Paediatric Multidrug-Resistant Tuberculosis with HIV Coinfection: A Case Report
Background. Tuberculosis is a major public health problem, and its control has been facing a lot of challenges with emergence of HIV. The occurrence of multidrug-resistant strain has also propounded the problem especially in children where diagnosis is difficult to make. Multidrug-resistant tubercul...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/756152 |
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| author | Huldah I. Nwokeukwu Paulinus N. Okafor Onuka Okorie Ihuoma K. Ukpabi |
| author_facet | Huldah I. Nwokeukwu Paulinus N. Okafor Onuka Okorie Ihuoma K. Ukpabi |
| author_sort | Huldah I. Nwokeukwu |
| collection | DOAJ |
| description | Background. Tuberculosis is a major public health problem, and its control has been facing a lot of challenges with emergence of HIV. The occurrence of multidrug-resistant strain has also propounded the problem especially in children where diagnosis is difficult to make. Multidrug-resistant tuberculosis (MDR-TB) is in vitro resistant to isoniazid (H) and rifampicin (R). Paediatric multi-drug resistant tuberculosis with HIV coinfection is rare, and there is no documented report from Nigeria. Objective. To report a case of paediatric MDR-TB in Nigeria about it. Methods. The case note of the patient was retrieved, and relevant data were extracted and summarized. Results. A 9-year-old female HIV-positive pupil with a year history of recurrent cough, 3 months history of recurrent fever, and generalized weight loss was diagnosed and treated for tuberculosis but failed after retreatment. She was later diagnosed with MDR-TB and is presently on DOT-Plus regimen. Conclusion. Paediatric MDR-TB with HIV co-infection is rare. Early diagnosis and treatment is important to prevent spread of the disease. The use of Isoniazid preventive therapy is recommended for children who come in contact with patients with active tuberculosis and also for HIV patients without active tuberculosis. |
| format | Article |
| id | doaj-art-51db8ffaf72f4239a9726760ec3577cd |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-51db8ffaf72f4239a9726760ec3577cd2025-08-20T02:05:41ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/756152756152Paediatric Multidrug-Resistant Tuberculosis with HIV Coinfection: A Case ReportHuldah I. Nwokeukwu0Paulinus N. Okafor1Onuka Okorie2Ihuoma K. Ukpabi3Department of Community Medicine, Federal Medical Centre, PMB 7001, Umuahia, Abia State, NigeriaDepartment of Community Medicine, Federal Medical Centre, PMB 7001, Umuahia, Abia State, NigeriaDepartment of Public Health, Ministry of Health, Abia State, NigeriaDepartment of Paediatrics, Federal Medical Centre, PMB 7001, Umuahia, Abia State, NigeriaBackground. Tuberculosis is a major public health problem, and its control has been facing a lot of challenges with emergence of HIV. The occurrence of multidrug-resistant strain has also propounded the problem especially in children where diagnosis is difficult to make. Multidrug-resistant tuberculosis (MDR-TB) is in vitro resistant to isoniazid (H) and rifampicin (R). Paediatric multi-drug resistant tuberculosis with HIV coinfection is rare, and there is no documented report from Nigeria. Objective. To report a case of paediatric MDR-TB in Nigeria about it. Methods. The case note of the patient was retrieved, and relevant data were extracted and summarized. Results. A 9-year-old female HIV-positive pupil with a year history of recurrent cough, 3 months history of recurrent fever, and generalized weight loss was diagnosed and treated for tuberculosis but failed after retreatment. She was later diagnosed with MDR-TB and is presently on DOT-Plus regimen. Conclusion. Paediatric MDR-TB with HIV co-infection is rare. Early diagnosis and treatment is important to prevent spread of the disease. The use of Isoniazid preventive therapy is recommended for children who come in contact with patients with active tuberculosis and also for HIV patients without active tuberculosis.http://dx.doi.org/10.1155/2013/756152 |
| spellingShingle | Huldah I. Nwokeukwu Paulinus N. Okafor Onuka Okorie Ihuoma K. Ukpabi Paediatric Multidrug-Resistant Tuberculosis with HIV Coinfection: A Case Report Case Reports in Medicine |
| title | Paediatric Multidrug-Resistant Tuberculosis with HIV
Coinfection: A Case Report |
| title_full | Paediatric Multidrug-Resistant Tuberculosis with HIV
Coinfection: A Case Report |
| title_fullStr | Paediatric Multidrug-Resistant Tuberculosis with HIV
Coinfection: A Case Report |
| title_full_unstemmed | Paediatric Multidrug-Resistant Tuberculosis with HIV
Coinfection: A Case Report |
| title_short | Paediatric Multidrug-Resistant Tuberculosis with HIV
Coinfection: A Case Report |
| title_sort | paediatric multidrug resistant tuberculosis with hiv coinfection a case report |
| url | http://dx.doi.org/10.1155/2013/756152 |
| work_keys_str_mv | AT huldahinwokeukwu paediatricmultidrugresistanttuberculosiswithhivcoinfectionacasereport AT paulinusnokafor paediatricmultidrugresistanttuberculosiswithhivcoinfectionacasereport AT onukaokorie paediatricmultidrugresistanttuberculosiswithhivcoinfectionacasereport AT ihuomakukpabi paediatricmultidrugresistanttuberculosiswithhivcoinfectionacasereport |