A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome.

A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome.

<h4>Aims</h4>With ageing extracellular material is deposited in Bruch's membrane, as drusen. Lipofuscin is deposited in retinal pigment epithelial cells. Both of these changes are associated with age related macular degeneration, a disease now believed to involve chronic inflammatio...

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Bibliographic Details
Main Authors: Owen A Anderson, Arthur Finkelstein, David T Shima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0067263&type=printable
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