Effect of Immunoglobulin Therapy on the Rate of Infections in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation and or Treated with Immunomodulatory Agents
<p class="MsoNormal" style="margin: 0cm 0cm 0pt;"><span style="font-size: 11pt; color: windowtext; line-height: 200%; font-family: " lang="EN-US">There are few data available regarding the prevalence of infection in multiple myeloma...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2010-02-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/article/view/5590 |
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| author | Gerald Bates Burns Denise Amanda Cox Matthias Maiwald Alhossain A. Khalafallah Terry Hannan David Seaton Bernadene Fernandopulle Terry Brain |
| author_facet | Gerald Bates Burns Denise Amanda Cox Matthias Maiwald Alhossain A. Khalafallah Terry Hannan David Seaton Bernadene Fernandopulle Terry Brain |
| author_sort | Gerald Bates |
| collection | DOAJ |
| description | <p class="MsoNormal" style="margin: 0cm 0cm 0pt;"><span style="font-size: 11pt; color: windowtext; line-height: 200%; font-family: " lang="EN-US">There are few data available regarding the prevalence of infection in multiple myeloma (MM) patients in conjunction with newer generations of immunomodulatory drugs (thalidomide, bortezomib, lenalidomide) or post autologous stem cell transplantation.<span style="mso-spacerun: yes;"> </span>We retrospectively analyzed 47 patients with MM from March 2006 to June 2009 at our institution. All patients received thalidomide and steroid therapy for at least 6 months. Nine patients received bortezomib and 11 lenalidomide subsequently to thalidomide, because of disease progression and 22 patients underwent autologous stem cell transplantation.<strong style="mso-bidi-font-weight: normal;"><span style="mso-spacerun: yes;"> </span></strong><span style="mso-spacerun: yes;"> </span>The median age was 64 years (range 37-86), with a female–to-male ratio of 18:29. The median residual-serum IgG-level at time of infection was 3.2 g/L, IgA 0.3 g/L and IgM 0.2 g/L. Most patients suffered from recurrent moderate to severe infections. All patients except 3 received intravenous immunoglobulin (IVIG) therapy with a significant decline of the rate of infection thereafter. Our analysis shows that IVIG appears to be an effective strategy to prevent infection in MM patients. Further studies to confirm these findings are warranted. </span></p> |
| format | Article |
| id | doaj-art-51f243c075a24e39b587cee06d676c06 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2010-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-51f243c075a24e39b587cee06d676c062025-08-20T01:47:41ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062010-02-0121e2010005e2010005Effect of Immunoglobulin Therapy on the Rate of Infections in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation and or Treated with Immunomodulatory AgentsGerald BatesBurns DeniseAmanda CoxMatthias MaiwaldAlhossain A. KhalafallahTerry HannanDavid SeatonBernadene FernandopulleTerry Brain<p class="MsoNormal" style="margin: 0cm 0cm 0pt;"><span style="font-size: 11pt; color: windowtext; line-height: 200%; font-family: " lang="EN-US">There are few data available regarding the prevalence of infection in multiple myeloma (MM) patients in conjunction with newer generations of immunomodulatory drugs (thalidomide, bortezomib, lenalidomide) or post autologous stem cell transplantation.<span style="mso-spacerun: yes;"> </span>We retrospectively analyzed 47 patients with MM from March 2006 to June 2009 at our institution. All patients received thalidomide and steroid therapy for at least 6 months. Nine patients received bortezomib and 11 lenalidomide subsequently to thalidomide, because of disease progression and 22 patients underwent autologous stem cell transplantation.<strong style="mso-bidi-font-weight: normal;"><span style="mso-spacerun: yes;"> </span></strong><span style="mso-spacerun: yes;"> </span>The median age was 64 years (range 37-86), with a female–to-male ratio of 18:29. The median residual-serum IgG-level at time of infection was 3.2 g/L, IgA 0.3 g/L and IgM 0.2 g/L. Most patients suffered from recurrent moderate to severe infections. All patients except 3 received intravenous immunoglobulin (IVIG) therapy with a significant decline of the rate of infection thereafter. Our analysis shows that IVIG appears to be an effective strategy to prevent infection in MM patients. Further studies to confirm these findings are warranted. </span></p>http://www.mjhid.org/article/view/5590Multiple myeloma, autologous stem cell transplantation, immunomodulatory drugs, intravenous immunoglobulin, bacterial infection, viral infection. |
| spellingShingle | Gerald Bates Burns Denise Amanda Cox Matthias Maiwald Alhossain A. Khalafallah Terry Hannan David Seaton Bernadene Fernandopulle Terry Brain Effect of Immunoglobulin Therapy on the Rate of Infections in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation and or Treated with Immunomodulatory Agents Mediterranean Journal of Hematology and Infectious Diseases Multiple myeloma, autologous stem cell transplantation, immunomodulatory drugs, intravenous immunoglobulin, bacterial infection, viral infection. |
| title | Effect of Immunoglobulin Therapy on the Rate of Infections in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation and or Treated with Immunomodulatory Agents |
| title_full | Effect of Immunoglobulin Therapy on the Rate of Infections in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation and or Treated with Immunomodulatory Agents |
| title_fullStr | Effect of Immunoglobulin Therapy on the Rate of Infections in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation and or Treated with Immunomodulatory Agents |
| title_full_unstemmed | Effect of Immunoglobulin Therapy on the Rate of Infections in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation and or Treated with Immunomodulatory Agents |
| title_short | Effect of Immunoglobulin Therapy on the Rate of Infections in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation and or Treated with Immunomodulatory Agents |
| title_sort | effect of immunoglobulin therapy on the rate of infections in multiple myeloma patients undergoing autologous stem cell transplantation and or treated with immunomodulatory agents |
| topic | Multiple myeloma, autologous stem cell transplantation, immunomodulatory drugs, intravenous immunoglobulin, bacterial infection, viral infection. |
| url | http://www.mjhid.org/article/view/5590 |
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