Evaluation of renal and inflammatory markers in elderly diabetic patients in Port Harcourt
Background: Diabetes mellitus (DM) is a chronic metabolic disorder linked to hyperglycemia, systemic inflammation, and increased renal dysfunction risk, particularly in the elderly. The progression of DM complications in elderly individuals remains underexplored. Hence, this study aimed t...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia.edu Journals
2025-05-01
|
| Series: | Academia Medicine |
| Online Access: | https://www.academia.edu/129342033/Evaluation_of_renal_and_inflammatory_markers_in_elderly_diabetic_patients_in_Port_Harcourt |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849469744265035776 |
|---|---|
| author | Onengiyeofori Ibama Fred Kpane Uwikor |
| author_facet | Onengiyeofori Ibama Fred Kpane Uwikor |
| author_sort | Onengiyeofori Ibama |
| collection | DOAJ |
| description |
Background: Diabetes mellitus (DM) is a chronic metabolic disorder linked to hyperglycemia, systemic inflammation, and increased renal dysfunction risk, particularly in the elderly. The progression of DM complications in elderly individuals remains underexplored. Hence, this study aimed to evaluate renal function parameters and inflammatory markers in elderly individuals with DM in Port Harcourt, Nigeria. Methodology: We conducted a cross-sectional study including 298 participants (149 people with diabetes and 149 non-diabetic controls) aged 50–85 years. Blood samples were analyzed for fasting blood glucose (FBG), glycated hemoglobin (HbA1c), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), and serum creatinine. Urine samples were assessed for albumin and creatinine, and the albumin–creatinine ratio (ACR) was calculated. Data analysis was performed using SPSS, with significance at p < 0.05. Results: Diabetic participants had higher FBG (14.7 ± 1.2 vs. 4.8 ± 0.4 mmol/l, p < 0.001) and HbA1c (13.4 ± 2.9% vs. 4.9 ± 1.28%, p < 0.001). Inflammatory markers, including CRP (10.07 ± 3.65 vs. 6.36 ± 2.62 mg/l), ESR (59.72 ± 25.06 vs. 28.72 ± 19.22 mm/h), and IL-6 (238 ± 39 vs. 48 ± 9.1 pg/ml), were significantly elevated (p < 0.001). Renal parameters, including serum creatinine (132.0 ± 16.40 vs. 86.0 ± 9.02 mmol/l) and ACR (9.71 ± 3.95 vs. 3.93 ± 1.05), were higher in diabetics (p < 0.001). Females had higher CRP, ESR, IL-6, and urine albumin levels than males (p < 0.001). Conclusions: Elderly individuals in Port Harcourt with DM exhibit significant hyperglycemia, inflammation, and renal impairment, with females showing a greater inflammatory burden. These findings call for gender-sensitive strategies for DM management. |
| format | Article |
| id | doaj-art-51f0ca3c169f4cdab2a2b62e436eaf2b |
| institution | Kabale University |
| issn | 2994-435X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Academia.edu Journals |
| record_format | Article |
| series | Academia Medicine |
| spelling | doaj-art-51f0ca3c169f4cdab2a2b62e436eaf2b2025-08-20T03:25:22ZengAcademia.edu JournalsAcademia Medicine2994-435X2025-05-012210.20935/AcadMed7708Evaluation of renal and inflammatory markers in elderly diabetic patients in Port HarcourtOnengiyeofori Ibama0Fred Kpane Uwikor1Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Rivers State University, Nkpolu, P.M.B. 5080, Port-Harcourt, Nigeria.Department of Chemical Pathology, Faculty of Medical Laboratory Science, Federal University Otuoke, Bayelsa State PMB 126, Nigeria. Background: Diabetes mellitus (DM) is a chronic metabolic disorder linked to hyperglycemia, systemic inflammation, and increased renal dysfunction risk, particularly in the elderly. The progression of DM complications in elderly individuals remains underexplored. Hence, this study aimed to evaluate renal function parameters and inflammatory markers in elderly individuals with DM in Port Harcourt, Nigeria. Methodology: We conducted a cross-sectional study including 298 participants (149 people with diabetes and 149 non-diabetic controls) aged 50–85 years. Blood samples were analyzed for fasting blood glucose (FBG), glycated hemoglobin (HbA1c), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), and serum creatinine. Urine samples were assessed for albumin and creatinine, and the albumin–creatinine ratio (ACR) was calculated. Data analysis was performed using SPSS, with significance at p < 0.05. Results: Diabetic participants had higher FBG (14.7 ± 1.2 vs. 4.8 ± 0.4 mmol/l, p < 0.001) and HbA1c (13.4 ± 2.9% vs. 4.9 ± 1.28%, p < 0.001). Inflammatory markers, including CRP (10.07 ± 3.65 vs. 6.36 ± 2.62 mg/l), ESR (59.72 ± 25.06 vs. 28.72 ± 19.22 mm/h), and IL-6 (238 ± 39 vs. 48 ± 9.1 pg/ml), were significantly elevated (p < 0.001). Renal parameters, including serum creatinine (132.0 ± 16.40 vs. 86.0 ± 9.02 mmol/l) and ACR (9.71 ± 3.95 vs. 3.93 ± 1.05), were higher in diabetics (p < 0.001). Females had higher CRP, ESR, IL-6, and urine albumin levels than males (p < 0.001). Conclusions: Elderly individuals in Port Harcourt with DM exhibit significant hyperglycemia, inflammation, and renal impairment, with females showing a greater inflammatory burden. These findings call for gender-sensitive strategies for DM management.https://www.academia.edu/129342033/Evaluation_of_renal_and_inflammatory_markers_in_elderly_diabetic_patients_in_Port_Harcourt |
| spellingShingle | Onengiyeofori Ibama Fred Kpane Uwikor Evaluation of renal and inflammatory markers in elderly diabetic patients in Port Harcourt Academia Medicine |
| title | Evaluation of renal and inflammatory markers in elderly diabetic patients in Port Harcourt |
| title_full | Evaluation of renal and inflammatory markers in elderly diabetic patients in Port Harcourt |
| title_fullStr | Evaluation of renal and inflammatory markers in elderly diabetic patients in Port Harcourt |
| title_full_unstemmed | Evaluation of renal and inflammatory markers in elderly diabetic patients in Port Harcourt |
| title_short | Evaluation of renal and inflammatory markers in elderly diabetic patients in Port Harcourt |
| title_sort | evaluation of renal and inflammatory markers in elderly diabetic patients in port harcourt |
| url | https://www.academia.edu/129342033/Evaluation_of_renal_and_inflammatory_markers_in_elderly_diabetic_patients_in_Port_Harcourt |
| work_keys_str_mv | AT onengiyeoforiibama evaluationofrenalandinflammatorymarkersinelderlydiabeticpatientsinportharcourt AT fredkpaneuwikor evaluationofrenalandinflammatorymarkersinelderlydiabeticpatientsinportharcourt |