Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models

Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models

BackgroundOATD-01 is a chitinase-1 (CHIT1) inhibitor, reducing inflammation and fibrosis in animal models where chronic inflammation leads to tissue remodeling. CHIT1, predominantly secreted by macrophages, is overexpressed in metabolic dysfunction-associated steatohepatitis (MASH).Methods and resul...

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Main Authors: Katarzyna Drzewicka, Katarzyna M. Głuchowska, Michal Mlącki, Bartłomiej Hofman, Irina Tuszyńska, Tristram A. J. Ryan, Katarzyna Piwowar, Bartosz Wilczyński, Dorota Dymkowska, Marcin M. Grzybowski, Barbara Dymek, Tomasz Rejczak, Kamil Lisiecki, Adam Gołębiowski, Adam Jagielski, Angelika Muchowicz, Dylan Ryan, Krzysztof Zabłocki, Luke A. J. O’Neill, Zbigniew Zasłona
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
chitinase 1
OATD-01
MASH
fibrosis
inflammation
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544973/full
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