False-negative bone scan and choline PET/CT study in a case of prostate cancer: The pitfall of the small cell prostate carcinoma variant
We present a rare variant of prostate carcinoma. The patient is a 45-year-old male with elevated prostate-specific antigen levels at screening. Magnetic resonance imaging revealed hyperenhancing lesions throughout the axial skeleton. The fluorine-18 fluorocholine (FCH) positron emission tomography/c...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2012-04-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.103422 |
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| _version_ | 1850045331187695616 |
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| author | Ammad Al-Tamimi Andrew Tan Sidney Kwong Christopher Sam Angela Chong Cher Tan |
| author_facet | Ammad Al-Tamimi Andrew Tan Sidney Kwong Christopher Sam Angela Chong Cher Tan |
| author_sort | Ammad Al-Tamimi |
| collection | DOAJ |
| description | We present a rare variant of prostate carcinoma. The patient is a 45-year-old male with elevated prostate-specific antigen levels at screening. Magnetic resonance imaging revealed hyperenhancing lesions throughout the axial skeleton. The fluorine-18 fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) scan showed no abnormal bone findings. Subsequently, a technetium-99 methydiphosphonate (Tc99m-MDP) bone scan was performed, with additional correlative single-photon emission computed tomography (SPECT)/CT imaging of the pelvis and the results were essentially normal. A percutaneous core biopsy of one of the bone lesions in L5 was performed and histology confirmed small cell (neuroendocrine) variant of prostate cancer. Our case illustrates a possible pitfall in molecular imaging of prostate carcinomas, whereby both bone scintigraphy and FCH PET/CT scans showed no definite bone lesions to correlate with marrow signal abnormalities seen on MR imaging. This highlights the need for caution in the diagnostic evaluation of prostate cancers with known small cell variants. |
| format | Article |
| id | doaj-art-51dc68ccad6643a7bbce96e2b0d29690 |
| institution | DOAJ |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2012-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-51dc68ccad6643a7bbce96e2b0d296902025-08-20T02:54:43ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122012-04-011102757810.4103/1450-1147.103422False-negative bone scan and choline PET/CT study in a case of prostate cancer: The pitfall of the small cell prostate carcinoma variantAmmad Al-Tamimi0Andrew Tan1Sidney Kwong2Christopher Sam3Angela Chong4Cher Tan5Department of Nuclear Medicine and PET, Singapore General Hospital, SingaporeDepartment of Nuclear Medicine and PET, Singapore General Hospital, SingaporeDepartment of Nuclear Medicine and PET, Singapore General Hospital, SingaporeDepartment of Urology, Singapore General Hospital, SingaporeDepartment of Pathology, Singapore General Hospital, SingaporeDepartment of Diagnostic Radiology, Tan Tock Seng General Hospital, SingaporeWe present a rare variant of prostate carcinoma. The patient is a 45-year-old male with elevated prostate-specific antigen levels at screening. Magnetic resonance imaging revealed hyperenhancing lesions throughout the axial skeleton. The fluorine-18 fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) scan showed no abnormal bone findings. Subsequently, a technetium-99 methydiphosphonate (Tc99m-MDP) bone scan was performed, with additional correlative single-photon emission computed tomography (SPECT)/CT imaging of the pelvis and the results were essentially normal. A percutaneous core biopsy of one of the bone lesions in L5 was performed and histology confirmed small cell (neuroendocrine) variant of prostate cancer. Our case illustrates a possible pitfall in molecular imaging of prostate carcinomas, whereby both bone scintigraphy and FCH PET/CT scans showed no definite bone lesions to correlate with marrow signal abnormalities seen on MR imaging. This highlights the need for caution in the diagnostic evaluation of prostate cancers with known small cell variants.http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.103422fluorocholinepositron emission tomographyprostate carcinomasmall cell cancer |
| spellingShingle | Ammad Al-Tamimi Andrew Tan Sidney Kwong Christopher Sam Angela Chong Cher Tan False-negative bone scan and choline PET/CT study in a case of prostate cancer: The pitfall of the small cell prostate carcinoma variant World Journal of Nuclear Medicine fluorocholine positron emission tomography prostate carcinoma small cell cancer |
| title | False-negative bone scan and choline PET/CT study in a case of prostate cancer: The pitfall of the small cell prostate carcinoma variant |
| title_full | False-negative bone scan and choline PET/CT study in a case of prostate cancer: The pitfall of the small cell prostate carcinoma variant |
| title_fullStr | False-negative bone scan and choline PET/CT study in a case of prostate cancer: The pitfall of the small cell prostate carcinoma variant |
| title_full_unstemmed | False-negative bone scan and choline PET/CT study in a case of prostate cancer: The pitfall of the small cell prostate carcinoma variant |
| title_short | False-negative bone scan and choline PET/CT study in a case of prostate cancer: The pitfall of the small cell prostate carcinoma variant |
| title_sort | false negative bone scan and choline pet ct study in a case of prostate cancer the pitfall of the small cell prostate carcinoma variant |
| topic | fluorocholine positron emission tomography prostate carcinoma small cell cancer |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.103422 |
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