A glyoxal-specific aldehyde signaling axis in Pseudomonas aeruginosa that influences quorum sensing and infection

A glyoxal-specific aldehyde signaling axis in Pseudomonas aeruginosa that influences quorum sensing and infection

Abstract The universally conserved α-oxoaldehydes glyoxal (GO) and methylglyoxal (MGO) are toxic metabolic byproducts whose accumulation can lead to cell death. In the absence of a known, natural inducer of the GO-specific response in prokaryotes, we exploited RNA-seq to define a GO response in the...

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Main Authors: Christopher J. Corcoran, Bonnie J. Cuthbert, David G. Glanville, Mailyn Terrado, Diana Valverde Mendez, Benjamin P. Bratton, Daniel E. Schemenauer, Valerie L. Tokars, Thomas G. Martin, Lawrence W. Rasmussen, Matthew C. Madison, Andrew F. Maule, Joshua W. Shaevitz, Boo Shan Tseng, Julian P. Whitelegge, Catherine Putonti, Amit Gaggar, Jordan R. Beach, Jonathan A. Kirk, Alfonso Mondragón, Abby R. Kroken, Jonathan P. Allen, Celia W. Goulding, Andrew T. Ulijasz
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61469-8
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