EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway

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Main Authors: Keying Li, Changlong Xu, Lulu Liu, Yunjuan Wang, Jun Chen, Chunyuan Li, Zitong Peng, Xiaoqian Li, Gang Chang, Zili Lei, Yanhong Yang
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Medicine
Online Access:https://doi.org/10.1002/ctm2.70219
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author Keying Li
Changlong Xu
Lulu Liu
Yunjuan Wang
Jun Chen
Chunyuan Li
Zitong Peng
Xiaoqian Li
Gang Chang
Zili Lei
Yanhong Yang
author_facet Keying Li
Changlong Xu
Lulu Liu
Yunjuan Wang
Jun Chen
Chunyuan Li
Zitong Peng
Xiaoqian Li
Gang Chang
Zili Lei
Yanhong Yang
author_sort Keying Li
collection DOAJ
format Article
id doaj-art-51e94e891d1f4d838a9f81047a35de99
institution OA Journals
issn 2001-1326
language English
publishDate 2025-02-01
publisher Wiley
record_format Article
series Clinical and Translational Medicine
spelling doaj-art-51e94e891d1f4d838a9f81047a35de992025-08-20T02:09:37ZengWileyClinical and Translational Medicine2001-13262025-02-01152n/an/a10.1002/ctm2.70219EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathwayKeying Li0Changlong Xu1Lulu Liu2Yunjuan Wang3Jun Chen4Chunyuan Li5Zitong Peng6Xiaoqian Li7Gang Chang8Zili Lei9Yanhong Yang10Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University Guangzhou P.R. ChinaThe Reproductive Medical Center of Nanning Second People's Hospital Nanning P.R. ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University Guangzhou P.R. ChinaThe First Affiliated Hospital (School of Clinical Medicine) Guangdong Pharmaceutical University Guangzhou P.R. ChinaDepartment of Biochemistry and Molecular Biology Shenzhen University Medical School Shenzhen P.R. ChinaThe Reproductive Medical Center of Nanning Second People's Hospital Nanning P.R. ChinaThe First Affiliated Hospital (School of Clinical Medicine) Guangdong Pharmaceutical University Guangzhou P.R. ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University Guangzhou P.R. ChinaDepartment of Biochemistry and Molecular Biology Shenzhen University Medical School Shenzhen P.R. ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University Guangzhou P.R. ChinaThe First Affiliated Hospital (School of Clinical Medicine) Guangdong Pharmaceutical University Guangzhou P.R. Chinahttps://doi.org/10.1002/ctm2.70219
spellingShingle Keying Li
Changlong Xu
Lulu Liu
Yunjuan Wang
Jun Chen
Chunyuan Li
Zitong Peng
Xiaoqian Li
Gang Chang
Zili Lei
Yanhong Yang
EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway
Clinical and Translational Medicine
title EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway
title_full EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway
title_fullStr EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway
title_full_unstemmed EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway
title_short EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway
title_sort epcam deficiency causes the premature ageing of intestinal stem cells via egfr sp1 mtorc1 pathway
url https://doi.org/10.1002/ctm2.70219
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