Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis
Abstract The role of pre-treatment HBV DNA levels on the prognosis of hepatitis B virus-related decompensated cirrhosis is unclear. This study investigated the effects of pre-treatment HBV DNA and other determinants on short-term and long-term survival of chronic hepatitis B (CHB) patients with deco...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84413-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559566785970176 |
|---|---|
| author | Yi-Jie Huang Jun-Sing Wang Cheng-Hsu Chen Shou-Wu Lee Chung-Hsin Chang Szu-Chia Liao Yen-Chun Peng Teng-Yu Lee Tsai-Chung Li |
| author_facet | Yi-Jie Huang Jun-Sing Wang Cheng-Hsu Chen Shou-Wu Lee Chung-Hsin Chang Szu-Chia Liao Yen-Chun Peng Teng-Yu Lee Tsai-Chung Li |
| author_sort | Yi-Jie Huang |
| collection | DOAJ |
| description | Abstract The role of pre-treatment HBV DNA levels on the prognosis of hepatitis B virus-related decompensated cirrhosis is unclear. This study investigated the effects of pre-treatment HBV DNA and other determinants on short-term and long-term survival of chronic hepatitis B (CHB) patients with decompensated cirrhosis. A total of 278 cirrhotic decompensated CHB patients treated with entecavir or tenofovir disoproxil fumarate were retrospectively enrolled. Cox regression models were used to analyze factors associated with all-cause mortality. The median follow-up time was 17 months (IQR2.17–58.94), during which 132 patients (47.4%) either died or underwent liver transplantation. The cumulative incidence of all-cause mortality was 16%, 29%, 34%, 39%, and 51% at the 1-month, 3-month, 6-month, 1-year, and 5-year follow-ups, respectively. Risk factors associated with 3-month all-cause mortality were age, presence of ascites and hepatic encephalopathy, baseline hepatitis flares, pre-treatment HBV DNA levels, and MELD scores. In the subgroup analysis, for 3-month all-cause mortality, significant associations of age, baseline hepatitis flares, and MELD scores with pre-treatment HBV DNA levels were observed (p for interaction were 0.005, 0.032, and 0.030, respectively). Risk factors associated with 5-year all-cause mortality were age, the presence of ascites and hepatic encephalopathy, and MELD scores. Liver functional reserve and age played a critical role in the prognosis of CHB patients with decompensated cirrhosis. Pre-treatment HBV DNA levels had an impact on short-term all-cause mortality, but not on long-term all-cause mortality. |
| format | Article |
| id | doaj-art-51e390e716f9404dbc8eb48e413561fb |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-51e390e716f9404dbc8eb48e413561fb2025-01-05T12:23:20ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-024-84413-0Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosisYi-Jie Huang0Jun-Sing Wang1Cheng-Hsu Chen2Shou-Wu Lee3Chung-Hsin Chang4Szu-Chia Liao5Yen-Chun Peng6Teng-Yu Lee7Tsai-Chung Li8Department of Public Health, College of Public Health, China Medical UniversityDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing UniversityDivision of Nephrology, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General HospitalDepartment of Public Health, College of Public Health, China Medical UniversityAbstract The role of pre-treatment HBV DNA levels on the prognosis of hepatitis B virus-related decompensated cirrhosis is unclear. This study investigated the effects of pre-treatment HBV DNA and other determinants on short-term and long-term survival of chronic hepatitis B (CHB) patients with decompensated cirrhosis. A total of 278 cirrhotic decompensated CHB patients treated with entecavir or tenofovir disoproxil fumarate were retrospectively enrolled. Cox regression models were used to analyze factors associated with all-cause mortality. The median follow-up time was 17 months (IQR2.17–58.94), during which 132 patients (47.4%) either died or underwent liver transplantation. The cumulative incidence of all-cause mortality was 16%, 29%, 34%, 39%, and 51% at the 1-month, 3-month, 6-month, 1-year, and 5-year follow-ups, respectively. Risk factors associated with 3-month all-cause mortality were age, presence of ascites and hepatic encephalopathy, baseline hepatitis flares, pre-treatment HBV DNA levels, and MELD scores. In the subgroup analysis, for 3-month all-cause mortality, significant associations of age, baseline hepatitis flares, and MELD scores with pre-treatment HBV DNA levels were observed (p for interaction were 0.005, 0.032, and 0.030, respectively). Risk factors associated with 5-year all-cause mortality were age, the presence of ascites and hepatic encephalopathy, and MELD scores. Liver functional reserve and age played a critical role in the prognosis of CHB patients with decompensated cirrhosis. Pre-treatment HBV DNA levels had an impact on short-term all-cause mortality, but not on long-term all-cause mortality.https://doi.org/10.1038/s41598-024-84413-0Chronic hepatitis BDecompensated cirrhosisHBV DNA |
| spellingShingle | Yi-Jie Huang Jun-Sing Wang Cheng-Hsu Chen Shou-Wu Lee Chung-Hsin Chang Szu-Chia Liao Yen-Chun Peng Teng-Yu Lee Tsai-Chung Li Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis Scientific Reports Chronic hepatitis B Decompensated cirrhosis HBV DNA |
| title | Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis |
| title_full | Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis |
| title_fullStr | Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis |
| title_full_unstemmed | Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis |
| title_short | Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis |
| title_sort | determinants of outcomes in patients with hepatitis b virus decompensated cirrhosis |
| topic | Chronic hepatitis B Decompensated cirrhosis HBV DNA |
| url | https://doi.org/10.1038/s41598-024-84413-0 |
| work_keys_str_mv | AT yijiehuang determinantsofoutcomesinpatientswithhepatitisbvirusdecompensatedcirrhosis AT junsingwang determinantsofoutcomesinpatientswithhepatitisbvirusdecompensatedcirrhosis AT chenghsuchen determinantsofoutcomesinpatientswithhepatitisbvirusdecompensatedcirrhosis AT shouwulee determinantsofoutcomesinpatientswithhepatitisbvirusdecompensatedcirrhosis AT chunghsinchang determinantsofoutcomesinpatientswithhepatitisbvirusdecompensatedcirrhosis AT szuchialiao determinantsofoutcomesinpatientswithhepatitisbvirusdecompensatedcirrhosis AT yenchunpeng determinantsofoutcomesinpatientswithhepatitisbvirusdecompensatedcirrhosis AT tengyulee determinantsofoutcomesinpatientswithhepatitisbvirusdecompensatedcirrhosis AT tsaichungli determinantsofoutcomesinpatientswithhepatitisbvirusdecompensatedcirrhosis |