Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer
Gastric cancer is one of the most common and aggressive malignancies. Both bacterial virulence factors and host chronic inflammation are thought to promote gastric cancer development. In this study, we investigated the potential involvement of follicular helper T cells in gastric cancer. Functions o...
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SAGE Publishing
2017-05-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317705747 |
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| author | Hong Zhang Rongxi Yue Pengfei Zhao Xuetao Yu Junguo Li Guoqing Ma Jiahong Tang Lixin Zhang Liying Feng Lidong Sun Zongchang Song Chunliang Guo Ning Wang |
| author_facet | Hong Zhang Rongxi Yue Pengfei Zhao Xuetao Yu Junguo Li Guoqing Ma Jiahong Tang Lixin Zhang Liying Feng Lidong Sun Zongchang Song Chunliang Guo Ning Wang |
| author_sort | Hong Zhang |
| collection | DOAJ |
| description | Gastric cancer is one of the most common and aggressive malignancies. Both bacterial virulence factors and host chronic inflammation are thought to promote gastric cancer development. In this study, we investigated the potential involvement of follicular helper T cells in gastric cancer. Functions of follicular helper T subsets were examined in Helicobacter pylori –infected gastric cancer patients and H. pylori –infected but asymptomatic individuals. We found that the follicular helper T cells in gastric cancer individuals were skewed toward the Th1 and Th17 subsets compared to those in H. pylori –infected but asymptomatic individuals. In a naive B cell–follicular helper T cell coculture, the Th1–follicular helper T cells by themselves were ineffective at stimulating a robust antibody response, unlike the Th2–follicular helper T and Th17–follicular helper T cells. However, Th1–follicular helper T cells significantly promoted the immunoglobulin G response in collaboration with other follicular helper T subsets, through the secretion of interferon gamma. We also found that Th1–follicular helper T cells suppressed the development of interleukin-10 + regulatory B cells, a cell type previously thought to protect H. pylori –infected individuals from tissue damage. In addition, the frequency of Th1–follicular helper T cells in gastric cancer patients was negatively correlated with the disease-free survival of gastric cancer patients after tumor resection. These results suggested that dysregulation of follicular helper T subsets in gastric cancer patients, characterized by increased Th1–follicular helper T cells, contributed to inflammation and tumor development. |
| format | Article |
| id | doaj-art-51ea3078902a4b4b8a363efa88772c5d |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-51ea3078902a4b4b8a363efa88772c5d2025-08-20T02:55:01ZengSAGE PublishingTumor Biology1423-03802017-05-013910.1177/1010428317705747Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancerHong Zhang0Rongxi Yue1Pengfei Zhao2Xuetao Yu3Junguo Li4Guoqing Ma5Jiahong Tang6Lixin Zhang7Liying Feng8Lidong Sun9Zongchang Song10Chunliang Guo11Ning Wang12Department of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, ChinaDepartment of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, ChinaDepartment of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, ChinaDepartment of Oncology, Tianyou Hospital, Tongji University, Shanghai, ChinaReproductive Medicine Center, PLA Army General Hospital, Beijing, ChinaDepartment of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, ChinaDepartment of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, ChinaDepartment of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, ChinaDepartment of Ultrasound, PLA Army General Hospital, Beijing, ChinaDepartment of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, ChinaDepartment of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, ChinaDepartment of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, ChinaDepartment of Obstetrics & Gynecology, The 155th Central Hospital of PLA, Kaifeng, ChinaGastric cancer is one of the most common and aggressive malignancies. Both bacterial virulence factors and host chronic inflammation are thought to promote gastric cancer development. In this study, we investigated the potential involvement of follicular helper T cells in gastric cancer. Functions of follicular helper T subsets were examined in Helicobacter pylori –infected gastric cancer patients and H. pylori –infected but asymptomatic individuals. We found that the follicular helper T cells in gastric cancer individuals were skewed toward the Th1 and Th17 subsets compared to those in H. pylori –infected but asymptomatic individuals. In a naive B cell–follicular helper T cell coculture, the Th1–follicular helper T cells by themselves were ineffective at stimulating a robust antibody response, unlike the Th2–follicular helper T and Th17–follicular helper T cells. However, Th1–follicular helper T cells significantly promoted the immunoglobulin G response in collaboration with other follicular helper T subsets, through the secretion of interferon gamma. We also found that Th1–follicular helper T cells suppressed the development of interleukin-10 + regulatory B cells, a cell type previously thought to protect H. pylori –infected individuals from tissue damage. In addition, the frequency of Th1–follicular helper T cells in gastric cancer patients was negatively correlated with the disease-free survival of gastric cancer patients after tumor resection. These results suggested that dysregulation of follicular helper T subsets in gastric cancer patients, characterized by increased Th1–follicular helper T cells, contributed to inflammation and tumor development.https://doi.org/10.1177/1010428317705747 |
| spellingShingle | Hong Zhang Rongxi Yue Pengfei Zhao Xuetao Yu Junguo Li Guoqing Ma Jiahong Tang Lixin Zhang Liying Feng Lidong Sun Zongchang Song Chunliang Guo Ning Wang Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer Tumor Biology |
| title | Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer |
| title_full | Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer |
| title_fullStr | Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer |
| title_full_unstemmed | Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer |
| title_short | Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer |
| title_sort | proinflammatory follicular helper t cells promote immunoglobulin g secretion suppress regulatory b cell development and correlate with worse clinical outcomes in gastric cancer |
| url | https://doi.org/10.1177/1010428317705747 |
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