Prevalence of blood-borne virus infections and uptake of hepatitis C testing and treatment in Australian prisons: the AusHep studyResearch in context
Summary: Background: Incarcerated people are at high risk of blood-borne virus infections, particularly HCV, and a priority population for elimination efforts. This national bio-behavioural survey evaluated blood-borne virus prevalence and HCV testing-and-treatment uptake amongst people in Australi...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | The Lancet Regional Health. Western Pacific |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666606524002347 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846160319870664704 |
|---|---|
| author | Rugiatu Bah Yumi Sheehan Xiaoying Li Gregory J. Dore Jason Grebely Andrew R. Lloyd Behzad Hajarizadeh Andrew Lloyd Behzad Hajarizadeh Yumi Sheehan Rugi Bah Charlotte Li Marianne Byrne Tony Butler Bridget Musarurwa Elmira Hooshmand Annabeth Simpson Meya Alrayyani Jason Grebely Greg Dore Nikki Price Melissa Groom |
| author_facet | Rugiatu Bah Yumi Sheehan Xiaoying Li Gregory J. Dore Jason Grebely Andrew R. Lloyd Behzad Hajarizadeh Andrew Lloyd Behzad Hajarizadeh Yumi Sheehan Rugi Bah Charlotte Li Marianne Byrne Tony Butler Bridget Musarurwa Elmira Hooshmand Annabeth Simpson Meya Alrayyani Jason Grebely Greg Dore Nikki Price Melissa Groom |
| author_sort | Rugiatu Bah |
| collection | DOAJ |
| description | Summary: Background: Incarcerated people are at high risk of blood-borne virus infections, particularly HCV, and a priority population for elimination efforts. This national bio-behavioural survey evaluated blood-borne virus prevalence and HCV testing-and-treatment uptake amongst people in Australian prisons. Methods: Randomly-selected participants from 23 representative prisons nationally were offered point-of-care testing for HIV and HCV (anti-HCV) antibodies, hepatitis B surface antigen (HBsAg), and HCV RNA (if anti-HCV positive). Demographic data and previous HCV testing and treatment were collected by structured interview. Findings: 1599 individuals participated (98% participation; 89%male; median age 35 years; 49% ever injected drugs). Prevalence estimates were: 31.7% (95% CI:28.8–34.8) for anti-HCV; 8.0%for HCV RNA (95% CI:6.4–9.9); 0.5% (95% CI:0.2–1.1) for HBsAg, and 0.8% (95% CI: 0.4–1.7) for HIV antibody. Among participants who had ever injected drugs (n = 787), HCV RNA prevalence was highest among those injecting and sharing needles/syringes within the past month [27.9%; adjusted odds ratio (aOR):4.54 (95% CI:2.65–7.77). Among participants (n = 1599), 70.4% (95% CI: 67.4–73.2) had ever been tested for HCV (62.6% in prison). The highest likelihood of having had HCV testing was observed among participants who injected drugs in the past month (aOR = 10.37, 95% CI:5.72–0.18.78). Among those eligible (n = 318), 84.6% (95% CI:79.2–88.7) had ever received HCV treatment (75.0% in prison), and 67.8% (95% CI:61.7–73.4) were cured. The likelihood of HCV treatment was higher among those previously imprisoned, (aOR = 2.67, 95% CI:1.20–5.93). Interpretation: Despite high overall HCV testing and treatment uptake, the lower uptake and substantial ongoing HCV disease burden in some sub-populations highlights the need for continued prison-based elimination efforts with population-specific interventions. Funding: The AusHep study was funded by the Australian Government Department of Health and Aged Care. |
| format | Article |
| id | doaj-art-51ed2f0f44b5417ca08c943701550a00 |
| institution | Kabale University |
| issn | 2666-6065 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Western Pacific |
| spelling | doaj-art-51ed2f0f44b5417ca08c943701550a002024-11-22T07:39:10ZengElsevierThe Lancet Regional Health. Western Pacific2666-60652024-12-0153101240Prevalence of blood-borne virus infections and uptake of hepatitis C testing and treatment in Australian prisons: the AusHep studyResearch in contextRugiatu Bah0Yumi Sheehan1Xiaoying Li2Gregory J. Dore3Jason Grebely4Andrew R. Lloyd5Behzad Hajarizadeh6Andrew LloydBehzad HajarizadehYumi SheehanRugi BahCharlotte LiMarianne ByrneTony ButlerBridget MusarurwaElmira HooshmandAnnabeth SimpsonMeya AlrayyaniJason GrebelyGreg DoreNikki PriceMelissa GroomThe Kirby Institute, University of New South Wales (UNSW), Sydney, New South Wales, Australia; Corresponding author. The Kirby Institute - Level 5, UNSW, Wallace Wurth Building, NSW 2052, Australia.The Kirby Institute, University of New South Wales (UNSW), Sydney, New South Wales, AustraliaThe Kirby Institute, University of New South Wales (UNSW), Sydney, New South Wales, AustraliaThe Kirby Institute, University of New South Wales (UNSW), Sydney, New South Wales, AustraliaThe Kirby Institute, University of New South Wales (UNSW), Sydney, New South Wales, AustraliaThe Kirby Institute, University of New South Wales (UNSW), Sydney, New South Wales, AustraliaThe Kirby Institute, University of New South Wales (UNSW), Sydney, New South Wales, AustraliaSummary: Background: Incarcerated people are at high risk of blood-borne virus infections, particularly HCV, and a priority population for elimination efforts. This national bio-behavioural survey evaluated blood-borne virus prevalence and HCV testing-and-treatment uptake amongst people in Australian prisons. Methods: Randomly-selected participants from 23 representative prisons nationally were offered point-of-care testing for HIV and HCV (anti-HCV) antibodies, hepatitis B surface antigen (HBsAg), and HCV RNA (if anti-HCV positive). Demographic data and previous HCV testing and treatment were collected by structured interview. Findings: 1599 individuals participated (98% participation; 89%male; median age 35 years; 49% ever injected drugs). Prevalence estimates were: 31.7% (95% CI:28.8–34.8) for anti-HCV; 8.0%for HCV RNA (95% CI:6.4–9.9); 0.5% (95% CI:0.2–1.1) for HBsAg, and 0.8% (95% CI: 0.4–1.7) for HIV antibody. Among participants who had ever injected drugs (n = 787), HCV RNA prevalence was highest among those injecting and sharing needles/syringes within the past month [27.9%; adjusted odds ratio (aOR):4.54 (95% CI:2.65–7.77). Among participants (n = 1599), 70.4% (95% CI: 67.4–73.2) had ever been tested for HCV (62.6% in prison). The highest likelihood of having had HCV testing was observed among participants who injected drugs in the past month (aOR = 10.37, 95% CI:5.72–0.18.78). Among those eligible (n = 318), 84.6% (95% CI:79.2–88.7) had ever received HCV treatment (75.0% in prison), and 67.8% (95% CI:61.7–73.4) were cured. The likelihood of HCV treatment was higher among those previously imprisoned, (aOR = 2.67, 95% CI:1.20–5.93). Interpretation: Despite high overall HCV testing and treatment uptake, the lower uptake and substantial ongoing HCV disease burden in some sub-populations highlights the need for continued prison-based elimination efforts with population-specific interventions. Funding: The AusHep study was funded by the Australian Government Department of Health and Aged Care.http://www.sciencedirect.com/science/article/pii/S2666606524002347HCVHBVHIVJailPrisonEpidemiology |
| spellingShingle | Rugiatu Bah Yumi Sheehan Xiaoying Li Gregory J. Dore Jason Grebely Andrew R. Lloyd Behzad Hajarizadeh Andrew Lloyd Behzad Hajarizadeh Yumi Sheehan Rugi Bah Charlotte Li Marianne Byrne Tony Butler Bridget Musarurwa Elmira Hooshmand Annabeth Simpson Meya Alrayyani Jason Grebely Greg Dore Nikki Price Melissa Groom Prevalence of blood-borne virus infections and uptake of hepatitis C testing and treatment in Australian prisons: the AusHep studyResearch in context The Lancet Regional Health. Western Pacific HCV HBV HIV Jail Prison Epidemiology |
| title | Prevalence of blood-borne virus infections and uptake of hepatitis C testing and treatment in Australian prisons: the AusHep studyResearch in context |
| title_full | Prevalence of blood-borne virus infections and uptake of hepatitis C testing and treatment in Australian prisons: the AusHep studyResearch in context |
| title_fullStr | Prevalence of blood-borne virus infections and uptake of hepatitis C testing and treatment in Australian prisons: the AusHep studyResearch in context |
| title_full_unstemmed | Prevalence of blood-borne virus infections and uptake of hepatitis C testing and treatment in Australian prisons: the AusHep studyResearch in context |
| title_short | Prevalence of blood-borne virus infections and uptake of hepatitis C testing and treatment in Australian prisons: the AusHep studyResearch in context |
| title_sort | prevalence of blood borne virus infections and uptake of hepatitis c testing and treatment in australian prisons the aushep studyresearch in context |
| topic | HCV HBV HIV Jail Prison Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2666606524002347 |
| work_keys_str_mv | AT rugiatubah prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT yumisheehan prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT xiaoyingli prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT gregoryjdore prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT jasongrebely prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT andrewrlloyd prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT behzadhajarizadeh prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT andrewlloyd prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT behzadhajarizadeh prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT yumisheehan prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT rugibah prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT charlotteli prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT mariannebyrne prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT tonybutler prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT bridgetmusarurwa prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT elmirahooshmand prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT annabethsimpson prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT meyaalrayyani prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT jasongrebely prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT gregdore prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT nikkiprice prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext AT melissagroom prevalenceofbloodbornevirusinfectionsanduptakeofhepatitisctestingandtreatmentinaustralianprisonstheaushepstudyresearchincontext |