Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells

Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells

Arginase-1 (Arg1) is expressed by regulatory myeloid cells in the tumor microenvironment (TME), where they play a pro-tumorigenic and T-cell suppressive role. Arg1-specific CD4+ and CD8+ memory T cells have been observed in both healthy individuals and cancer patients. However, while the function of...

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Bibliographic Details
Main Authors: Hannah Jorinde Glöckner, Evelina Martinenaite, Thomas Landkildehus Lisle, Jacob Grauslund, Shamaila Ahmad, Özcan Met, Per Thor Straten, Mads Hald Andersen
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Arginase-1
anti-regulatory T cells
immune modulatory vaccines
myeloid cells
tumor microenvironment
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2318053
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