy affect about 10% of all pregnant women worldwide. A variety of hematological abnormalities may occur in women with pregnancy-induced hypertension. Thus, we aimed to compare coagulation profiles and platelet parameters among preeclamp...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0328578 |
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| Summary: | <h4>Background</h4>Hypertensive disorders of pregnancy affect about 10% of all pregnant women worldwide. A variety of hematological abnormalities may occur in women with pregnancy-induced hypertension. Thus, we aimed to compare coagulation profiles and platelet parameters among preeclampsia, eclampsia, and normotensive pregnant women in Northwest Ethiopia.<h4>Method</h4>A comparative cross-sectional study was conducted at University of Gondar and Felegehiwot Comprehensive Specialized Hospital, maternity wards from June 20 to November 15, 2024. A total of 180 participants were recruited using the convenience sampling technique. Socio-demographic and clinical data were collected using a structured questionnaire and participants' medical records. Eight milliliters of blood specimens were collected from each study participant. Coagulation profiles and platelet parameters were measured using a Genrui coagulation analyzer and an automated Mindray BC-5150 hematological analyzer, respectively. Data were entered into epi-data version 4.6.0.6 and exported to the SPSS version 26 software for analysis. Descriptive data were presented using tables and frequencies. One-way ANOVA and Kruskal-Wallis tests were used for normally distributed and skewed data, respectively. A p < 0.05 was considered statistically significant.<h4>Results</h4>A total of 180 pregnant women were enrolled/included in this study. The median PT and aPTT showed prolongation in preeclampsia and eclampsia patients, as compared to normotensive pregnant women, indicating a significant difference (p < 0.001) and (P = 0.002) respectively. The mean ± SD of mean platelet volume and PDW showed higher values in preeclampsia and eclampsia patients, as compared to normotensive pregnant women, demonstrating both a significant difference (P < 0.001). On the other hand, the mean platelet count in preeclampsia and eclampsia patients, were lower than in normotensive pregnant women, with a significant difference (p < 0.001).<h4>Conclusion and recommendations</h4>In this study, alteration of coagulation and platelet parameters were observed in preeclampsia and eclampsia pregnant womens compared to normotensive controls. Thus, a routine laboratory test of coagulation and platelet parameters for pregnant women with preeclampsia and eclampsia could be applicable to reduce the risk of coaglation and platelet abnormalities. |
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| ISSN: | 1932-6203 |